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Bone Cysts Involving the Hip

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The Pediatric and Adolescent Hip

Abstract

Simple (unicameral) bone cyst (SBC) and aneurysmal bone cyst (ABC) are common benign bone tumors in children and adolescents. Although non-cancerous, they can cause substantive physical and psychosocial problems. Particularly for ABC, they mimic malignant tumors causing understandable anxiety and fear. As such, early and accurate diagnosis is essential. Primarily lytic lesions, they weaken the involved bones which predisposes to pathologic fractures, even with minimal trauma. Children are often restricted from sport and some daily living activities because of the fear of these fractures. Bone cysts involving the hip in children have special importance. Being a weight bearing joint, fractures in this area are a genuine risk, with concomitant occurrence of avascular necrosis being a concern. There are surgical challenges related to the pathoanatomy of these lesions, with only few surgical implants that can reliably stabilise the proximal femur without causing injury to the growth plate. This chapter provides an overview of both SBC and ABC, emphasizing currently accepted treatments and reported outcomes.

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References

  1. Alshryda S, Wright J. In: Alshryda H, editor. Chapter 44: Evidence based treatment for simple bone cyst. pediatric orthopaedics: an evidence-based approach to clinical questions. Banaszkiewicz: Springer; 2016. p. 51–75.

    Google Scholar 

  2. Virchow, R. Ueber die bildung von knochencysten ([On the formation of bony cysts) . Berlin, Germany: Monatsber d Kgl Akad D Wissenschaften. Sitzung der Phisikalischen-mathemat Klasse vom; 12 Juni; 1876. p. 369–381.

    Google Scholar 

  3. Lagier R, Kramar C, Baud CA. Femoral unicameral bone cyst in a medieval child. Radiological and pathological study. Pediatr Radiol. 1987;17(6):498–500.

    Article  CAS  PubMed  Google Scholar 

  4. Cohen J. Simple bone cysts. Studies of cyst fluid in six cases with a theory of pathogenesis. J Bone Joint Surg Am. 1960;42-A:609–16.

    Article  CAS  PubMed  Google Scholar 

  5. Chigira M, Maehara S, Arita S, Udagawa E. The aetiology and treatment of simple bone cysts. J Bone Joint Surg Br. 1983a;65(5):633–7.

    Article  CAS  PubMed  Google Scholar 

  6. Mirra JM, Bernard GW, Bullough PG, Johnston W, Mink G. Cementum-like bone production in solitary bone cysts (so-called “Cementoma” of long bones) report of three cases. electron microscopic observations supporting a synovial origin to the simple bone cyst. Clin Orthop Relat Res. 1978;135:295–307.

    Google Scholar 

  7. Yu CL, D'Astous J, Finnegan M. Simple bone cysts. The effects of methylprednisolone on synovial cells in culture. Clin Orthop Relat Res. 1991;262:34–41.

    Google Scholar 

  8. Richkind KE, Mortimer E, Mowery-Rushton P, Fraire A. Translocation (16;20)(p11.2;q13). Sole cytogenetic abnormality in a unicameral bone cyst. Cancer Genet Cytogenet. 2002;137(2):153–5.

    Article  CAS  PubMed  Google Scholar 

  9. Vayego SA, De Conti OJ, Varella-Garcia M. Complex cytogenetic rearrangement in a case of unicameral bone cyst. Cancer Genet Cytogenet. 1996;86(1):46–9.

    Article  CAS  PubMed  Google Scholar 

  10. Komiya S, Minamitani K, Sasaguri Y, Hashimoto S, Morimatsu M, Inoue A. Simple Bone Cyst. Clin Orthop Relat Res. 1993a;287:204–11.

    Google Scholar 

  11. Komiya S, Minamitani K, Sasaguri Y, Hashimoto S, Morimatsu M, Inoue A. Simple bone cyst. Treatment by trepanation and studies on bone resorptive factors in cyst fluid with a theory of its pathogenesis. Clin Orthop Relat Res. 1993b;287:204–11.

    Google Scholar 

  12. Herring JA. Tachdjians Pediatric Orthopaedics. Philadelphia: Saunders Elsevier; 2013.

    Google Scholar 

  13. Doganavsargil B, Ayhan E, Argin M, Pehlivanoglu B, Kececi B, Sezak M, Basdemir G, Oztop F. Cystic bone lesions: histopathological spectrum and diagnostic challenges. Turk Patoloji Derg. 2015;31(2):95–103.

    PubMed  Google Scholar 

  14. Shindell R, Connolly JF, Lippiello L. Prostaglandin levels in a unicameral bone cyst treated by corticosteroid injection. J Pediatr Orthop. 1987;7(2):210–2.

