Pathophysiological Considerations Regarding Cluster Headache and Trigeminal Autonomic Cephalalgias

  • Massimo LeoneEmail author
  • Arne May
Part of the Headache book series (HEAD)


When we discuss pathophysiological background regarding cluster headache, scientific progress over the last 20 years has put us in the fortunate situation that we can divide this question into “what drives cluster headache” and “where is the source of the pain.” For decades these (fundamentally different) questions have been mixed as so little was known about the pathophysiology of this dreadful disease. We have learned so much about modulators and generators of cluster headache attacks and—to be frank—know still relatively little of what structure actually generates the nociceptive input. We therefore focus here on central generating factors (the why) and refer to the Chaps.  8 and  9 in this book (the where) [1, 2].


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of NeurologyNeuroalgology Unit, The Foundation of the Carlo Besta Neurological Institute, IRCCSMilanoItaly
  2. 2.Department of Systems NeuroscienceUniversity of HamburgHamburgGermany

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