Skip to main content

Imaging of Musculoskeletal Manifestations Related to Pediatric Hematologic Diseases

  • Chapter
  • First Online:
  • 447 Accesses

Abstract

The vast majority of hematologic diseases (either hemoglobinopathies, coagulopathies, or malignancies) lead to some kind of osteoarticular involvement. Such involvement is often responsible either for the clinical presentation or for some of the most disabling features of these conditions, and it is not uncommon for the radiologist to be the one who first suggests the diagnosis. Awareness of the imaging appearance of the main pediatric hematologic diseases is essential in order to avoid diagnostic errors and allow timely institution of treatment. The following topics cover the imaging features of musculoskeletal manifestations in sickle cell disease, thalassemia, hemophilia, and pediatric hematologic malignancies.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Recommended Reading

  1. Abramson SJ, Price AP. Imaging of pediatric lymphomas. Radiol Clin North Am. 2008;46:313–38.

    Article  Google Scholar 

  2. Aloui N, Nessib N, Jalel C, Ben Chehida F, Zidi A, Bellagha I, et al. Douleurs osseuses fébriles chez l’enfant drépanocytaire: apport de l’IRM. J Radiol. 2005;86:1693–7.

    Article  CAS  Google Scholar 

  3. Babyn P, Doria AS. Radiologic investigation of rheumatic diseases. Rheum Dis Clin North Am. 2007;33:403–40.

    Article  Google Scholar 

  4. Brix N, Hasle H, Rosthøj S, Herlin T. Characteristics of children with acute lymphoblastic leukemia presenting with arthropathy. Clin Rheumatol. 2018;37:2455–63.

    Article  Google Scholar 

  5. Cross S, Vaidya S, Fotiadis N. Hemophilic arthropathy: a review of imaging and staging. Semin Ultrasound CT MR. 2013;34:516–24.

    Article  Google Scholar 

  6. Daldrup-Link HE, Steinbach L. MR imaging of pediatric arthritis. Magn Reson Imaging Clin N Am. 2009;17:451–67.

    Article  Google Scholar 

  7. Doria AS. State-of-the-art imaging techniques for the evaluation of haemophilic arthropathy: present and future. Haemophilia. 2010;16(Suppl 5):107–14.

    Article  Google Scholar 

  8. Ejindu VC, Hine AL, Mashayekhi M, Shorvon PJ, Misra RR. Musculoskeletal manifestations of sickle cell disease. Radiographics. 2007;27:1005–21.

    Article  Google Scholar 

  9. Frank G, Mahoney HM, Eppes SC. Musculoskeletal infections in children. Pediatr Clin North Am. 2005;52:1083–106.

    Article  Google Scholar 

  10. Hughes M, Akram Q, Rees DC, Jones AK. Haemoglobinopathies and the rheumatologist. Rheumatology (Oxford). 2016;55:2109–18.

    Article  Google Scholar 

  11. Karimova EJ, Rai SN, Ingle D, Ralph AC, Deng X, Neel MD, et al. MRI of knee osteonecrosis in children with leukemia and lymphoma: Part 2, clinical and imaging patterns. AJR Am J Roentgenol. 2006;186:477–82.

    Article  Google Scholar 

  12. Kellenberger CJ, Schmugge M, Saurenmann T, Di Gennaro L, Eber SW, Willi UV, et al. Radiographic and MRI features of deferiprone-related arthropathy of the knees in patients with beta-thalassemia. AJR Am J Roentgenol. 2004;183:989–94.

    Article  Google Scholar 

  13. Kerr R. Imaging of musculoskeletal with complications of hemophilia. Semin Musculoskelet Radiol. 2003;7:127–36.

    Article  Google Scholar 

  14. Keshava SN, Gibikote S, Doria AS. Imaging evaluation of hemophilia: musculoskeletal approach. Semin Thromb Hemost. 2015;41:880–93.

    Article  Google Scholar 

  15. Kosaraju V, Harwani A, Partovi S, Bhojwani N, Garg V, Ayyappan S, et al. Imaging of musculoskeletal manifestations in sickle cell disease patients. Br J Radiol. 2017; https://doi.org/10.1259/bjr.20160130.