    Article  CAS  PubMed  Google Scholar 

  15. Shindell R, Huurman WW, Lippiello L, Connolly JF. Prostaglandin levels in unicameral bone cysts treated by Intralesional Steroid Injection. J Pediatr Orthop. 1989a;9(5):516–9.

    Article  CAS  PubMed  Google Scholar 

  16. Hart PH, Burgess DR, Vitti GF, Hamilton JA. Interleukin-4 stimulates human monocytes to produce tissue-type plasminogen activator. Blood. 1989;74(4):1222–5.

    CAS  PubMed  Google Scholar 

  17. Kobza Black A, Greaves MW, Hensby CN. The effect of systemic prednisolone on arachidonic acid, and prostaglandin E2 and F2 alpha levels in human cutaneous inflammation. Br J Clin Pharmacol. 1982;14(3):391–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Gerasimov AM, Toporova SM, Furtseva LN, Berezhnoy AP, Vilensky EV, Alekseeva RI. The role of lysosomes in the pathogenesis of unicameral bone cysts. Clin Orthop Relat Res. 1991;266:53–63.

    Google Scholar 

  19. Komiya S, Inoue A. Development of a solitary bone cyst—a report of a case suggesting its pathogenesis. Arch Orthop Trauma Surg. 2000;120(7–8):455–7.

    Article  CAS  PubMed  Google Scholar 

  20. Komiya S, Tsuzuki K, Mangham DC, Sugiyama M, Inoue A. Oxygen scavengers in simple bone cysts. Clin Orthop Relat Res. 1994;308:199–206.

    Google Scholar 

  21. Neer CS 2nd, Francis KC, Marcove RC, Terz J, Carbonara PN. Treatment of unicameral bone cyst. A follow-up study of one hundred seventy-five cases. J Bone Joint Surg Am. 1966;48(4):731–45.

    Article  PubMed  Google Scholar 

  22. Wright JG. A randomized clinical trial comparing intralesional bone marrow and steroid injections for simple bone cysts. J Bone Joint Surg Am. 2008;90(4):722.

    Article  PubMed  Google Scholar 

  23. Ahn JI, Park JS. Pathological fractures secondary to unicameral bone cysts. Int Orthop. 1994;18(1):20–2.

    Article  CAS  PubMed  Google Scholar 

  24. Galasko CS. Letter: the fate of simple bone cysts which fracture. Clin Orthop Relat Res. 1974;101:302–4.

    Google Scholar 

  25. Garceau GJ, Gregory CF. Solitary unicameral bone cyst. J Bone Joint Surg Am. 1954;36(A:2):267–80.

    Article  CAS  PubMed  Google Scholar 

  26. Neer CS, Francis KC, Johnston AD, Kiernan HA. Current concepts on the treatment of solitary unicameral bone cyst. Clin Orthop Relat Res. 1973;97:40–51.

    Article  Google Scholar 

  27. Kaelin AJ, MacEwen GD. Unicameral bone cysts. Natural history and the risk of fracture. Int Orthop. 1989;13(4):275–82.

    Article  CAS  PubMed  Google Scholar 

  28. Abdel-Wanis ME, Tsuchiya H. Simple bone cyst is not a single entity: point of view based on a literature review. Med Hypotheses. 2002;58(1):87–91.

    Article  CAS  PubMed  Google Scholar 

  29. Vasconcellos DA, Yandow SM, Grace AM, Moritz BM, Marley LD, Fillman RR. Cyst index: a nonpredictor of simple bone cyst fracture. J Pediatr Orthop. 2007;27(3):307–10.

    Article  PubMed  Google Scholar 

  30. Leong NL, Anderson ME, Gebhardt MC, Snyder BD. Computed tomography-based structural analysis for predicting fracture risk in children with benign skeletal neoplasms: comparison of specificity with that of plain radiographs. J Bone Joint Surg Am. 2010;92(9):1827–33.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Cohen J. Unicameral bone cysts. a current synthesis of reported cases. Orthop Clin North Am. 1977;8(4):715–36.

    CAS  PubMed  Google Scholar 

  32. Haims AH, Desai P, Present D, Beltran J. Epiphyseal extension of a unicameral bone cyst. Skelet Radiol. 1997;26(1):51–4.

    Article  CAS  Google Scholar 

  33. Hashemi-Nejad A, Cole WG. Incomplete healing of simple bone cysts after steroid injections. J Bone Joint Surg Br. 1997;79(5):727–30.

