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Modeling of Cell Membrane Systems

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Biomimetic Lipid Membranes: Fundamentals, Applications, and Commercialization

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Abstract

The mechanisms that take place in or through cell membranes are vitally important for all living organisms. The molecules embedded in or associated to membranes, such as transmembrane proteins, behave dynamically to perform their functions. Although experimental techniques have improved considerably in recent decades, when combined with computational means of modeling, they reveal secrets behind the mechanisms related to membrane systems. The resolution of the structures of membrane proteins has become trivial recently using computerized prediction tools. The worldwide accumulation of structural data in databases enables the application of in-silico methodologies. Simulations, together with the various lipid membrane models, provide information through the dynamic exploration of conformational space. In this chapter, the basics of modeling are discussed, with a focus on molecular dynamic modeling methodology. In addition to modeling, visualization and analysis tools are also mentioned.

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Authors and Affiliations

  1. Acıbadem Mehmet Ali Aydınlar University, Faculty of Engineering, Medical Engineering Department, Istanbul, Turkey

    Tuğba Arzu Özal İldeniz

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  1. Tuğba Arzu Özal İldeniz
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Correspondence to Tuğba Arzu Özal İldeniz .

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  1. Department of Molecular Biology and Genetics, İstanbul Technical University, Istanbul, Turkey

    Fatma N. Kök

  2. Department of Bioengineering, Izmir Institute of Technology, Urla, Izmir, Turkey

    Ahu Arslan Yildiz

  3. School of Medicine, Stanford University, Palo Alto, CA, USA

    Fatih Inci

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Özal İldeniz, T.A. (2019). Modeling of Cell Membrane Systems. In: Kök, F., Arslan Yildiz, A., Inci, F. (eds) Biomimetic Lipid Membranes: Fundamentals, Applications, and Commercialization. Springer, Cham. https://doi.org/10.1007/978-3-030-11596-8_4

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