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Imaging of Chronic Recurrent Multifocal Osteomyelitis and Autoinflammatory Bone Disorders

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Joint Imaging in Childhood and Adolescence

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Abstract

Autoinflammatory bone diseases are disorders characterized by chronic osteitis, bone resorption, and abnormal remodeling resulting from aberrant unprovoked activation of the innate immune system. The areas affected by chronic bone inflammation are typically culture-negative, with no apparent pathogen on histopathology. Inflammatory skin lesions are often present, as well as accompanying fever. Chronic recurrent multifocal osteomyelitis (CRMO), SAPHO syndrome, Majeed syndrome, pyoderma gangrenosum and acne (PAPA), deficiency of interleukin-1 receptor antagonist (DIRA), CINCA/NOMID, and cherubism are among the most common autoinflammatory bone disorders in childhood, and CRMO is by far the most studied and well-recognized of them all. This chapter covers the imaging findings of some of these diseases, focusing on CRMO as the prototypical condition of the group.

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Recommended Reading

  1. Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, et al. An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med. 2009;360:2426–37.

    Article  CAS  Google Scholar 

  2. Berkowitz YJ, Greenwood SJ, Cribb G, Davies K, Cassar-Pullicino VN. Complete resolution and remodeling of chronic recurrent multifocal osteomyelitis on MRI and radiographs. Skeletal Radiol. 2018;47:563–8.

    Article  CAS  Google Scholar 

  3. Chen HC, Wuerdeman MF, Chang JH, Nieves-Robbins NM. The role of whole-body magnetic resonance imaging in diagnosing chronic recurrent multifocal osteomyelitis. Radiol Case Rep. 2018;13:485–9.

    Article  Google Scholar 

  4. Costa-Reis P, Sullivan KE. Chronic recurrent multifocal osteomyelitis. J Clin Immunol. 2013;33:1043–56.

    Article  Google Scholar 

  5. Falip C, Alison M, Boutry N, Job-Deslandre C, Cotten A, Azoulay R, et al. Chronic recurrent multifocal osteomyelitis (CRMO): a longitudinal case series review. Pediatr Radiol. 2013;43:355–75.

    Article  Google Scholar 

  6. Greenwood S, Leone A, Cassar-Pullicino VN. SAPHO and recurrent multifocal osteomyelitis. Radiol Clin North Am. 2017;55:1035–53.

    Article  Google Scholar 

  7. Greer MC. Whole-body magnetic resonance imaging: techniques and non-oncologic indications. Pediatr Radiol. 2018;48:1348–63.

    Article  Google Scholar 

  8. Hedrich CM, Hofmann SR, Pablik J, Morbach H, Girschick HJ. Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol Online J. 2013; https://doi.org/10.1186/1546-0096-11-47.

  9. Hill SC, Namde M, Dwyer A, Poznanski A, Canna S, Goldbach-Mansky R. Arthropathy of neonatal onset multisystem inflammatory disease (NOMID/CINCA). Pediatr Radiol. 2007;37:145–52.

    Article  Google Scholar 

  10. Jurik AG, Klicman RF, Simoni P, Robinson P, Teh J. SAPHO and CRMO: the value of imaging. Semin Musculoskelet Radiol. 2018;22:207–24.

    Article  Google Scholar 

  11. Khanna G, Sato TS, Ferguson P. Imaging of chronic recurrent multifocal osteomyelitis. Radiographics. 2009;29:1159–77.

    Article  Google Scholar 

  12. Koplas MC, Simonelli PS, Bauer TW, Joyce MJ, Sundaram M. Your diagnosis? chronic recurrent multifocal osteomyelitis. Orthopedics. 2010;33:218.

    Article  Google Scholar 

  13. Leclair N, Thörmer G, Sorge I, Ritter L, Schuster V, Hirsch FW. Whole-body diffusion-weighted imaging in chronic recurrent multifocal osteomyelitis in children. PLoS One. 2016; https://doi.org/10.1371/journal.pone.0147523.

  14. Mallick A, Chaturvedi A, Muthukumar N. Chronic recurrent multifocal osteomyelitis: a diagnostic dilemma: a case report and review of the literature. JBJS Case Connect. 2016; https://doi.org/10.2106/JBJS.CC.15.00119.

  15. Modesto C. Síndrome CINCA/NOMID. Med Clin (Barc). 2011;136(Suppl 1):10–5.

    Article  Google Scholar 

  16. Morbach H, Hedrich CM, Beer M, Girschick HJ. Autoinflammatory bone disorders. Clin Immunol. 2013;147:185–96.

    Article  CAS  Google Scholar 

  17. Nguyen MT, Borchers A, Selmi C, Naguwa SM, Cheema G, Gershwin ME. The SAPHO syndrome. Semin Arthritis Rheum. 2012;42:254–65.