    Article  CAS  PubMed  Google Scholar 

  34. Stanton RP, Abdel-Mota'al MM. Growth arrest resulting from unicameral bone cyst. J Pediatr Orthop. 1998;18(2):198–201.

    CAS  PubMed  Google Scholar 

  35. Tey IK, Mahadev A, Lim KB, Lee EH, Nathan SS. Active unicameral bone cysts in the upper limb are at greater risk of fracture. J Orthop Surg (Hong Kong). 2009;17(2):157–60.

    Article  Google Scholar 

  36. Violas P, Salmeron F, Chapuis M, Sales de Gauzy J, Bracq H, Cahuzac JP. Simple bone cysts of the proximal humerus complicated with growth arrest. Acta Orthop Belg. 2004;70(2):166–70.

    PubMed  Google Scholar 

  37. Cho HS, Seo SH, Park SH, Park JH, Shin DS, Park IH. Minimal invasive surgery for unicameral bone cyst using demineralized bone matrix: a case series. BMC Musculoskelet Disord. 2012;13:134.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Lokiec F, Ezra E, Khermosh O, Wientroub S. Simple bone cysts treated by percutaneous autologous marrow grafting. A preliminary report. J Bone Joint Surg Br. 1996;78(6):934–7.

    Article  CAS  PubMed  Google Scholar 

  39. Lokiec F, Wientroub S. Simple bone cyst: etiology, classification, pathology, and treatment modalities. J Pediatr Orthop B. 1998;7(4):262–73.

    Article  CAS  PubMed  Google Scholar 

  40. Chew FS, Bui-Mansfield LT, MJ K. Musculoskeletal imaging. Philadelphia: Lippincott Williams & Wilkins; 2003.

    Google Scholar 

  41. Reynolds J. The "fallen fragment sign" in the diagnosis of unicameral bone cysts. Radiology. 1969;92(5):949–53.. passim

    Article  CAS  PubMed  Google Scholar 

  42. Alyas F, Tirabosco R, Cannon S, Saifuddin A. Fallen fragment sign in Langerhans' cell histiocytosis. Clin Radiol. 2008;63(1):92–6.

    Article  CAS  PubMed  Google Scholar 

  43. Maas EJ, Craig JG, Swisher PK, Amin MB, Marcus N. Fluid-fluid levels in a simple bone cyst on magnetic resonance imaging. Australas Radiol. 1998;42(3):267–70.

    Article  CAS  PubMed  Google Scholar 

  44. Margau R, Babyn P, Cole W, Smith C, Lee F. MR imaging of simple bone cysts in children: not so simple. Pediatr Radiol. 2000;30(8):551–7.

    Article  CAS  PubMed  Google Scholar 

  45. Sullivan RJ, Meyer JS, Dormans JP, Davidson RS. Diagnosing aneurysmal and unicameral bone cysts with magnetic resonance imaging. Clin Orthop Relat Res. 1999;366:186–90.

    Article  Google Scholar 

  46. Zhao JG, Ding N, Huang WJ, Wang J, Shang J, Zhang P. Interventions for treating simple bone cysts in the long bones of children. Cochrane Database Syst Rev. 2014;9:CD010847.

    Google Scholar 

  47. Scaglietti O, Marchetti PG, Bartolozzi P. The effects of methylprednisolone acetate in the treatment of bone cysts. Results of three years follow-up. J Bone Joint Surg Br. 1979;61-B(2):200–4.

    Article  CAS  PubMed  Google Scholar 

  48. Scaglietti O, Marchetti PG, Bartolozzi P. Final results obtained in the treatment of bone cysts with methylprednisolone acetate (depo-medrol) and a discussion of results achieved in other bone lesions. Clin Orthop Relat Res. 1982;165:33–42.

    Google Scholar 

  49. Campanacci M, Capanna R, Picci P. Unicameral and aneurysmal bone cysts. Clin Orthop Relat Res. 1986;204:25–36.

    Google Scholar 

  50. Campanacci M, De Sessa L, Trentani C. Scaglietti's method for conservative treatment of simple bone cysts with local injections of methylprednisolone acetate. Ital J Orthop Traumatol. 1977;3(1):27–36.

    CAS  PubMed  Google Scholar 

  51. Capanna R, Campanacci DA, Manfrini M. Unicameral and aneurysmal bone cysts. Orthop Clin North Am. 1996;27(3):605–14.

    CAS  PubMed  Google Scholar 

  52. Capanna R, Monte AD, Gitelis S, Campanacci M. The natural history of unicameral bone cyst after steroid injection. Clin Orthop Relat Res. 1982;166:204–11.

