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Peripheral T-Cell Lymphoma

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Non-Hodgkin's Lymphoma in Childhood and Adolescence

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Abstract

Non-anaplastic peripheral T-cell lymphoma (PTCL) is a heterogenous group of disorders comprising about 1% of non-Hodgkin lymphoma (NHL) in children and adolescents. Most common subtypes are peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) followed by NK−/T-cell lymphoma (NKTCL), hepatosplenic T-cell lymphoma (HSTCL), and subcutaneous panniculitis-like T-cell lymphoma (SPLTCL). Prognosis of PTCL in children and adolescents is worse than for other childhood NHLs with 5-y EFS around 50% and 5-y OS around 55% but still better than in adults. Survival rates are subtype-specific and best for SPLTCL, intermediate for PTCL-NOS and NKTCL, and worse for HSTCL, requiring subtype-oriented treatment approaches.

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Acknowledgment

We thank Wolfram Klapper, M.D. and Rex K.H. Au-Yeung, M.D. for providing the histological pictures.

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Authors and Affiliations

  1. Department of Pediatric Hematology and Oncology, The Queen Silvia’s Hospital for Children, Göteborg, Sweden

    Karin Mellgren

  2. Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Department of Pediatrics and Adolescent Medicine, University Medical Center Aachen, Aachen, Germany

    Udo Kontny

Authors
  1. Karin Mellgren
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  2. Udo Kontny
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Correspondence to Udo Kontny .

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Editors and Affiliations

  1. University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada

    Oussama Abla

  2. Medical University of Vienna, St. Anna Children’s Hospital, Vienna, Wein, Austria

    Andishe Attarbaschi

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Mellgren, K., Kontny, U. (2019). Peripheral T-Cell Lymphoma. In: Abla, O., Attarbaschi, A. (eds) Non-Hodgkin's Lymphoma in Childhood and Adolescence. Springer, Cham. https://doi.org/10.1007/978-3-030-11769-6_21

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  • DOI: https://doi.org/10.1007/978-3-030-11769-6_21

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-11768-9

  • Online ISBN: 978-3-030-11769-6

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