Pericytes in the Gut

  • Marta Ramirez
  • Nuria Pell
  • Marc Mejias
  • Mercedes FernandezEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1122)


This review chapter describes the current knowledge about the nature of pericytes in the gut, their interaction with endothelial cells in blood vessels, and their pathophysiological functions in the setting of chronic liver disease. In particular, it focuses on the role of these vascular cell types and related molecular signaling pathways in pathological angiogenesis associated with liver disease and in the establishment of the gut-vascular barrier and the potential implications in liver disease through the gut-liver axis.


Chronic liver disease Pathological angiogenesis Gut-vascular barrier Portosystemic collateral vessels Mesenteric vascular bed Intestinal circulation 


Grant Support

This is supported by grants from the Spanish Ministry of Economy and Competitiveness (MINECO; SAF2014–55473-R and BES2015–071399); the Spanish Ministry of Science, Innovation and Universities (SAF2017–87988-R); the European Union FEDER funds; the Spanish Association Against Cancer (AECC); the Worldwide Cancer Research Foundation; and the CERCA Programme (Generalitat de Catalunya, Spain). CIBERehd is an initiative from the Instituto de Salud Carlos III.

Disclosures All authors declare no competing financial interests.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Marta Ramirez
    • 1
  • Nuria Pell
    • 1
  • Marc Mejias
    • 1
    • 2
  • Mercedes Fernandez
    • 1
    • 2
    Email author
  1. 1.Angiogenesis in Liver Disease Research GroupIDIBAPS Biomedical Research Institute, Hospital Clinic, University of BarcelonaBarcelonaSpain
  2. 2.Biomedical Research Networking Center on Hepatic and Digestive Disease (CIBEREHD)Spanish National Institute of HealthBarcelonaSpain

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