    Google Scholar 

  53. Capanna R, Albisinni U, Caroli GC, Campanacci M. Contrast examination as a prognostic factor in the treatment of solitary bone cyst by cortisone injection. Skelet Radiol. 1984;12(2):97–102.

    Article  CAS  Google Scholar 

  54. Carrata A, Garbagna P, Mapelli S, Zucchi V. The treatment of simple bone cysts by topical infiltrations of methylprednisolone acetate: technique and results. Eur J Radiol. 1983;3(1):3–8.

    CAS  PubMed  Google Scholar 

  55. Fernbach SK, Blumenthal DH, Poznanski AK, Dias LS, Tachdjian MO. Radiographic changes in unicameral bone cysts following direct injection of steroids: a report on 14 cases. Radiology. 1981;140(3):689–95.

    Article  CAS  PubMed  Google Scholar 

  56. Goel AR, Kriger J, Bronfman R, Lauf E. Unicameral bone cysts: treatment with methylprednisone acetate injections. J Foot Ankle Surg. 1994;33(1):6–15.

    CAS  PubMed  Google Scholar 

  57. Pavone V, Caff G, Di Silvestri C, Avondo S, Sessa G. Steroid injections in the treatment of humeral unicameral bone cysts: long-term follow-up and review of the literature. Eur J Orthop Surg Traumatol. 2013;24(4):497–503.

    Article  PubMed  Google Scholar 

  58. Thawrani D, Thai CC, Welch RD, Copley L, Johnston CE. Successful treatment of unicameral bone cyst by single percutaneous injection of α-BSM. J Pediatr Orthop. 2009;29(5):511–7.

    Article  PubMed  Google Scholar 

  59. Arazi M, Senaran H, Memik R, Kapicioglu S. Minimally invasive treatment of simple bone cysts with percutaneous autogenous bone marrow injection. Orthopedics. 2005;28(2):108–12.

    PubMed  Google Scholar 

  60. Kose N, Gokturk E, Turgut A, Gunal I, Seber S. Percutaneous autologous bone marrow grafting for simple bone cysts. Bull Hosp Jt Dis. 1999;58(2):105–10.

    CAS  PubMed  Google Scholar 

  61. Yandow SM, Lundeen GA, Scott SM, Coffin C. Autogenic bone marrow injections as a treatment for simple bone cyst. J Pediatr Orthop. 1998;18(5):616–20.

    Article  CAS  PubMed  Google Scholar 

  62. Delloye C, Docquier PL, Cornu O, Poilvache P, Peters M, Woitrin B, Rombouts JJ, De Nayer P. Simple bone cysts treated with aspiration and a single bone marrow injection. Int Orthop. 1998;22(2):134–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Chang CH, Stanton RP, Glutting J. Unicameral bone cysts treated by injection of bone marrow or methylprednisolone. J Bone Joint Surg Br. 2002;84(3):407–12.

    Article  CAS  PubMed  Google Scholar 

  64. Wright JG, Yandow S, Donaldson S, Marley L. A randomized clinical trial comparing intralesional bone marrow and steroid injections for simple bone cysts. J Bone Joint Surg Am. 2008;90(4):722–30.

    Article  PubMed  Google Scholar 

  65. Kadhim M, Thacker M, Kadhim A, Holmes L. Treatment of unicameral bone cyst: systematic review and meta analysis. J Child Orthop. 2014;8(2):171–91.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Shinozaki T, Arita S, Watanabe H, Chigira M. Simple bone cysts treated by multiple drill-holes. 23 cysts followed 2-10 years. Acta Orthop Scand. 1996;67(3):288–90.

    Article  CAS  PubMed  Google Scholar 

  67. Chigira M, Watanabe H, Arita S, Udagawa E. Simple bone cyst--pathophysiology and treatment. Nihon Seikeigeka Gakkai Zasshi. 1983b;57(8):759–66.

    CAS  PubMed  Google Scholar 

  68. Chuo CY, Fu YC, Chien SH, Lin GT, Wang GJ. Management strategy for unicameral bone cyst. Kaohsiung J Med Sci. 2003;19(6):289–95.

    Article  PubMed  Google Scholar 

  69. Santori F, Ghera S, Castelli V. Treatment of solitary bone cysts with intramedullary nailing. Orthopedics. 1988;11(6):873–8.

    CAS  PubMed  Google Scholar 

  70. Tsuchiya H, Abdel-Wanis ME, Uehara K, Tomita K, Takagi Y, Yasutake H. Cannulation of simple bone cysts. J Bone Joint Surg Br. 2002;84(2):245–8.