  16. Maclachlan J, Gough-Palmer A, Hargunani R, Farrant J, Holloway B. Haemophilia imaging: a review. Skeletal Radiol. 2009;38:949–57.

    Article  Google Scholar 

  17. Martinoli C, Bacigalupo L, Forni GL, Balocco M, Garlaschi G, Tagliafico A. Musculoskeletal manifestations of chronic anemias. Semin Musculoskelet Radiol. 2011;15:269–80.

    Article  Google Scholar 

  18. Menon S, Isenberg DA. Rheumatological manifestations of haematological diseases. Ann Rheum Dis. 1995;54:787–95.

    Article  CAS  Google Scholar 

  19. Morais SA, du Preez HE, Akhtar MR, Cross S, Isenberg DA. Musculoskeletal complications of haematological disease. Rheumatology (Oxford). 2016;55:968–81.

    Article  CAS  Google Scholar 

  20. Ng WH, Chu WC, Shing MK, Lam WW, Chik KW, Li CK, et al. Role of imaging in management of hemophilic patients. AJR Am J Roentgenol. 2005;184:1619–23.

    Article  CAS  Google Scholar 

  21. Noureldine MHA, Taher AT, Haydar AA, Berjawi A, Khamashta MA, Uthman I. Rheumatological complications of beta-thalassaemia: an overview. Rheumatology (Oxford). 2018;57:19–27.

    Article  Google Scholar 

  22. Patel CV. The foot and ankle: MR imaging of uniquely pediatric disorders. Magn Reson Imaging Clin N Am. 2009;17:539–47.

    Article  Google Scholar 

  23. Pruthi S, Thapa MM. Infectious and inflammatory disorders. Magn Reson Imaging Clin N Am. 2009;17:423–38.

    Article  Google Scholar 

  24. Sachan AA, Lakhkar BN, Lakhkar BB, Sachan S. Is MRI necessary for skeletal evaluation in sickle cell disease? J Clin Diagn Res. 2015;9:TC08–12.

    PubMed  PubMed Central  Google Scholar 

  25. Seif El Dien HM, Esmail RI, Magdy RE, Lotfy HM. Deferoxamine-induced dysplasia-like skeletal abnormalities at radiography and MRI. Pediatr Radiol. 2013;43:1159–65.

    Article  Google Scholar 

  26. Sharma R, Anand R, Chandra J, Seth A, Pemde H, Singh V. Distal ulnar changes in children with thalassemia and deferiprone related arthropathy. Pediatr Blood Cancer. 2013;60:1957–62.

    Article  Google Scholar 

  27. Soliman M, Daruge P, Dertkigil SSJ, De Avila Fernandes E, Negrao JR, de Aguiar Vilela Mitraud S, et al. Imaging of haemophilic arthropathy in growing joints: pitfalls in ultrasound and MRI. Haemophilia. 2017;23:660–72.

    Article  CAS  Google Scholar 

  28. Vaishya R, Agarwal AK, Edomwonyi EO, Vijay V. Musculoskeletal manifestations of sickle cell disease: a review. Cureus. 2015; https://doi.org/10.7759/cureus.358.

  29. van Vulpen LFD, Holstein K, Martinoli C. Joint disease in haemophilia: pathophysiology, pain and imaging. Haemophilia. 2018;24(Suppl 6):44–9.

    Article  Google Scholar 

  30. Vanderhave KL, Perkins CA, Scannell B, Brighton BK. Orthopaedic manifestations of sickle cell disease. J Am Acad Orthop Surg. 2018;26:94–101.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Viana, S.L., Machado Ribeiro, M.C., Beber Machado, B. (2019). Imaging of Musculoskeletal Manifestations Related to Pediatric Hematologic Diseases. In: Joint Imaging in Childhood and Adolescence. Springer, Cham. https://doi.org/10.1007/978-3-030-11342-1_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-11342-1_9

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-11341-4

  • Online ISBN: 978-3-030-11342-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics