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Novel Therapies in Paediatric NHL

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Non-Hodgkin's Lymphoma in Childhood and Adolescence

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Abstract

Even though current treatment for paediatric NHL results in excellent outcomes for most children, the burden of therapy and associated morbidities are still significant. In addition, patients with relapsed or refractory disease still have a dismal prognosis with less than 30% of patients achieving a long-term cure. Further intensification of chemotherapy is unlikely to increase cure rates. Novel and targeted therapies that are effective in curing relapsed patients and potentially reduce toxicities in newly diagnosed patients whilst preserving their excellent outcomes are needed. Numerous novel agents approved or in clinical trials for adult NHL are of potential interest for paediatric NHL and will be discussed in this chapter. In addition, the current status of immunotherapy with a focus on chimeric antigen receptor (CAR) and tumour-associated antigen (TAA) T-cells will be reviewed.

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Authors and Affiliations

  1. Department of Paediatric Haematology, Oncology and Palliative Care, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke’s Hospital, Cambridge, UK

    Amos Burke

  2. Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada

    Joerg Krueger

  3. Division of Oncology, Center for Cancer and Blood Disorders, Children’s National Medical Center, The George Washington University School of Medicine, Washington, DC, USA

    Birte Wistinghausen

Authors
  1. Amos Burke
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  2. Joerg Krueger
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  3. Birte Wistinghausen
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Corresponding author

Correspondence to Birte Wistinghausen .

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Editors and Affiliations

  1. University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada

    Oussama Abla

  2. Medical University of Vienna, St. Anna Children’s Hospital, Vienna, Wein, Austria

    Andishe Attarbaschi

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Burke, A., Krueger, J., Wistinghausen, B. (2019). Novel Therapies in Paediatric NHL. In: Abla, O., Attarbaschi, A. (eds) Non-Hodgkin's Lymphoma in Childhood and Adolescence. Springer, Cham. https://doi.org/10.1007/978-3-030-11769-6_26

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  • DOI: https://doi.org/10.1007/978-3-030-11769-6_26

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