    Article  CAS  PubMed  Google Scholar 

  71. McKay DW, Nason SS. Treatment of unicameral bone cysts by subtotal resection without grafts. J Bone Joint Surg Am. 1977;59(4):515–9.

    Article  CAS  PubMed  Google Scholar 

  72. Chaves D. Treatment of solitary cysts of the humerus. Treated by diaphyseal resection and bone grafting. Int Orthop. 1980;3(4):253–6.

    Article  CAS  PubMed  Google Scholar 

  73. Sturz H, Zenker H, Buckl H. Total subperiosteal resection treatment of solitary bone cysts of the humerus. Arch Orthop Trauma Surg. 1979;93(3):231–9.

    Article  CAS  PubMed  Google Scholar 

  74. Donaldson S, Wright JG. Recent developments in treatment for simple bone cysts. Curr Opin Pediatr. 2011;23(1):73–7.

    Article  PubMed  Google Scholar 

  75. Bonnel F, Canovas F, Faure P. Treatment of a simple bone cyst of the calcaneus by endoscopic curettage with cancellous bone injection. Acta Orthop Belg. 1999;65(4):528–31.

    CAS  PubMed  Google Scholar 

  76. Otsuka T, Kobayashi M, Sekiya I, Yonezawa M, Kamiyama F, Matsushita Y, Matsui N. A new treatment of aneurysmal bone cyst by endoscopic curettage without bone grafting. Arthroscopy. 2001;17(7):1–10.

    Article  Google Scholar 

  77. Yildirim C, Akmaz I, Sahin O, Keklikci K. Simple calcaneal bone cysts: a pilot study comparing open versus endoscopic curettage and grafting. J Bone Joint Surg Br. 2011;93(12):1626–31.

    Article  CAS  PubMed  Google Scholar 

  78. Yıldırım C, Mahiroğulları M, Kuşkucu M, Akmaz İ, Keklikci K. Treatment of a unicameral bone cyst of calcaneus with endoscopic curettage and percutaneous filling with corticocancellous allograft. J Foot Ankle Surg. 2009;49(1):93–7.

    Article  Google Scholar 

  79. Jaffe HL. Solitary unicameral bone cyst. Arch Surg. 1942;44(6):1004.

    Article  Google Scholar 

  80. Mascard E, Gomez-Brouchet A, Lambot K. Bone cysts: unicameral and aneurysmal bone cyst. Orthop Traumatol Surg Res. 2015;101(1 Suppl):S119–27.

    Article  CAS  PubMed  Google Scholar 

  81. Guseva NV, Jaber O, Tanas MR, Stence AA, Sompallae R, Schade J, Fillman AN, Miller BJ, Bossler AD, Ma D. Anchored multiplex PCR for targeted next-generation sequencing reveals recurrent and novelUSP6fusions and upregulation ofUSP6expression in aneurysmal bone cyst. Genes Chromosomes Cancer. 2016;56(4):266–77.

    Article  PubMed  CAS  Google Scholar 

  82. Lau AW, Pringle LM, Quick L, Riquelme DN, Ye Y, Oliveira AM, Chou MM. TRE17/Ubiquitin-specific protease 6 (USP6) oncogene translocated in aneurysmal bone cyst blocks osteoblastic maturation via an autocrine mechanism involving bone morphogenetic protein dysregulation. J Biol Chem. 2010;285(47):37111–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Leithner A, Lang S, Windhager R, Leithner K, Karlic H, Kotz R, Haas OA. Expression of insulin-like growth factor-I (IGF-I) in aneurysmal bone cyst. Mod Pathol. 2001;14(11):1100–4.

    Article  CAS  PubMed  Google Scholar 

  84. Oliveira AM, Hsi BL, Weremowicz S, Rosenberg AE, Dal Cin P, Joseph N, Bridge JA, Perez-Atayde AR, Fletcher JA. USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst. Cancer Res. 2004;64(6):1920–3.

    Article  CAS  PubMed  Google Scholar 

  85. Panoutsakopoulos G, Pandis N, Kyriazoglou I, Gustafson P, Mertens F, Mandahl N. Recurrent t(16;17)(q22;p13) in aneurysmal bone cysts. Genes Chromosomes Cancer. 1999;26(3):265–6.

    Article  CAS  PubMed  Google Scholar 

  86. Toescu SM, Alalade AF, Steele L, Bhargava D, Hunter R. Frontal skull osteoblastoma with aneurysmal bone cyst-like changes associated with trauma during pregnancy: a case report. Acta Neurochir. 2017;159(2):393–6.

