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Calcium Signaling During Brain Aging and Its Influence on the Hippocampal Synaptic Plasticity

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Calcium Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1131))

Abstract

Calcium (Ca2+) ions are highly versatile intracellular signaling molecules and are universal second messenger for regulating a variety of cellular and physiological functions including synaptic plasticity. Ca2+ homeostasis in the central nervous system endures subtle dysregulation with advancing age. Research has provided abundant evidence that brain aging is associated with altered neuronal Ca2+ regulation and synaptic plasticity mechanisms. Much of the work has focused on the hippocampus, a brain region critically involved in learning and memory, which is particularly susceptible to dysfunction during aging. The current chapter takes a specific perspective, assessing various Ca2+ sources and the influence of aging on Ca2+ sources and synaptic plasticity in the hippocampus. Integrating the knowledge of the complexity of age-related alterations in neuronal Ca2+ signaling and synaptic plasticity mechanisms will positively shape the development of highly effective therapeutics to treat brain disorders including cognitive impairment associated with aging and neurodegenerative disease.

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Acknowledgements

Supported by National Institute of Aging grants R37AG036800, RO1AG049711, RO1AG037984, and RO1AG052258 and the Evelyn F. McKnight Brain Research Foundation.

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  1. Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, USA

    Ashok Kumar

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Correspondence to Ashok Kumar .

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  1. Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden

    Md. Shahidul Islam

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Kumar, A. (2020). Calcium Signaling During Brain Aging and Its Influence on the Hippocampal Synaptic Plasticity. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 1131. Springer, Cham. https://doi.org/10.1007/978-3-030-12457-1_39

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