Heterogeneity of Human Mesenchymal Stromal/Stem Cells

  • Weiqiang Wang
  • Zhong Chao Han
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1123)


Increasing evidence has shown that mesenchymal stem cells (MSCs) isolated from body tissues are heterogeneous while being examined in vitro and in vivo. Besides some common characteristics, MSCs derived from different tissues exhibit unique biological properties. In addition, the therapeutic effects of MSCs may vary widely due to their heterogeneity and the technical differences in large-scale ex vivo expansion. In this chapter, the heterogeneity of MSCs will be discussed in three levels: the individual donors, the tissue sources, and the cell surface markers.


Mesenchymal stem cells Heterogeneity Surface markers Biological property Cell therapy Subpopulation Regenerative property Immunomodulatory ability Individual donor Tissue source 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Weiqiang Wang
    • 1
    • 2
    • 3
  • Zhong Chao Han
    • 1
    • 2
    • 3
    • 4
  1. 1.National Engineering Research Center of Cell ProductsTianjin AmCellGene Engineering Co., LtdTianjinChina
  2. 2.Tianjin Institute of Health & Stem Cells, Health & Biotech Co., LtdTianjinChina
  3. 3.Jiangxi Provincial Engineering Technology Research Center of Stem CellJiangxiChina
  4. 4.Beijing Institute of Stem Cells, Health & Biotech Co., Ltd.BeijingChina

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