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“Young Stroke” Risks Potentially Linked to the Flammer Syndrome Phenotype: Facts and Hypotheses

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Flammer Syndrome

Part of the book series: Advances in Predictive, Preventive and Personalised Medicine ((APPPM,volume 11))

Abstract

Currently, the stroke is registered amongst the five leading causes of death and disability worldwide. From the European perspective approximately 1.1 million individuals become stroke diagnosed each year. The disorder demonstrates severe socioeconomic consequences: the associated total EU costs are as high as €45 billion annually.

Even if the majority of the stroke cases are diagnosed in the elderly, about 10% of all patients experience the disorder at the age below 50 years – so-called “young strokes”. Moreover, the incidence as well prevalence of stroke in young adults is dramatically increasing worldwide. Further, the proportion of strokes with unknown etiology among the youngest subgroup of patients reaches up to 39.6–42% that remains largely unexplained. Therefore, specifically modifiable risk factors such as suboptimal heath conditions are proposed to be considered for innovative risk assessment in the “young stroke” prediction and prevention.

Due to symptoms characteristic for the Flammer syndrome (FS), we hypothesised a potential relationship between FS phenotype and increased risks for the “young stroke” predisposition. FS characteristic symptoms and signs analysed in the chapter may further synergistically contribute to the cerebrovascular events being potentially indicative for the stroke predisposition in young individuals.

If the hypothesised association become confirmed by multi-centre studies run, FS phenotype may get of great clinical utility for creating innovative strategies of predictive, preventive and personalised medicine for the stroke management utilising novel screening programmes, individualised patient profiling, specialised questionnaires and novel biomarker patterns for an effective risk assessment, targeted prevention, and therapy monitoring tailored to the person.

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Authors and Affiliations

  1. Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic

    Jiri Polivka Jr

  2. Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic

    Jiri Polivka Jr & Martin Pesta

  3. Department of Neurology, University Hospital Pilsen, and Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic

    Jiri Polivka Jr, Jiri Polivka & Vladimir Rohan

  4. Department of Biology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic

    Martin Pesta

  5. Department of Social and Assessment Medicine, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic

    Libuse Celedova & Rostislav Cevela

  6. Department of Immunochemistry, University Hospital Pilsen, Pilsen, Czech Republic

    Ondrej Topolcan

  7. Radiological Clinic, UKB, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany

    Olga Golubnitschaja

  8. Breast Cancer Research Centre, UKB, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany

    Olga Golubnitschaja

  9. Centre for Integrated Oncology, Cologne-Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany

    Olga Golubnitschaja

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    Olga Golubnitschaja

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Polivka, J. et al. (2019). “Young Stroke” Risks Potentially Linked to the Flammer Syndrome Phenotype: Facts and Hypotheses. In: Golubnitschaja, O. (eds) Flammer Syndrome. Advances in Predictive, Preventive and Personalised Medicine, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-030-13550-8_10

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  • DOI: https://doi.org/10.1007/978-3-030-13550-8_10

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