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Trigeminal Mechanisms of Nociception

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Neuromodulation in Headache and Facial Pain Management

Part of the book series: Headache ((HEAD))

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Abstract

The trigeminal nerve (Vn) is the largest cranial nerve and it supplies sensory fibres to all craniofacial structures. Sensory innervation of the craniofacial region is important in functional, psychological and emotional aspects, given the significance of the head as an organ in whole, of facial communication and of all specialised sense organs of the head such as the retina, olfactory epithelium, taste papillae, tooth pulp and cochlea, which are highly innervated by trigeminal fibres [1]. Trigeminal fibres are organised to warn the organism against changing environmental conditions, ranging from changes in environmental chemicals, temperature, injury or other external stimuli. The craniofacial region has a rich innervation and an extensive somatosensory representation in the CNS. These aspects make the Vn the most complex of the 12 cranial nerves. Mechanisms of nociception along the trigeminal nerve are of particular interest in headache conditions and orofacial pain [2].

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Author information

Authors and Affiliations

  1. Headache Research, Wolfson Centre for Age Related Disorder, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK

    Anna P. Andreou

  2. Headache Centre, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

    Anna P. Andreou

  3. Department of Internal Medicine, Institute of Clinical Sciences, Lund University, Lund, Sweden

    Lars Edvinsson

Authors
  1. Anna P. Andreou
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  2. Lars Edvinsson
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Correspondence to Anna P. Andreou .

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Editors and Affiliations

  1. Headache Centre, Guy’s and St Thomas’, NHS Foundation Trust, Pain Management and Neuromodulation Centre and Neurology Department, London, UK

    Giorgio Lambru

  2. Department de Traitement de la douleur, Centre Hospitalier Universitaire de Nice, Department de Traitement de la douleur, Nice, France

    Michel Lanteri-Minet

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Andreou, A.P., Edvinsson, L. (2020). Trigeminal Mechanisms of Nociception. In: Lambru, G., Lanteri-Minet, M. (eds) Neuromodulation in Headache and Facial Pain Management. Headache. Springer, Cham. https://doi.org/10.1007/978-3-030-14121-9_1

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