Skip to main content
SpringerLink
Log in
Book cover

Genetic Basis of Oral Health Conditions pp 23–31Cite as

Genetic Basis of Tooth Agenesis, Supernumerary Teeth, and Other Dental Abnormalities

  • Chapter
  • First Online:

Abstract

Tooth agenesis is the most common congenital abnormality in humans. The identification of gene mutations in severe forms of tooth agenesis (oligodontia) provided a tool for the acceleration of the understanding of dental development. An association between oligodontia and cancer has added to the relevance of studying these conditions. Most cases of tooth agenesis, as well as other dental abnormalities, fit a multifactorial or complex mode of inheritance. Genetic studies of supernumerary teeth and other dental abnormalities are emerging, but the lack of comprehensive annotations of these phenotypes is likely to preclude the ability to study these abnormalities in populations with large-scale genotyping data.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Ahlqwist M, Gröndahl HG. Prevalence of impacted teeth and associated pathology in middle-aged and older Swedish women. Community Dent Oral Epidemiol. 1991;19(2):116–9.

    Article  CAS  Google Scholar 

  • Alam MK, Hamza MA, Khafiz MA, Rahman SA, Shaari R, Hassan A. Multivariate analysis of factors affecting presence and/or agenesis of third molar tooth. PLoS One. 2014;9(6):e101157.

    Article  Google Scholar 

  • American Public Health Association. Opposition to prophylactic removal of third molars (wisdom teeth). Policy Statement Database Policy Number 20085; 2008.

    Google Scholar 

  • Antanas S, Giedrè T. Effect of the lower third molars on the lower dental arch crowding. Stomatologija. 2006;8(3):80–4.

    Google Scholar 

  • Arikan V, Cumaogullari O, Ozgul BM, Oz FT. Investigation of SOSTDC1 gene in non-syndromic patients with supernumerary teeth. Med Oral Patol Oral Cir Bucal. 2018;23(5):e531–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bae DH, Lee JH, Song JS, Jung HS, Choi HJ, Kim JH. Genetic analysis of non-syndromic familial multiple supernumerary premolars. Acta Odontol Scand. 2017;75(5):350–4.

    Article  CAS  Google Scholar 

  • Callahan N, Modesto A, Deeley K, Meira R, Vieira AR. Transforming growth factor alpha (TGFA), human tooth agenesis, and evidence of segmental uniparental isodisomy. Eur J Oral Sci. 2009;117:20–6.

    Article  CAS  Google Scholar 

  • Celikoglu M, Kamak H. Patterns of third-molar agenesis in an orthodontic patient population with different skeletal malocclusions. Angle Orthod. 2012;82(1):165–9.

    Article  Google Scholar 

  • Celikoglu M, Bayram M, Nur M. Patterns of third-molar agenesis and associated dental anomalies in an orthodontic population. Am J Orthod Dentofac Orthop. 2011;140(6):856–60.

    Article  Google Scholar 

  • Chung CJ, Han J-H, Kim K-H. The pattern and prevalence of hypodontia in Koreans. Oral Dis. 2008;14(7):620–5.

    Article  CAS  Google Scholar 

  • Dinckan N, Du R, Akdemir ZC, Bayram Y, Jhangiani SN, Doddapaneni H, Hu J, Muzny DM, Guven Y, Aktoren O, Kayserili H, Boerwinkle E, Gibbs RA, Posey JE, Lupski JR, Uyguner ZO, Letra A. A biallelic ANTXR1 variant expands the anthrax toxin receptor associated phenotype to tooth agenesis. Am J Med Genet A. 2018a;176(4):1015–22.

    Article  CAS  Google Scholar 

  • Dinckan N, Du R, Petty LE, Coban-Akdemir Z, Jhangiani SN, Paine I, Baugh EH, Erdem AP, Kayserili H, Doddapaneni H, Hu J, Muzny DM, Boerwinkle E, Gibbs RA, Lupski JR, Uyguner ZO, Below JE, Letra A. Whole-exome sequencing identifies novel variants for tooth agenesis. J Dent Res. 2018b;97(1):49–59.

    Article  CAS  Google Scholar 

  • Dong J, Amor D, Aldred MJ, Gu T, Escamilla M, MacDougall M. DLX3 mutation associated with autosomal dominant amelogenesis imperfecta with taurodontism. Am J Med Genet A. 2005;133(2):138–41.

    Article  Google Scholar 

  • Fernandez CCA, Pereira CVCA, Luiz RR, Faraco IM Jr, Marazita ML, Arnaudo M, de Carvalho FM, Poletta FA, Mereb JC, Castilla EE, Orioli IM, Costa MC, Vieira AR. Third molar agenesis as a potential marker for craniofacial deformities. Arch Oral Biol. 2018;88:19–23.

    Article  Google Scholar 

  • Friedman JW. The prophylactic extraction of third molars: a public health hazard. Am J Public Health. 2007;97(9):1554–9.

    Article  Google Scholar 

  • García-Hernández F, Toro YO, Veja VM, Verdejo MM. Agenesia del tercer molar en jóvenes entre 14 y 20 ānos de edad, Antofagasta, Chile. Int J Morphol. 2008;26(4):825–32.

    Article  Google Scholar 

  • Karasawa LH, Rossi AC, Groppo FC, Prado FB, Caria PHF. Cross-sectional study of correlation between mandibular incisor crowding and third molars in young Brazilians. Med Oral Patol Oral Cir Bucal. 2013;18(3):e505–9.