    Article  PubMed  Google Scholar 

  87. Kransdorf MJ, Sweet DE. Aneurysmal bone cyst: concept, controversy, clinical presentation, and imaging. AJR Am J Roentgenol. 1995;164(3):573–80.

    Article  CAS  PubMed  Google Scholar 

  88. Nielsen GP, Fletcher JA, Oliveira AM. Aneurysmal bone cyst. In: Fletcher BJA, Hogendoorn PCW, Mertens F, editors. WHO classification of tumours of soft tissue and bone. Lyon: Elsevier Science; 2013. p. 348–9.

    Google Scholar 

  89. Gardner ROE, Summers GR, Hopyan S. Chpater 12: Tumours. postgraduate pediatric orthopaedics: the candidate's guide to the FRCS (Tr and Orth) examination. Cambridge: Cambridge University Press; 2014.

    Google Scholar 

  90. Campanacci M. Aneurysmal bone cyst. Padova: Piccin; 1999.

    Book  Google Scholar 

  91. Cottalorda J, Bourelle S. Modern concepts of primary aneurysmal bone cyst. Arch Orthop Trauma Surg. 2006;127(2):105–14.

    Article  PubMed  Google Scholar 

  92. Cottalorda J, Kohler R, Sales de Gauzy J, Chotel F, Mazda K, Lefort G, Louahem D, Bourelle S, Dimeglio A. Epidemiology of aneurysmal bone cyst in children: a multicenter study and literature review. J Pediatr Orthop B. 2004;13(6):389–94.

    Article  PubMed  Google Scholar 

  93. Murphey MD, wan Jaovisidha S, Temple HT, Gannon FH, Jelinek JS, Malawer MM. Telangiectatic osteosarcoma: radiologic-pathologic comparison. Radiology. 2003;229(2):545–53.

    Article  PubMed  Google Scholar 

  94. Creager AJ, Madden CR, Bergman S, Geisinger KR. Aneurysmal bone cyst: fine-needle aspiration findings in 23 patients with clinical and radiologic correlation. Am J Clin Pathol. 2007;128(5):740–5.

    Article  PubMed  Google Scholar 

  95. Layfield LJ, Armstrong K, Zaleski S, Eckardt J. Diagnostic accuracy and clinical utility of fine-needle aspiration cytology in the diagnosis of clinically primary bone lesions. Diagn Cytopathol. 1993;9(2):168–73.

    Article  CAS  PubMed  Google Scholar 

  96. Rapp TB, Ward JP, Alaia MJ. Aneurysmal bone cyst. J Am Acad Orthop Surg. 2012;20(4):233–41.

    Article  PubMed  Google Scholar 

  97. Biesecker JL, Marcove RC, Huvos AG, Mike V. Aneurysmal bone cysts. A clinicopathologic study of 66 cases. Cancer. 1970;26(3):615–25.

    Article  CAS  PubMed  Google Scholar 

  98. Dormans JP, Hanna BG, Johnston DR, Khurana JS. Surgical treatment and recurrence rate of aneurysmal bone cysts in children. Clin Orthop Relat Res. 2004;421:205–11.

    Article  Google Scholar 

  99. Gibbs CP Jr, Hefele MC, Peabody TD, Montag AG, Aithal V, Simon MA. Aneurysmal bone cyst of the extremities. Factors related to local recurrence after curettage with a high-speed burr. J Bone Joint Surg Am. 1999;81(12):1671–8.

    Article  PubMed  Google Scholar 

  100. Nakatsuka A, Yamakado K, Maeda M, Yasuda M, Akeboshi M, Takaki H, Hamada A, Takeda K. Radiofrequency ablation combined with bone cement injection for the treatment of bone malignancies. J Vasc Interv Radiol. 2004;15(7):707–12.

    Article  PubMed  Google Scholar 

  101. Wallace MT, Henshaw RM. Results of cement versus bone graft reconstruction after intralesional curettage of bone tumors in the skeletally immature patient. J Pediatr Orthop. 2014;34(1):92–100.

    Article  PubMed  Google Scholar 

  102. Mankin HJ, Hornicek FJ, Ortiz-Cruz E, Villafuerte J, Gebhardt MC. Aneurysmal bone cyst: a review of 150 patients. J Clin Oncol. 2005;23(27):6756–62.

    Article  PubMed  Google Scholar 

  103. Ozaki T, Hillmann A, Lindner N, Winkelmann W. Cementation of primary aneurysmal bone cysts. Clin Orthop Relat Res. 1997;337:240–8.

