Abstract
T-cell development occurs in the thymus in both mice and humans. Upon entry into the thymus, bone marrow-derived blood-borne progenitors receive instructive signals, including Notch signaling, to extinguish their potential to develop into alternative immune lineages while committing to the T-cell fate. Upon T-lineage commitment, developing T-cells receive further instructional cues to generate different T-cell sublineages, which together possess diverse immunological functions to provide host immunity. Over the years, numerous studies have contributed to a greater understanding of key thymic signals that govern T-cell differentiation and subset generation. Here, we review these critical signaling factors that govern the different stages of both mouse and human T-cell development, while also focusing on the transcriptional changes that mediate T-cell identity and diversity.
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Yoganathan, K., Chen, E.L.Y., Singh, J., Zúñiga-Pflücker, J.C. (2019). T-Cell Development: From T-Lineage Specification to Intrathymic Maturation. In: Passos, G. (eds) Thymus Transcriptome and Cell Biology. Springer, Cham. https://doi.org/10.1007/978-3-030-12040-5_4
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