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Physiological Genomics of Multistress Resistance in the Yeast Cell Model and Factory: Focus on MDR/MXR Transporters

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Yeasts in Biotechnology and Human Health

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 58))

Abstract

The contemporary approach of physiological genomics is vital in providing the indispensable holistic understanding of the complexity of the molecular targets, signalling pathways and molecular mechanisms underlying the responses and tolerance to stress, a topic of paramount importance in biology and biotechnology. This chapter focuses on the toxicity and tolerance to relevant stresses in the cell factory and eukaryotic model yeast Saccharomyces cerevisiae. Emphasis is given to the function and regulation of multidrug/multixenobiotic resistance (MDR/MXR) transporters. Although these transporters have been considered drug/xenobiotic efflux pumps, the exact mechanism of their involvement in multistress resistance is still open to debate, as highlighted in this chapter. Given the conservation of transport mechanisms from S. cerevisiae to less accessible eukaryotes such as plants, this chapter also provides a proof of concept that validates the relevance of the exploitation of the experimental yeast model to uncover the function of novel MDR/MXR transporters in the plant model Arabidopsis thaliana. This knowledge can be explored for guiding the rational design of more robust yeast strains with improved performance for industrial biotechnology, for overcoming and controlling the deleterious activities of spoiling yeasts in the food industry, for developing efficient strategies to improve crop productivity in agricultural biotechnology.

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Acknowledgements

Isabel Sá-Correia acknowledges all those who have, over the years, contributed to the fields of Yeast Physiological Genomics and Functional Analysis of Yeast MDR/MXR transporters in her Laboratory. Funding from ‘Fundação para a Ciência e a Tecnologia’ (FCT) (current project contracts: PTDC/BBB-BEP/0385/2014, YEASTPEC ERA-IB-2/003/2015 and Ph.D. and postdoctoral fellowships) and funding received by the Institute for Bioengineering and Biosciences (iBB) from POR Lisboa 2020 (Project No. 007317) and FCT (UID/BIO/04565/2013) are also acknowledged.

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    Cláudia P. Godinho & Isabel Sá-Correia

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    Isabel Sá-Correia

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Godinho, C.P., Sá-Correia, I. (2019). Physiological Genomics of Multistress Resistance in the Yeast Cell Model and Factory: Focus on MDR/MXR Transporters. In: Sá-Correia, I. (eds) Yeasts in Biotechnology and Human Health. Progress in Molecular and Subcellular Biology, vol 58. Springer, Cham. https://doi.org/10.1007/978-3-030-13035-0_1

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