    Article  Google Scholar 

  • Küchler EC, Risso PA, Costa MC, Modesto A, Vieira AR. Assessing the proposed association between tooth agenesis and taurodontism in 975 pediatric subjects. Int J Paediatr Dent. 2008;18:231–4.

    Article  Google Scholar 

  • Küchler EC, Lips A, Tannure PN, Ho B, Costa MC, Granjeiro JM, Vieira AR. Tooth agenesis association with self-reported family history of cancer. J Dent Res. 2013;92(2):149–55.

    Article  Google Scholar 

  • Lai PY, Seow WK. A controlled study of the association of various dental anomalies with hypodontia of permanent teeth. Pediatr Dent. 1989;11(4):291–6.

    CAS  PubMed  Google Scholar 

  • Lammi L, Arte S, Somer M, Jarvinen H, Lahermo P, Thessleff I, Pirinen S, Nieminen P. Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am J Hum Genet. 2004;74(5):1043–50.

    Article  CAS  Google Scholar 

  • Letra A, Menezes R, Granjeiro JM, Vieira AR. Defining subphenotypes for oral clefts based on dental development. J Dent Res. 2007;86(10):986–91.

    Article  CAS  Google Scholar 

  • Liu X, Chen J, Liu J, Xu H, Fan C. A statistic analysis on absence of third molar germs in orthodontic patients. West China J Stomatol. 2004;22(6):493–5.

    Google Scholar 

  • Lu X, Yu F, Liu J, Cai W, Zhao Y, Zhao S, Liu S. The epidemiology of supernumerary teeth and the associated molecular mechanism. Organogenesis. 2017;13(3):71–82.

    Article  CAS  Google Scholar 

  • Pippi R. Odontomas and supernumerary teeth: is there a common origin? Int J Med Sci. 2014;11(12):1282–97.

    Article  Google Scholar 

  • Pitekova L, Satko L. Controversy of the third molars. Bratisl Lek Listy. 2009;110(2):110–1.

    CAS  PubMed  Google Scholar 

  • Schalk-van der Weid Y, Steen WH, Bosman F. Taurodontism and length of teeth in patients with oligodontia. J Oral Rehabil. 1993;20(4):401–12.

    Article  Google Scholar 

  • Seow WK, Lai PY. Association of taurodontism with hypodontia: a controlled study. Pediatr Dent. 1989;11(3):214–9.

    CAS  PubMed  Google Scholar 

  • Stanley HR, Alattar M, Colett WK, Stringfellow HR Jr, Spiegel EH. Pathological sequelae of “neglected” impacted third molars. J Oral Pathol. 1988;17(3):113–7.

    Article  CAS  Google Scholar 

  • Takahashi M, Hosomichi K, Yamaguchi T, Yano K, Funatsu T, Adel M, Haga S, Maki K, Tajima A. Whole-exome sequencing analysis of supernumerary teeth occurrence in Japanese individuals. Hum Genome Var. 2017;4:16046.

    Article  CAS  Google Scholar 

  • Tannure PN, Küchler EC, Pedro RL, Costa MC, Vieira AR. Dens evaginatus associated with dens invaginatus: a rare case with affected maxillary lateral incisors. Pediatric Dent J. 2008;18(2):192–5.

    Article  Google Scholar 

  • Thesleff I. Epithelial-mesenchymal signaling regulating tooth morphogenesis. J Cell Sci. 2003;116(9):1647–8.

    Article  CAS  Google Scholar 

  • Valmaseda-Castellon E, Berini-Aytes L, Gay-Escoda C. Inferior alveolar nerve damage after lower third molar surgical extraction: a prospective study of 1117 surgical extractions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92(4):377–83.

    Article  CAS  Google Scholar 

  • Vieira AR. Oral clefts and syndromic forms of tooth agenesis as models for genetics of isolated tooth agenesis. J Dent Res. 2003;82:162–5.

    Article  CAS  Google Scholar 

  • Vieira AR, Babb LM. Detection of carotid artery plaque in the dental setting. Open J Stomatol. 2012;2:136–9.

    Article  Google Scholar 

  • Vieira AR, Meira R, Modesto A, Murray JC. MSX1, PAX9, and TGFA contribute to tooth agenesis in humans. J Dent Res. 2004;83:723–7.

    Article  CAS  Google Scholar 

  • Williams MA, Letra A. The changing landscape in the genetic etiology of human tooth agenesis. Genes (Basel). 2018;9(5):255.

    Article  Google Scholar 

  • Zeng B, Lu H, Xiao X, Yu X, Li S, Zhu L, Yu D, Zhao W. KDF1 is a novel candidate gene of non-syndromic tooth agenesis. Arch Oral Biol. 2019;97(1):131–6.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Oral Biology, University of Pittsburgh, Pittsburgh, PA, USA

    Alexandre Rezende Vieira

Authors
  1. Alexandre Rezende Vieira
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Vieira, A.R. (2019). Genetic Basis of Tooth Agenesis, Supernumerary Teeth, and Other Dental Abnormalities. In: Genetic Basis of Oral Health Conditions. Springer, Cham. https://doi.org/10.1007/978-3-030-14485-2_3

Download citation

Publish with us

Policies and ethics

Search

Navigation