Some Observations About the Origin of the Pain in Cluster Headache

  • Trine NielsenEmail author
  • Arne May
  • Tim P. Jürgens
Part of the Headache book series (HEAD)


Given the clinical presentation and neuroscientific evidence, it is undisputed that the hypothalamus plays a central role in cluster headache (CH) pathogenesis [1, 2]. But does an activation of the hypothalamus suffice in generating the perception of pain or are peripheral structures required? This chapter revolves around the question of nociceptive input: where does the pain in CH originate from? This is a question which, as of yet, has no conclusive answer [2–5]. However, looking at previous research and clinical observations, we might be able to make some assumptions and pose some qualified guesses.


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Systems NeuroscienceUniversity Medical Centre Hamburg-EppendorfHamburgGermany
  2. 2.Department of NeurologyUniversity Medical Center RostockRostockGermany

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