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Cellular and Non-cellular Barriers to Particle Transport Across the Lungs

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Biological Responses to Nanoscale Particles

Part of the book series: NanoScience and Technology ((NANO))

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Abstract

Compared to the human body’s other outer epithelia, like e.g. the skin and the GI tract, the lungs have the largest surface area. Moreover, the so called “air-blood-barrier” is extremely thin, but also very tight to fulfill its physiological function. This chapter discusses the lung as a biological barrier in the context of inhaled particles. This important function is provided by some specific cellular as well as non-cellular elements. How the lung copes with particles “after landing” is not only relevant regarding the risks of accidentally inhaled nanomaterials, but also for designing safe and efficient nanopharmaceuticals to be inhaled on purpose.

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Authors and Affiliations

  1. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8 1, 66123, Saarbrücken, Germany

    Nicole Schneider-Daum, Marius Hittinger, Xabier Murgia & Claus-Michael Lehr

  2. PharmBioTec GmbH, Science Park 1, 66123, Saarbrücken, Germany

    Marius Hittinger & Claus-Michael Lehr

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  1. Nicole Schneider-Daum
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Correspondence to Nicole Schneider-Daum .

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  1. Institute of Anatomy, University of Bern, Bern, Switzerland

    Peter Gehr

  2. Institute of Physical Chemistry, University of Duisburg-Essen, Essen, Germany

    Reinhard Zellner

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Schneider-Daum, N., Hittinger, M., Murgia, X., Lehr, CM. (2019). Cellular and Non-cellular Barriers to Particle Transport Across the Lungs. In: Gehr, P., Zellner, R. (eds) Biological Responses to Nanoscale Particles. NanoScience and Technology. Springer, Cham. https://doi.org/10.1007/978-3-030-12461-8_7

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