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Immunohistochemistry in Prostate Biopsy Evaluation

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Prostate Biopsy Interpretation

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Abstract

Immunohistochemistry is widely used in the work-up of difficult prostate biopsies. It is used principally in two clinical settings: to distinguish prostate cancer from benign lesions that mimic cancer, and to distinguish poorly differentiated prostate cancer from other malignant tumors that can occasionally involve the prostate, including urothelial carcinoma and colonic adenocarcinoma. Immunohistochemistry, as an adjunct to histological examination, has had significant impact on the prostate biopsy evaluation. In the case of limited cancer or histological variants with deceptively bland morphology, immunohistochemistry is an indispensible part of the work-up. Use of immunohistochemistry has also significantly reduced the incidence of prostate biopsies with atypical diagnosis to establish a definitive diagnosis. Many immunohistochemical biomarkers have been investigated for prognostic purposes and risk stratification; however, none has been sufficiently validated for routine clinical use.

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Authors and Affiliations

  1. Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA

    Rajal B. Shah

  2. Tufts Medical Center, Boston, MA, USA

    Ming Zhou

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  1. Rajal B. Shah
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Correspondence to Rajal B. Shah .

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Shah, R.B., Zhou, M. (2019). Immunohistochemistry in Prostate Biopsy Evaluation. In: Prostate Biopsy Interpretation. Springer, Cham. https://doi.org/10.1007/978-3-030-13601-7_4

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  • DOI: https://doi.org/10.1007/978-3-030-13601-7_4

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-13600-0

  • Online ISBN: 978-3-030-13601-7

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