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Calcium Signaling pp 605–623Cite as

Targeting Transient Receptor Potential Channels by MicroRNAs Drives Tumor Development and Progression

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1131))

Abstract

Transient receptor potential (TRP) cation channel superfamily plays important roles in a variety of cellular processes such polymodal cellular sensing, adhesion, polarity, proliferation, differentiation and apoptosis. The expression of TRP channels is strictly regulated and their de-regulation can stimulate cancer development and progression.

In human cancers, specific miRNAs are expressed in different tissues, and changes in the regulation of gene expression mediated by specific miRNAs have been associated with carcinogenesis. Several miRNAs/TRP channel pairs have been reported to play an important role in tumor biology. Thus, the TRPM1 gene regulates melanocyte/melanoma behaviour via TRPM1 and microRNA-211 transcripts. Both miR-211 and TRPM1 proteins are regulated through microphthalmia-associated transcription factor (MIFT) and the expression of miR-211 is decreased during melanoma progression. Melanocyte phenotype and melanoma behaviour strictly depend on dual TRPM1 activity, with loss of TRPM1 protein promoting melanoma aggressiveness and miR-211 expression supporting tumour suppressor. TRPM3 plays a major role in the development and progression of human clear cell renal cell carcinoma (ccRCC) with von Hippel-Lindau (VHL) loss. TRPM3, a direct target of miR-204, is enhanced in ccRCC with inactivated or deleted VHL. Loss of VHL inhibits miR-204 expression that lead to increased oncogenic autophagy. Therefore, the understanding of specific TRP channels/miRNAs molecular pathways in distinct tumors could provide a clinical rationale for target therapy in cancer.

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Abbreviations

BRAF:

proto-oncogene protein B-raf

BRAFV600 :

BRAF harbouring somatic missense mutations at the amino acid residue V600

BRN2:

POU-domain transcription factor (POU3F2)

ccRCC:

human clear cell renal cell carcinoma

CRC:

colorectal cancer

EC:

endometrial cancer

EOC:

epithelial ovarian cancer

ETS-1:

erythroblastosis virus E26 oncogene homolog 1

FGR2:

fibroblast growth factor receptor type 2

HCC:

hepatocellular carcinoma cells

LUAD:

lung adenocarcinoma

MIFT:

microphthalmia-associated transcription factor

miR:

MicroRNAs

mRNA:

messenger RNA

MTSS1:

metastasis suppressor gene 1

NCX1:

Na+/Ca2+ exchanger-1

NFAT5:

nuclear factor of activated T-cells 5

NFATC3:

nuclear factor of activated T-cells isoform c3

NSCLC:

non-small cell lung carcinoma

OC:

ovarian cancer

PCa:

prostate cancer

PKD:

Polycystic kidney disease

pri-miRs:

primary miRNAs

TrkB:

Tropomyosin receptor kinase B

TRPA:

Transient receptor potential ankyrin

TRPC:

Transient receptor potential canonical

TRPM:

Transient receptor potential melastatin

TRPP:

Transient receptor potential polycystic

TRPV:

Transient receptor potential vanilloid

UTR:

untranslated region

VHL:

von Hippel-Lindau

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Authors and Affiliations

  1. School of Pharmacy, Experimental Medicine Section, University of Camerino, Camerino, Italy

    Giorgio Santoni, Maria Beatrice Morelli, Massimo Nabissi & Oliviero Marinelli

  2. Clinic and Oncology Unit, Macerata Hospital, Macerata, Italy

    Matteo Santoni

  3. School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy

    Oliviero Marinelli & Consuelo Amantini

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  1. Giorgio Santoni
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  2. Maria Beatrice Morelli
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Correspondence to Giorgio Santoni .

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  1. Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden

    Md. Shahidul Islam

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Santoni, G., Morelli, M.B., Santoni, M., Nabissi, M., Marinelli, O., Amantini, C. (2020). Targeting Transient Receptor Potential Channels by MicroRNAs Drives Tumor Development and Progression. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 1131. Springer, Cham. https://doi.org/10.1007/978-3-030-12457-1_24

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