    Article  Google Scholar 

  104. Herold N, Houshian S, Riegels-Nielsen P. A prospective comparison of wedge matrix resection with nail matrix phenolization for the treatment of ingrown toenail. J Foot Ankle Surg. 2001;40(6):390–5.

    Article  CAS  PubMed  Google Scholar 

  105. Misiak P, Terlecki A, Rzepkowska-Misiak B, Wcislo S, Brocki M. Comparison of effectiveness of electrocautery and phenol application in partial matricectomy after partial nail extraction in the treatment of ingrown nails. Pol Przegl Chir. 2014;86(2):89–93.

    PubMed  Google Scholar 

  106. Zaraa I, Dorbani I, Hawilo A, Mokni M, Ben Osman A. Segmental phenolization for the treatment of ingrown toenails: technique report, follow up of 146 patients, and review of the literature. Dermatol Online J. 2013;19(6):18560.

    PubMed  Google Scholar 

  107. Capanna R, Sudanese A, Baldini N, Campanacci M. Phenol as an adjuvant in the control of local recurrence of benign neoplasms of bone treated by curettage. Ital J Orthop Traumatol. 1985;11(3):381–8.

    CAS  PubMed  Google Scholar 

  108. Bitzan P, Windhager R, Lang S, Richling B, Kotz R. Incidence of recurrence of aneurysmal bone cysts following surgical treatment and adjuvant therapy with phenol. Z Orthop Ihre Grenzgeb. 1995;133(5):422–8.

    Article  CAS  PubMed  Google Scholar 

  109. Kececi B, Kucuk L, Isayev A, Sabah D. Effect of adjuvant therapies on recurrence in aneurysmal bone cysts. Acta Orthop Traumatol Turc. 2014;48(5):500–6.

    Article  PubMed  Google Scholar 

  110. Marcove RC, Sheth DS, Takemoto S, Healey JH. The treatment of aneurysmal bone cyst. Clin Orthop Relat Res. 1995;311:157–63.

    Google Scholar 

  111. Marcove RC, Weis LD, Vaghaiwalla MR, Pearson R, Huvos AG. Cryosurgery in the treatment of giant cell tumors of bone. A report of 52 consecutive cases. Cancer. 1978;41(3):957–69.

    Article  CAS  PubMed  Google Scholar 

  112. Peeters SP, Van der Geest IC, de Rooy JW, Veth RP, Schreuder HW. Aneurysmal bone cyst: the role of cryosurgery as local adjuvant treatment. J Surg Oncol. 2009;100(8):719–24.

    Article  CAS  PubMed  Google Scholar 

  113. Schreuder HW, Veth RP, Pruszczynski M, Lemmens JA, Koops HS, Molenaar WM. Aneurysmal bone cysts treated by curettage, cryotherapy and bone grafting. J Bone Joint Surg Br. 1997;79(1):20–5.

    Article  CAS  PubMed  Google Scholar 

  114. Ben-Soussan E, Antonietti M, Savoye G, Herve S, Ducrotte P, Lerebours E. Argon plasma coagulation in the treatment of hemorrhagic radiation proctitis is efficient but requires a perfect colonic cleansing to be safe. Eur J Gastroenterol Hepatol. 2004;16(12):1315–8.

    Article  CAS  PubMed  Google Scholar 

  115. Cummings JE, Smith RA, Heck RK Jr. Argon beam coagulation as adjuvant treatment after curettage of aneurysmal bone cysts: a preliminary study. Clin Orthop Relat Res. 2010;468(1):231–7.

    Article  PubMed  Google Scholar 

  116. Steffner RJ, Liao C, Stacy G, Atanda A, Attar S, Avedian R, Peabody TD. Factors associated with recurrence of primary aneurysmal bone cysts: is argon beam coagulation an effective adjuvant treatment? J Bone Joint Surg Am. 2011;93(21):e1221–9.

    Article  PubMed  Google Scholar 

  117. Rossi G, Rimondi E, Bartalena T, Gerardi A, Alberghini M, Staals EL, Errani C, Bianchi G, Toscano A, Mercuri M, Vanel D. Selective arterial embolization of 36 aneurysmal bone cysts of the skeleton with N-2-butyl cyanoacrylate. Skelet Radiol. 2010;39(2):161–7.

    Article  Google Scholar 

  118. Flont P, Kolacinska-Flont M, Niedzielski K. A comparison of cyst wall curettage and en bloc excision in the treatment of aneurysmal bone cysts. World J Surg Oncol. 2013;11(1):109.