    Article  Google Scholar 

  18. Queiroz RM, Rocha PHP, Lauar LZ, Costa MJBD, Laguna CB, Oliveira RGG. Chronic recurrent multifocal osteomyelitis exhibiting predominance of periosteal reaction. Rev Assoc Med Bras. 1992;63:303–6.

    Article  Google Scholar 

  19. Roderick MR, Shah R, Rogers V, Finn A, Ramanan AV. Chronic recurrent multifocal osteomyelitis (CRMO) – advancing the diagnosis. Pediatr Rheumatol Online J. 2016; https://doi.org/10.1186/s12969-016-0109-1.

  20. Roderick MR, Sen ES, Ramanan AV. Chronic recurrent multifocal osteomyelitis in children and adults: current understanding and areas for development. Rheumatology (Oxford). 2018;57:41–8.

    Article  Google Scholar 

  21. Rukavina I. SAPHO syndrome: a review. J Child Orthop. 2015;9:19–27.

    Article  Google Scholar 

  22. Sirisha K, Keerthi T, Habibi S, Varaprasad IR, Jyotsna Rani Y, Narendranath L, et al. Chronic recurrent multifocal osteomyelitis complicated by hip subluxation: a case report. Int J Rheum Dis. 2017;20:1800–1.

    Article  Google Scholar 

  23. Stern SM, Ferguson PJ. Autoinflammatory bone diseases. Rheum Dis Clin North Am. 2013;39:735–49.

    Article  Google Scholar 

  24. Surendra G, Shetty U. Chronic recurrent multifocal osteomyelitis: a rare entity. J Med Imaging Radiat Oncol. 2015;59:436–44.

    Article  Google Scholar 

  25. Thacker PG, Binkovitz LA, Thomas KB. Deficiency of interleukin-1-receptor antagonist syndrome: a rare auto-inflammatory condition that mimics multiple classic radiographic findings. Pediatr Radiol. 2012;42:495–8.

    Article  Google Scholar 

  26. Vargas Pérez M, Sevilla Pérez B. SAPHO syndrome in childhood. A case report. Reumatol Clin 2018;14:109–12.

    Google Scholar 

  27. Voit AM, Arnoldi AP, Douis H, Bleisteiner F, Jansson MK, Reiser MF, et al. Whole-body magnetic resonance imaging in chronic recurrent multifocal osteomyelitis: clinical longterm assessment may underestimate activity. J Rheumatol. 2015;42:1455–62.

    Article  Google Scholar 

  28. von Kalle T, Heim N, Hospach T, Langendörfer M, Winkler P, Stuber T. Typical patterns of bone involvement in whole-body MRI of patients with chronic recurrent multifocal osteomyelitis (CRMO). Rofo. 2013;185:655–61.

    Article  Google Scholar 

  29. Zaki FM, Sridharan R, Pei TS, Ibrahim S, Ping TS. NOMID: the radiographic and MRI features and review of literature. J Radiol Case Rep. 2012;6:1–8.

    PubMed  PubMed Central  Google Scholar 

  30. Zhao Y, Ferguson PJ. Chronic nonbacterial osteomyelitis and chronic recurrent multifocal osteomyelitis in children. Pediatr Clin North Am. 2018;65:783–800.

    Article  Google Scholar 

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Authors and Affiliations

  1. Hospital da Criança de Brasília José Alencar, Hospital Ortopédico e Medicina Especializada (HOME) and Diagnóstico Clínica de Imagens Médicas, Brasília, Distrito Federal, Brazil

    Sergio Lopes Viana

  2. Hospital da Criança de Brasília José Alencar, Brasília, Distrito Federal, Brazil

    Maria Custódia Machado Ribeiro

  3. Gastren Clínica Médica e Radiológica (Iúna-ES), Clínica Radiológica Med Imagem, Clínica Radiológica Radial, Santa Casa de Misericórdia and Unimed Sul Capixaba, Cachoeiro de Itapemirim, Espírito Santo, Brazil

    Bruno Beber Machado

Authors
  1. Sergio Lopes Viana
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  2. Maria Custódia Machado Ribeiro
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  3. Bruno Beber Machado
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Viana, S.L., Machado Ribeiro, M.C., Beber Machado, B. (2019). Imaging of Chronic Recurrent Multifocal Osteomyelitis and Autoinflammatory Bone Disorders. In: Joint Imaging in Childhood and Adolescence. Springer, Cham. https://doi.org/10.1007/978-3-030-11342-1_6

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  • DOI: https://doi.org/10.1007/978-3-030-11342-1_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-11341-4

  • Online ISBN: 978-3-030-11342-1

  • eBook Packages: MedicineMedicine (R0)

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