Skip to main content
SpringerLink
Log in

Interrelation Between Dry Mouth and Flammer Syndromes: Neglected Risks in Youth and New Concepts of Personalised Prevention

International Multi-centre Study

  • Chapter
  • First Online:
Flammer Syndrome

Part of the book series: Advances in Predictive, Preventive and Personalised Medicine ((APPPM,volume 11))

  • 283 Accesses

Abstract

“Dry mouth” syndrome (chronic hyposalivation) can be caused by a number of pathophysiological conditions such as acute and chronic stress exposure, abnormal body weight (both – too high and too low), eating disorders (such as Anorexia nervosa), metabolic syndrome(s), Sjögren’s and Sicca syndromes, drugs and head/neck radiotherapy application. In turn, the chronic hyposalivation as a suboptimal health condition significantly reduces quality of life, may indicate a systemic dehydration, provoke and contribute to a number of pathologies such as a strongly compromised protection of the oral cavity, chronic infections and inflammatory processes, periodontitis, voice and digestive disorders, amongst others. Consequently, “dry mouth” syndrome might be extremely useful as an indicator for an in-depth diagnostics of both – co-existing and snowballing health-threating conditions. However, predictive diagnostics, targeted prevention and personalisation of treatments are evidently underdeveloped for individuals at high risk suffering from the “dry mouth” syndrome.

In our presented study, for both – the target group (hyposalivation) and positive control (periodontitis), FS-phenotype was demonstrated to be more specific compared to the disease-free (negative control) group. Moreover, self-reports provided by interviewed young individuals of the target group frequently recorded remarkable discomfort related to “dry mouth” syndrome, acute and chronic otorhinolaryngological infections, and even delayed wound healing. Further, interviewed individuals do worry about these symptoms which might be indicative for potential diseases; they are also amazed that too little attention is currently paid to the issue by caregivers.

Epi/genetic regulations involved into pathophysiologic mechanisms of hyposalivation in FS-affected individuals should be thoroughly investigated at molecular level. Identified biomarker-panels might be of great clinical utility for predictive diagnostics and patient stratification that would sufficiently improve personalised care to the affected individuals.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Pedersen AML, Sørensen CE, Proctor GB, Carpenter GH (2018) Salivary functions in mastication, taste and textural perception, swallowing and initial digestion. Oral Dis. https://doi.org/10.1111/odi.12867

    Article  PubMed  Google Scholar 

  2. Berk LB, Shivnani AT, Small W (2005) Pathophysiology and management of radiation-induced xerostomia. J Support Oncol 3:191–200

    CAS  PubMed  Google Scholar 

  3. Mileguir D, Golubnitschaja O (2017) Human saliva as a powerful source of information: multi-omics biomarker panels, In: EPMA world congress: traditional forum in predictive, preventive and personalised medicine for multi-professional consideration and consolidation. EPMA J 8:1–54. https://doi.org/10.1007/s13167-017-0108-4

    Article  Google Scholar 

  4. Carramolino-Cuéllar E, Lauritano D, Silvestre F-J, Carinci F, Lucchese A, Silvestre-Rangil J (2018) Salivary flow and xerostomia in patients with type 2 diabetes. J Oral Pathol Med Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol 47:526–530. https://doi.org/10.1111/jop.12712

    Article  Google Scholar 

  5. Nederfors T (2000) Xerostomia and hyposalivation. Adv Dent Res 14:48–56. https://doi.org/10.1177/08959374000140010701

    Article  CAS  PubMed  Google Scholar 

  6. Sreebny LM (2000) Saliva in health and disease: an appraisal and update. Int Dent J 50:140–161

    Article  CAS  PubMed  Google Scholar 

  7. Shigeyama C, Ansai T, Awano S, Soh I, Yoshida A, Hamasaki T et al (2008) Salivary levels of cortisol and chromogranin A in patients with dry mouth compared with age-matched controls. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:833–839. https://doi.org/10.1016/j.tripleo.2008.07.005

    Article  PubMed  Google Scholar 

  8. Kisely S (2016) No mental health without oral health. Can J Psychiatr Rev Can Psychiatr 61:277–282. https://doi.org/10.1177/0706743716632523

    Article  Google Scholar 

  9. Bulthuis MS, Jan Jager DH, Brand HS (2018) Relationship among perceived stress, xerostomia, and salivary flow rate in patients visiting a saliva clinic. Clin Oral Investig. https://doi.org/10.1007/s00784-018-2393-2

    Article  PubMed  PubMed Central  Google Scholar 

  10. Both T, Dalm VASH, van Hagen PM, van Daele PLA (2017) Reviewing primary Sjögren’s syndrome: beyond the dryness – from pathophysiology to diagnosis and treatment. Int J Med Sci 14:191–200. https://doi.org/10.7150/ijms.17718

