Future Therapies for Trigeminal Autonomic Cephalalgias: Cluster Headache and Related Conditions

  • Peter J. GoadsbyEmail author
  • Lars Edvinsson
Part of the Headache book series (HEAD)


The trigeminal autonomic cephalalgias (TACs) are a group of primary headache disorders linked by usually prominent cranial autonomic features [1] that when present are typically lateralized to the side of the pain [2]. The TACs are grouped under section 3 of the current International Classification of Headache Disorders-3 [3]. They consist of cluster headache [4], paroxysmal hemicrania [5], short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT)/cranial autonomic feature (SUNA) [6] and hemicrania continua [7]. These are devastating problems with patients describing the pain of cluster headache as the worst they have ever experienced [8].


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.NIHR-Wellcome Trust King’s Clinical Research Facility & SLaM Biomedical Research CentreKing’s College LondonLondonUK
  2. 2.Department of Internal MedicineUniversity of LundLundSweden

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