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Clinical Ophthalmic Oncology pp 213–219Cite as

Retinoblastoma: Evolving Therapies

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Abstract

Retinoblastoma is the most common primary malignant cancer of the eye in children arising in the developing retina. Depending on tumour stage, number of tumour foci, localization and size of tumours within the eye, presence of vitreous seeding, metastatic situations, age and health of the child, and the family’s wishes, doctors choose different therapies for retinoblastoma patients. The traditional treatment options include enucleation, cryotherapy, laser photocoagulation, thermotherapy, systemic chemotherapy, radiation therapy, or a combination of these. In recent years, in order to achieve the maximum concentrations of chemotherapy close to the tumour and in the vitreous, intra-arterial chemotherapy, intravitreal chemotherapy and pars plana vitrectomy (PPV) have emerged as potential therapies.

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References

  1. Mendoza PR, Grossniklaus HE. The biology of retinoblastoma. Prog Mol Biol Transl Sci. 2015;134:503–16.

    Article  CAS  Google Scholar 

  2. Shields CL, Shields JA. Retinoblastoma management: advances in enucleation, intravenous chemoreduction, and intra-arterial chemotherapy. Curr Opin Ophthalmol. 2010;21(3):203–12.

    Article  Google Scholar 

  3. Fabian ID, Onadim Z, Karaa E, et al. The management of retinoblastoma. Oncogene. 2018;37(12):1551–60.

    Article  CAS  Google Scholar 

  4. Mallipatna AC, Sutherland JE, Gallie BL, et al. Management and outcome of unilateral retinoblastoma. J AAPOS. 2009;13:546–50.

    Article  Google Scholar 

  5. Stallard HB. Radiotherapy of malignant intraocular neoplasms. Br J Ophthalmol. 1948;32:618–39.

    Article  CAS  Google Scholar 

  6. Moore RF, Stallard HB, Milner JG. Retinal gliomata treated by radon seeds. Br J Ophthalmol. 1931;15:673–96.

    Article  CAS  Google Scholar 

  7. Stallard HB. The treatment of retinoblastoma. Ophthalmologica. 1966;151:214–30.

    Article  CAS  Google Scholar 

  8. Fletcher O, Easton D, Anderson K, et al. Lifetime risks of common cancers among retinoblastoma survivors. J Natl Cancer Inst. 2004;96:357–63.

    Article  Google Scholar 

  9. Kleinerman RA, Tucker MA, Tarone RE, et al. Risk of new cancers after radiotherapy in long-term survivors of retinoblastoma: an extended follow-up. J Clin Oncol. 2005;23:2272–9.

    Article  Google Scholar 

  10. Kingston JE, Hungerford JL, Madreperla SA, et al. Results of combined chemotherapy and radiotherapy for advanced intraocular retinoblastoma. Arch Ophthalmol. 1996;114:1339–43.

    Article  CAS  Google Scholar 

  11. Murphree AL, Villablanca JG, Deegan WF, et al. Chemotherapy plus local treatment in the management of intraocular retinoblastoma. Arch Ophthal- mol. 1996;114:1348–56.

    Article  CAS  Google Scholar 

  12. Shields CL, De Potter P, Himelstein BP, et al. Chemoreduction in the initial management of intraocular retinoblastoma. Arch Ophthalmol. 1996;114:1330–8.

    Article  CAS  Google Scholar 

  13. Gallie BL, Budning A, DeBoer G, et al. Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy. Arch Ophthalmol. 1996;114:1321–8.

    Article  CAS  Google Scholar 

  14. Jehanne M, Lumbroso-Le Rouic L, Savignoni A, et al. Analysis of ototoxicity in young children receiving carboplatin in the context of conservative management of unilateral or bilateral retinoblastoma. Pediatr Blood Cancer. 2009;52:637–43.

    Google Scholar 

  15. Wong JR, Morton LM, Tucker MA, et al. Risk of subsequent malignant neoplasms in long-term hereditary retinoblastoma survivors after chemotherapy and radiotherapy. J Clin Oncol. 2014;32:3284–90.

    Google Scholar 

  16. Draper GJ, Sanders BM, Kingston JE. Second primary neoplasms in patients with retinoblastoma. Br J Cancer. 1986;53:661–71.

    Article  CAS  Google Scholar 

  17. Smith MA, Rubinstein L, Anderson JR, et al. Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxins. J Clin Oncol. 1999;17:569–77.

