Genomic Instability: DNA Repair and Cancer

  • Ana Rita CarlosEmail author
Part of the Learning Materials in Biosciences book series (LMB)


Genomic instability emerges due to accumulation of mutations in the genome, preventing the normal structure and function of the chromosomes. This genomic instability may arise from hereditary mutations or may be associated with DNA damage caused either by endogenous (e.g. replication problems) or exogenous (e.g. radiation) agents. To counter this, cells have evolved various strategies that aim at detecting and repairing DNA damage or at eliminating cells with overt damage. When these strategies fail genomic instability prevails and underlies the hallmark that are key for cancer development.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Instituto Gulbenkian CiênciaOeirasPortugal

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