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Human Skin: Composition, Structure and Visualisation Methods

  • Helen K. Graham
  • Alexander Eckersley
  • Matiss Ozols
  • Kieran T. Mellody
  • Michael J. SherrattEmail author
Chapter
Part of the Studies in Mechanobiology, Tissue Engineering and Biomaterials book series (SMTEB, volume 22)

Abstract

In this chapter we discuss the molecular composition and structure of the epidermis, dermal-epidermal junction, dermis and hypodermis. We highlight the contribution of long-lived dermal collagens, elastic fibres, proteoglycans and hyaluronic acid to skin function and also consider the role of apparently “minor” skin components. In order to characterise both healthy skin, and the progression of disease and ageing, it is necessary to use microscopical approaches but in addition to conventional ex vivo techniques, which image in two dimensions, valuable information can be gained by complimentary non-invasive and 3D imaging technologies.

Keywords

Skin structure Skin composition Epidermis Dermis Microscopy Non-invasive imaging Micro-computed X-ray tomography (microCT) 

Notes

Acknowledgements

The authors would like to acknowledge the generous financial support of Walgreens Boots Alliance.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Helen K. Graham
    • 1
  • Alexander Eckersley
    • 2
  • Matiss Ozols
    • 2
  • Kieran T. Mellody
    • 1
  • Michael J. Sherratt
    • 2
    Email author
  1. 1.Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and HealthThe University of ManchesterManchesterUK
  2. 2.Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and HealthThe University of ManchesterManchesterUK

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