    Google Scholar 

  18. Gombos DS, Hungerford J, Abramson DH, et al. Secondary acute myelogenous leukemia in patients with retinoblastoma: is chemotherapy a factor? Ophthalmology. 2007;114:1378–83.

    Google Scholar 

  19. Murphree AL. Intraocular retinoblastoma: the case for a new group classification. Ophthalmol Clin N Am. 2005;18:41–53.

    Article  Google Scholar 

  20. Suzuki S, Yamane T, Mohri M, et al. Selective ophthalmic arterial injection therapy for intraocular retinoblastoma: the long-term prognosis. Ophthalmology. 2011;118:2081–7.

    Article  Google Scholar 

  21. Kaneko A, Suzuki S. Eye-preservation treatment of retinoblastoma with vitreous seeding. Jpn J Clin Oncol. 2003;33:601–7.

    Article  Google Scholar 

  22. Abramson DH, Dunkel IJ, Brodie SE, et al. A phase I/II study of direct intra-arterial (ophthalmic artery) chemotherapy with melphalan for intraocular retinoblastoma: initial results. Ophthalmology. 2008;115:1398–404.

    Article  Google Scholar 

  23. Gobin Y, Dunke IJ, Marr BP, et al. Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience. Arch Ophthalmol. 2011;129:732–7.

    Article  Google Scholar 

  24. Shields CL, Bianciotto CG, Jabbour P, et al. Intra-arterial chemotherapy for retinoblastoma: Report no. 1, control of retinal tumors, subretinal seeds, and vitreous seeds. Arch Ophthalmol. 2011;129:1399–406.

    Article  Google Scholar 

  25. Abramson DD, Dunkel IJ, Brodie SE, et al. Bilateral superselective ophthalmic artery chemotherapy for bilateral retinoblastoma: tandem therapy. Arch Ophthalmol. 2010;128:370–2.

    Article  Google Scholar 

  26. Francis J, Gobin Y, Dunkel I, et al. Carboplatin 1/− topotecan ophthalmic artery chemosurgery for intraocular retinoblastoma. PLoS One. 2013;8:e72441.

    Article  CAS  Google Scholar 

  27. Schaiquevich P, Ceciliano A, Millan N, et al. Intra-arterial chemotherapy is more effective than sequential periocular and intravenous chemotherapy as salvage treatment for relapsed retinoblastoma. Pediatr Blood Cancer. 2013;60:766–70.

    Article  CAS  Google Scholar 

  28. Abramson DH, Marr BP, Dunkel IJ, et al. Intra-arterial chemotherapy for retinoblastoma in eyes with vitreous and/or subretinal seeding: 2-year results. Br J Ophthalmol. 2012;96:499–502.

    Article  Google Scholar 

  29. Gobin Y, Dunkel I, Marr BP, et al. Combined, sequential intravenous and intra- arterial chemotherapy (bridge chemotherapy) for young infants with retinoblastoma. PLoS One. 2012;7:e44322.

    Article  CAS  Google Scholar 

  30. De la Huerta I, Seider MI, Hetts SW, et al. Delayed cerebral infarction following intra-arterial chemotherapy for retinoblastoma. JAMA Ophthalmol. 2016 Jun 1;134(6):712–4.

    Article  Google Scholar 

  31. Gobin Y, Rosenstein LM, Marr BP, et al. Radiation exposure during intra-arterial chemotherapy for retinoblastoma. Arch Ophthalmol. 2012;130:403–5.

    Article  Google Scholar 

  32. Vijayakrishnan R, Shields CL, Ramasubramanian A, et al. Irradiation toxic effects during intra-arterial chemotherapy for retinoblastoma: should we be concerned? Arch Ophthalmol. 2010;128:1427–31.

    Article  Google Scholar 

  33. Manjandavida FP, Honavar SG, Reddy VA, et al. Management and outcome of retinoblastoma with vitreous seeds. Ophthalmology. 2014;121:517–24.

    Article  Google Scholar 

  34. Francis JH, Abramson DH, Gaillard MC, et al. The classification of vitreous seeds in retinoblastoma and response to intravitreal melphalan. Ophthalmology. 2015;122:1173–9.

