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Dyslipidemia in Ischemia/Reperfusion Injury

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Bioactive Lipids in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1127))

Abstract

Ischemic heart disease is the main cause of morbidity and mortality in the developed world. Although reperfusion therapies are currently the best treatment for this entity, the restoration of blood flow leads, under certain circumstances, to a form of myocardial damage called reperfusion injury. Several studies have shown that age, sex, smoking, diabetes and dyslipidemia are risk factors for cardiovascular diseases. Among these risk factors, dyslipidemias are present in 40% of patients with ischemic heart disease and represent the clinical factor with the greatest impact on the prognosis of patients with cardiovascular diseases. It is known that during reperfusion the increase of the oxidative stress is perhaps one of the most important mechanisms implicated in cell damage. That is why several researchers have studied protective mechanisms against reperfusion injury, such as the ischemic pre- and post- conditioning, making emphasis mainly on the reduction of oxidative stress. However, few of these efforts have been successfully translated into the clinical setting. The controversial results in regards to the relation between cardioprotective mechanisms and dyslipidemia/hypercholesterolemia are mainly due to the difference among quality, composition and the time of administration of hypercholesterolemic diets, as well as the difference in the species used in each of the studies. Therefore, in order to compare results, it is crucial that all variables that could modify the obtained results are taken into consideration.

The authors Veronica D’Annunzio, Martin Donato, Tamara Zaobornyj, and Ricardo J. Gelpi are Member of the National Council of Scientific and Technological Research of Argentina (CONICET).

The authors Tamara Mazo and Virginia Perez are Fellowship of the National Council of Scientific and Technological Research of Argentina (CONICET).

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Authors and Affiliations

  1. Institute of Cardiovascular Physiopathology and Department of Pathology and Institute of Biochemistry and Molecular Medicine (IBIMOL UBA-CONICET), Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina

    Tamara Mazo, Veronica D’Annunzio, Martin Donato, Virginia Perez & Ricardo J. Gelpi

  2. Institute of Biochemistry and Molecular Medicine (IBIMOL UBA-CONICET) School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

    Tamara Zaobornyj

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  1. Tamara Mazo
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  2. Veronica D’Annunzio
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  3. Martin Donato
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  4. Virginia Perez
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  5. Tamara Zaobornyj
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  6. Ricardo J. Gelpi
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Correspondence to Ricardo J. Gelpi .

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Editors and Affiliations

  1. Departamento de Bioquímica and Centro de Investigaciones Biomédicas (CEINBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay

    Andres Trostchansky

  2. Departamento de Bioquímica and Centro de Investigaciones Biomédicas (CEINBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay

    Homero Rubbo

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Mazo, T., D’Annunzio, V., Donato, M., Perez, V., Zaobornyj, T., Gelpi, R.J. (2019). Dyslipidemia in Ischemia/Reperfusion Injury. In: Trostchansky, A., Rubbo, H. (eds) Bioactive Lipids in Health and Disease. Advances in Experimental Medicine and Biology, vol 1127. Springer, Cham. https://doi.org/10.1007/978-3-030-11488-6_8

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