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New Achievements in Continuum Mechanics and Thermodynamics pp 29–49Cite as

The Effect of Mechanical Load-induced Intraosseous Pressure Gradients on Bone Remodeling

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Part of the book series: Advanced Structured Materials ((STRUCTMAT,volume 108))

Abstract

It is well established that changes in bone blood and interstitial fluid flows are associated with changes in the bone remodeling process. These flows in bone are a result not only of trans-cortical pressure gradients produced by vascular and hydro-static pressure, but also of mechanical loadings. Mechanical load-induced intraosseous pressure gradients may result in some fluid stimuli effects which, in turn, may enable bone cells to detect external mechanical signals. In this paper, the exploitation of a 2D continuum model based on classical poroelasticity is presented within a variational framework. The investigation is aimed at describing how mechanical actions can affect the remodeling process of a bone tissue. The focus is on the introduction of a physically motivated strain energy contribution aimed to take into account the presence of saturating fluid in the interconnected pores of bone tissue. The interaction with a bio-resorbable organic ceramic material like those used in bone graft implants is also considered in presented model. Numerical results are provided in a relevant exemplary case.

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Authors and Affiliations

  1. Department of Structural and Geotechnical Engineering, Università degli studi di Roma La Sapienza, 18 Via Eudossiana, Rome, Italy

    Emilio Barchiesi & Ivan Giorgio

  2. International Research Center for the Mathematics and Mechanics of Complex Systems - MeMoCS, Università degli studi dell’Aquila, L’Aquila, Italy

    Emilio Barchiesi & Ivan Giorgio

  3. NAAM Research Group, Department of Mathematics, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

    Faris Alzahrani & Tasawar Hayat

  4. Department of Mathematics, Quaid-I-Azam University, Islamabad, Pakistan

    Tasawar Hayat

Authors
  1. Emilio Barchiesi
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  2. Ivan Giorgio
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  3. Faris Alzahrani
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  4. Tasawar Hayat
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Corresponding author

Correspondence to Emilio Barchiesi .

Editor information

Editors and Affiliations

  1. Institute of Mechanics, Technische Universität Berlin, Berlin, Germany

    Bilen Emek Abali

  2. Institut für Mechanik, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany

    Holm Altenbach

  3. Dipartimento di Ingegneria Strutturale e Geotecnica, Università degli Studi di Roma “La Sapienza”, Roma, Italy

    Francesco dell'Isola

  4. Faculty of Civil and Environmental Engineering, Gdansk University of Technology, Gdansk, Poland

    Victor A. Eremeyev

  5. Fakultät Maschinenbau, Esslingen University of Applied Sciences, Esslingen, Germany

    Andreas Öchsner

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Barchiesi, E., Giorgio, I., Alzahrani, F., Hayat, T. (2019). The Effect of Mechanical Load-induced Intraosseous Pressure Gradients on Bone Remodeling. In: Abali, B., Altenbach, H., dell'Isola, F., Eremeyev, V., Öchsner, A. (eds) New Achievements in Continuum Mechanics and Thermodynamics. Advanced Structured Materials, vol 108. Springer, Cham. https://doi.org/10.1007/978-3-030-13307-8_3

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