    Google Scholar 

  35. Moulin AP, Gaillard MC, Balmer A, et al. Ultrasound biomicroscopy evaluation of anterior extension in retinoblastoma: a clinicopathological study. Br J Ophthalmol. 2012;96:337–40.

    Article  Google Scholar 

  36. Francis JH, Schaiquevich P, Buitrago E, et al. Local and systemic toxicity of intravitreal melphalan for vitreous seeding in retinoblastoma: a preclinical and clinical study. Ophthalmology. 2014;121:1810–7.

    Article  Google Scholar 

  37. Francis JH, Marr BP, Brodie SE, et al. Anterior ocular toxicity of Intravitreous Melphalan for retinoblastoma. JAMA Ophthalmol. 2015;133:1459–63.

    Article  Google Scholar 

  38. Zhao J, Li S, Shi J, et al. Clinical presentation and group classification of newly diagnosed intraocular retinoblastoma in China. Br J Ophthalmol. 2011;95(10):1372–5.

    Article  Google Scholar 

  39. Abramson DH, Beaverson KL, Chang ST, et al. Outcome following initial external beam radiotherapy in patients with Reese-Ellsworth group Vb retinoblastoma. Arch Ophthalmol. 2004;122:1316–23.

    Article  Google Scholar 

  40. Seregard S, Singh AD. Retinoblastoma: direct chemotherapeutic drug delivery into the vitreous cavity. Br J Ophthalmol. 2012;96:473–4.

    Article  Google Scholar 

  41. Honavar SG, Shields CL, Shields JA, et al. Intraocular surgery after treatment of retinoblastoma. Arch Ophthalmol. 2001;119:1613–21.

    Article  CAS  Google Scholar 

  42. Moshfeghi DM, Wilson MW, Grizzard S, et al. Intraocular surgery after treatment of germline retinoblastoma. Arch Ophthalmol. 2005;123:1008–12.

    Article  Google Scholar 

  43. Shimoda Y, Hamano R, Ishihara K, et al. Effects of intraocular irrigation with melphalan on rabbit retinas during vitrectomy. Graefes Arch Clin Exp Ophthalmol. 2008;246:501–8.

    Article  CAS  Google Scholar 

  44. Ohshima K, Kaneko T, Takagi S, et al. Clinicopathological investigation of a retinoblastoma eye enucleated after vitreous surgery with melphalan perfusion. Jpn J Ophthalmol. 2009;53:186–8.

    Article  Google Scholar 

  45. Yarovoy AA, Ushakova TL, Gorshkov IM, et al. Intraocular surgery with melphalan irrigation for vitreous hemorrhage in an only eye with retinoblastoma. Eur J Ophthalmol. 2015 Dec 1;26(1):e17–9.

    Google Scholar 

  46. Warden SM, Mukai S. Pars plana vitrectomy in eyes treated for retinoblastoma. Retina. 2006 Sep;26(7 Suppl):S53–6.

    Article  Google Scholar 

  47. Ji X-D, Lu S-L, Zhao P-Q. Vitrectomy for localized vitreous seeds of retinoblastoma in an only eye. Chinese Med J. 2013;126:2589–90.

    Google Scholar 

  48. Zhao J, Li Q, Wu S, et al. Pars Plana vitrectomy and Endoresection of refractory intraocular retinoblastoma. Ophthalmology. 2018 Feb;125(2):320–2.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China

    Junyang Zhao & Honggai Yan

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  1. Junyang Zhao
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  2. Honggai Yan
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Editor information

Editors and Affiliations

  1. Associate Professor of Ophthalmology, Children’s Hospital Los Angeles, The USC Roski Eye Institute Keck School of Medicine, Los Angeles, CA, USA

    Jesse L. Berry

  2. Children’s Hospital Los Angeles, The USC Roski Eye Institute, Keck School of Medicine, Los Angeles, CA, USA

    Jonathan W. Kim

  3. University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK

    Bertil E. Damato

  4. Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA

    Arun D. Singh

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Zhao, J., Yan, H. (2019). Retinoblastoma: Evolving Therapies. In: Berry, J., Kim, J., Damato, B., Singh, A. (eds) Clinical Ophthalmic Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-11123-6_18

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  • DOI: https://doi.org/10.1007/978-3-030-11123-6_18

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-11122-9

  • Online ISBN: 978-3-030-11123-6

  • eBook Packages: MedicineMedicine (R0)

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