The Role of the Sphenopalatine Ganglion in Headache Conditions: New Insights

  • Erling TronvikEmail author
  • Rigmor Jensen
Part of the Headache book series (HEAD)


For more than 100 years, the sphenopalatine ganglion (SPG) has been targeted for the treatment of headache and facial pain. Several techniques have been used over the years to influence the activity in this neuronal structure, from intranasal cocaine to today’s implanted stimulators. Data collected throughout the years point in the direction of an important role of this parasympathetic ganglion in different primary headaches. The aim of the present chapter is to give an overview of the anatomy and physiology of this structure with relation to headache pathophysiology and in particular how it may be targeted to treat headache disorders.


Sphenopalatine ganglion Otic ganglion Cluster headache Migraine Autonomic nervous system 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Neuromedicine and Movement ScienceNTNU—Norwegian University of Science and TechnologyTrondheimNorway
  2. 2.Department of Neurology and Clinical NeurophysiologySt. Olavs HospitalTrondheimNorway
  3. 3.Neurological Clinic, Danish Headache Centre, Rigshospitalet-GlostrupUniversity of CopenhagenCopenhagenDenmark

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