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Vaillancourt T, Duku E, Decatanzaro D, Macmillan H, Muir C, Schmidt LA (2008) Variation in hypothalamic-pituitary-adrenal axis activity among bullied and non-bullied children. Aggress Behav 34:294–305. https://doi.org/10.1002/ab.20240

    Article  PubMed  Google Scholar 

  12. Gonzales JA, Chou A, Rose-Nussbaumer JR, Bunya VY, Criswell LA, Shiboski CH et al (2018) How are ocular signs and symptoms of dry eye associated with depression in women with and without Sjögren syndrome? Am J Ophthalmol 191:42–48. https://doi.org/10.1016/j.ajo.2018.04.004

    Article  PubMed  PubMed Central  Google Scholar 

  13. Golubnitschaja O (2017) Feeling cold and other underestimated symptoms in breast cancer: anecdotes or individual profiles for advanced patient stratification? EPMA J 8:17–22. https://doi.org/10.1007/s13167-017-0086-6

    Article  PubMed  PubMed Central  Google Scholar 

  14. Zubor P, Gondova A, Polivka J, Kasajova P, Konieczka K, Danko J et al (2017) Breast cancer and Flammer syndrome: any symptoms in common for prediction, prevention and personalised medical approach? EPMA J 8:129–140. https://doi.org/10.1007/s13167-017-0089-3

    Article  PubMed  PubMed Central  Google Scholar 

  15. Konieczka K, Ritch R, Traverso CE, Kim DM, Kook MS, Gallino A et al (2014) Flammer syndrome. EPMA J 5:11. https://doi.org/10.1186/1878-5085-5-11

    Article  PubMed  PubMed Central  Google Scholar 

  16. Bubnov R, Polivka J, Zubor P, Konieczka K, Golubnitschaja O (2017) “Pre-metastatic niches” in breast cancer: are they created by or prior to the tumour onset? “Flammer Syndrome” relevance to address the question. EPMA J 8:141–157. https://doi.org/10.1007/s13167-017-0092-8

    Article  PubMed  PubMed Central  Google Scholar 

  17. Carpenter G (ed) Challacombe SJ, Osailan SM, Proctor GB (2015) Clinical scoring scales for assessment of dry mouth. In: Dry mouth: a clinical guide on causes, effects and treatments [Internet]. Springer, Berlin/Heidelberg. [cited 2018 July 12]. Available from: http://www.springer.com/us/book/9783642551536

  18. Flammer Syndrome [Internet]. [cited 2018 Jul 12]. Available from: http://www.flammer-syndrome.ch/index.php?id=32

  19. Konieczka K, Choi HJ, Koch S, Schoetzau A, Küenzi D, Kim DM (2014) Frequency of symptoms and signs of primary vascular dysregulation in Swiss and Korean populations. Klin Monatsbl Augenheilkd 231:344–347. https://doi.org/10.1055/s-0034-1368239

    Article  CAS  PubMed  Google Scholar 

  20. Smokovski I, Risteski M, Polivka J, Zubor P, Konieczka K, Costigliola V et al (2017) Postmenopausal breast cancer: European challenge and innovative concepts. EPMA J 8:159–169. https://doi.org/10.1007/s13167-017-0094-6

    Article  PubMed  PubMed Central  Google Scholar 

  21. Konieczka K, Todorova MG, Chackathayil TN, Henrich PB (2015) Cilioretinal artery occlusion in a young patient with flammer syndrome and increased retinal venous pressure. Klin Monatsbl Augenheilkd 232:576–578. https://doi.org/10.1055/s-0035-1545774

    Article  CAS  PubMed  Google Scholar 

  22. Konieczka K, Flammer J, Sternbuch J, Binggeli T, Fraenkl S (2017) Leber’s hereditary optic neuropathy, normal tension glaucoma, and Flammer syndrome: long term follow-up of a patient. Klin Monatsbl Augenheilkd 234:584–587. https://doi.org/10.1055/s-0042-119564

    Article  CAS  PubMed  Google Scholar 

  23. Baban B, Golubnitschaja O (2017) The potential relationship between Flammer and Sjögren syndromes: the chime of dysfunction. EPMA J 8:333–338. https://doi.org/10.1007/s13167-017-0107-5

    Article  PubMed  PubMed Central  Google Scholar 

  24. Change the World – One article at a time [Internet]. [cited 2018 July 12]. Available from: https://www.springernature.com/gp/researchers/campaigns/change-the-world?wt_mc=SocialMedia.Twitter.10.CON417.ctw2018_tw_shared_button&utm_medium=socialmedia&utm_source=twitter&utm_content=ctw2018_tw_shared_button&utm_campaign=10_dann_ctw2018_tw_shared_button