    Article  PubMed  PubMed Central  Google Scholar 

  119. Papagelopoulos PJ, Currier BL, Shaughnessy WJ, Sim FH, Ebersold MJ, Bond JR, Unni KK. Aneurysmal bone cyst of the spine. Spine (Phila Pa 1976). 1998;23(5):621–8.

    Article  CAS  Google Scholar 

  120. Reddy KI, Sinnaeve F, Gaston CL, Grimer RJ, Carter SR. Aneurysmal bone cysts: do simple treatments work? Clin Orthop Relat Res. 2014;472(6):1901–10.

    Article  PubMed  PubMed Central  Google Scholar 

  121. Cakir Y, Hahn KA. Direct action by doxycycline against canine osteosarcoma cell proliferation and collagenase (MMP-1) activity in vitro. In Vivo. 1999;13(4):327–31.

    CAS  PubMed  Google Scholar 

  122. Duivenvoorden WC, Hirte HW, Singh G. Use of tetracycline as an inhibitor of matrix metalloproteinase activity secreted by human bone-metastasizing cancer cells. Invasion Metastasis. 1997;17(6):312–22.

    CAS  PubMed  Google Scholar 

  123. Fife RS, Rougraff BT, Proctor C, Sledge GW Jr. Inhibition of proliferation and induction of apoptosis by doxycycline in cultured human osteosarcoma cells. J Lab Clin Med. 1997;130(5):530–4.

    Article  CAS  PubMed  Google Scholar 

  124. Onoda T, Ono T, Dhar DK, Yamanoi A, Fujii T, Nagasue N. Doxycycline inhibits cell proliferation and invasive potential: combination therapy with cyclooxygenase-2 inhibitor in human colorectal cancer cells. J Lab Clin Med. 2004;143(4):207–16.

    Article  CAS  PubMed  Google Scholar 

  125. Shiels WE, Beebe AC, Mayerson JL. Percutaneous doxycycline treatment of juxtaphyseal aneurysmal bone cysts. J Pediatr Orthop. 2016;36(2):205–12.

    Article  PubMed  Google Scholar 

  126. Shiels WE, Mayerson JL. Percutaneous doxycycline treatment of aneurysmal bone cysts with low recurrence rate: a preliminary report. Clin Orthop Relat Res. 2013;471(8):2675–83.

    Article  PubMed  PubMed Central  Google Scholar 

  127. Drake MT, Clarke BL, Khosla S. Bisphosphonates: mechanism of action and role in clinical practice. Mayo Clin Proc. 2008;83(9):1032–45.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  128. Morgan G, Lipton A. Antitumor effects and anticancer applications of bisphosphonates. Semin Oncol. 2010;37(Suppl 2):S30–40.

    Article  CAS  PubMed  Google Scholar 

  129. Cornelis F, Truchetet ME, Amoretti N, Verdier D, Fournier C, Pillet O, Gille O, Hauger O. Bisphosphonate therapy for unresectable symptomatic benign bone tumors: a long-term prospective study of tolerance and efficacy. Bone. 2014;58:11–6.

    Article  CAS  PubMed  Google Scholar 

  130. Yamagishi T, Kawashima H, Ogose A, Ariizumi T, Sasaki T, Hatano H, Hotta T, Endo N. Receptor-activator of nuclear KappaB ligand expression as a new therapeutic target in primary bone tumors. PLoS One. 2016;11(5):e0154680.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  131. Dubory A, Missenard G, Domont J, Court C. Interest of denosumab for the treatment of giant-cells tumors and aneurysmal bone cysts of the spine. About nine cases. Spine (Phila Pa 1976). 2016;41(11):E654–60.

    Article  Google Scholar 

  132. Pelle DW, Ringler JW, Peacock JD, Kampfschulte K, Scholten DJ 2nd, Davis MM, Mitchell DS, Steensma MR. Targeting receptor-activator of nuclear kappaB ligand in aneurysmal bone cysts: verification of target and therapeutic response. Transl Res. 2014;164(2):139–48.

    Article  CAS  PubMed  Google Scholar 

  133. Skubitz KM, Peltola JC, Santos ER, Cheng EY. Response of aneurysmal bone cyst to denosumab. Spine (Phila Pa 1976). 2015;40(22):E1201–4.

    Article  Google Scholar 

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Deriu, L., Alshryda, S., Wright, J. (2019). Bone Cysts Involving the Hip. In: Alshryda, S., Howard, J., Huntley, J., Schoenecker, J. (eds) The Pediatric and Adolescent Hip. Springer, Cham. https://doi.org/10.1007/978-3-030-12003-0_33

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