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Relevance of Flammer Syndrome to the “Sleep-Wake” Rhythm: Possible Mechanisms, Risks and Preventive Strategies

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Flammer Syndrome

Part of the book series: Advances in Predictive, Preventive and Personalised Medicine ((APPPM,volume 11))

Abstract

Sleep and chronobiology have decisive effects on human health and disease status. Chronobiology is relatively recently recognised as a prominent scientific area, particularly as in 2017 three American researchers received the Nobel Prize for their discoveries on molecular mechanisms behind the internal clocks and biological rhythms that govern human lifes. Genetic make-up responsible for the self-sustaining clockwork inside the cell regulating fundamental functions such as behaviour, hormone levels, sleep, body temperature and metabolism has been discovered. Research data demonstrate that sleep is connected to cell regeneration, detoxification of the body, memory consolidation, and psychological recovery. Consequently, being in a state of sleep deficit can be dangerous; short sleep duration correlates with increased risk of cardiovascular and metabolic diseases, and untreated insomnia can lead to severe depression. Many people think that if they sleep less, they can work more. But the truth is that self-induced short sleep leads to impaired work ability. Car accidents, work accidents, as well as impaired concentration - all may result from the sleep deprivation. Pathomechanisms of severe neurological disorders have been demonstrated as being connected to impaired sleep patterns. Noteworthy, highly increased mortality, due to accidents generally, car accidents in particular, sleep disorders, depression and neurodegenerative impairments have been recorded specifically for individuals with low BMI (see the introductory chapter “Flammer Syndrome in the Global Context – The “U-Shape” of Health Risks”).

This chapter highlights mechanisms of the sleep patterns alteration characteristic for the FS affected individuals, discusses a potential link between the long-term consequences and increased risks of exemplified pathologies and provides expert recommendation for effective PPPM strategies applied to sleep medicine.

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Abbreviations

PVD:

primary vascular dysregulation

TDCE:

thermal discomfort from cold extremities

DLMO:

Dim Light Onset Melatonin

SCN:

suprachiasmatic nucleus

NTG:

normal tension Glaucoma

BMI:

body mass index

FS:

Flammer Syndrome

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Author information

Authors and Affiliations

  1. University Clinic for Psychiatry and Psychotherapy, Paracelsus Medical University Nuremberg, Nuremberg, Germany

    Kneginja Richter, Lukas Peter, Thomas Hillemacher & Günter Niklewski

  2. Faculty for Social Work, Technical University Georg Simon Ohm Nuremberg, Nuremberg, Germany

    Kneginja Richter

  3. Faculty for Medical Sciences, Unversity Goce Delcev Stip, Stip, Macedonia

    Kneginja Richter, Lence Miloseva & Günter Niklewski

  4. Radiological Clinic, Rheinische Friedrich-Wilhelms-University of Bonn, Bonn, Germany

    Olga Golubnitschaja

  5. Breast Cancer Research Centre, Rheinische Friedrich-Wilhelms-University of Bonn, Bonn, Germany

    Olga Golubnitschaja

  6. Centre for Integrated Oncology, Cologne-Bonn, Rheinische Friedrich-Wilhelms-University of Bonn, Bonn, Germany

    Olga Golubnitschaja

Authors
  1. Kneginja Richter
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  2. Lukas Peter
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  3. Lence Miloseva
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  4. Thomas Hillemacher
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  5. Günter Niklewski
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  6. Olga Golubnitschaja
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Corresponding author

Correspondence to Kneginja Richter .

Editor information

Editors and Affiliations

  1. Department of Radiology, Friedrich-Wilhelms-University in Bonn, Bonn, Nordrhein-Westfalen, Germany

    Olga Golubnitschaja

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Richter, K., Peter, L., Miloseva, L., Hillemacher, T., Niklewski, G., Golubnitschaja, O. (2019). Relevance of Flammer Syndrome to the “Sleep-Wake” Rhythm: Possible Mechanisms, Risks and Preventive Strategies. In: Golubnitschaja, O. (eds) Flammer Syndrome. Advances in Predictive, Preventive and Personalised Medicine, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-030-13550-8_8

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  • DOI: https://doi.org/10.1007/978-3-030-13550-8_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-13549-2

  • Online ISBN: 978-3-030-13550-8

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