  25. Change the World – Medicine and Public Health [Internet]. [cited 2018 July 12]. Available from: https://www.springernature.com/gp/researchers/campaigns/change-the-world/medicine-public-health

  26. LeBlanc TW, Abernethy AP (2017) Patient-reported outcomes in cancer care – hearing the patient voice at greater volume. Nat Rev Clin Oncol 14:763–772. https://doi.org/10.1038/nrclinonc.2017.153

    Article  PubMed  Google Scholar 

  27. Golubnitschaja O, Flammer J (2018) Individualised patient profile: clinical utility of Flammer syndrome phenotype and general lessons for predictive, preventive and personalised medicine. EPMA J 9:15–20. https://doi.org/10.1007/s13167-018-0127-9

    Article  PubMed  PubMed Central  Google Scholar 

  28. Orellana MF, Lagravère MO, Boychuk DGJ, Major PW, Flores-Mir C (2006) Prevalence of xerostomia in population-based samples: a systematic review. J Public Health Dent 66:152–158

    Article  CAS  PubMed  Google Scholar 

  29. da Luz Neto LM , de Vasconcelos FMNda Silva JE, Pinto TCC, Sougey ÉB, Ximenes RCC. Differences in cortisol concentrations in adolescents with eating disorders: a systematic review. J Pediatr 2018; pii: S0021-7557(18)30076-7. doi: https://doi.org/10.1016/j.jped.2018.02.007

    Article  PubMed  Google Scholar 

  30. Naik PN, Kiran RA, Yalamanchal S, Kumar VA, Goli S, Vashist N (2014) Acupuncture: an alternative therapy in dentistry and its possible applications. Med Acupunct 26:308–314. https://doi.org/10.1089/acu.2014.1028

    Article  PubMed  PubMed Central  Google Scholar 

  31. Blom M, Lundeberg T, Dawidson I, Angmar-Månsson B (1993) Effects on local blood flux of acupuncture stimulation used to treat xerostomia in patients suffering from Sjögren’s syndrome. J Oral Rehabil 20:541–548

    Article  CAS  PubMed  Google Scholar 

  32. Bayat-Movahed S, Shayesteh Y, Mehrizi H, Rezayi S, Bamdad K, Golestan B et al (2008) Effects of Qigong exercises on 3 different parameters of human saliva. Chin J Integr Med 14:262–266. https://doi.org/10.1007/s11655-008-0262-6

    Article  PubMed  Google Scholar 

  33. Zhang J, Zhong L-J, Wang Y, Liu L-M, Cong X, Xiang R-L et al (2017) Proteomic analysis reveals an impaired Ca2+/AQP5 pathway in the submandibular gland in hypertension. Sci Rep 7:14524. https://doi.org/10.1038/s41598-017-15211-0

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Gabryś HS, Buettner F, Sterzing F, Hauswald H, Bangert M (2018) Design and selection of machine learning methods using radiomics and dosiomics for normal tissue complication probability modeling of xerostomia. Front Oncol 8:35. https://doi.org/10.3389/fonc.2018.00035

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dentistry Faculty, Departments of Maxillofacial Surgery and Hospital Dentistry, Voronezh N.N. Burdenko State Medical University, Voronezh, Russia

    Analtolij Kunin & Natalia Moiseeva

  2. Department of Histology and Embryology and Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic

    Jiri Polivka Jr

  3. Department of Neurology, University Hospital Pilsen, Pilsen, Czech Republic

    Jiri Polivka Jr

  4. Radiological Clinic, UKB, Rheinische Friedrich-Wilhelms-University of Bonn, Bonn, Germany

    Olga Golubnitschaja

  5. Breast Cancer Research Centre, UKB, Rheinische Friedrich-Wilhelms-University of Bonn, Bonn, Germany

    Olga Golubnitschaja

  6. Centre for Integrated Oncology, Cologne-Bonn, Rheinische Friedrich-Wilhelms-University of Bonn, Bonn, Germany

    Olga Golubnitschaja

Authors
  1. Analtolij Kunin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jiri Polivka Jr
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Natalia Moiseeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Olga Golubnitschaja
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Olga Golubnitschaja .

Editor information

Editors and Affiliations

  1. Department of Radiology, Friedrich-Wilhelms-University in Bonn, Bonn, Nordrhein-Westfalen, Germany

    Olga Golubnitschaja

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kunin, A., Polivka, J., Moiseeva, N., Golubnitschaja, O. (2019). Interrelation Between Dry Mouth and Flammer Syndromes: Neglected Risks in Youth and New Concepts of Personalised Prevention. In: Golubnitschaja, O. (eds) Flammer Syndrome. Advances in Predictive, Preventive and Personalised Medicine, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-030-13550-8_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-13550-8_6

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-13549-2

  • Online ISBN: 978-3-030-13550-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation