Oral Signs of Endocrine and Metabolic Diseases

  • Jaisri R. ThoppayEmail author
  • Thomas P. Sollecito
  • Scott S. De Rossi


The endocrine system is complex but vital in maintaining homeostasis of multiple organ systems via hormones. These hormones are released from cells that circulate and affect distant organs. Endocrine dysfunction involving alteration in hormone levels has significant disease manifestations that may involve single or multiple systems and can affect the orofacial region. Therefore, patients with endocrine disorders may have an array of different symptoms and clinical manifestations. Various endocrine and metabolic disorders may manifest orally as soft tissue or hard tissue changes or both.


Oral lesions Macroglossia Taurodontism Amyloidosis Osteitis fibrosa cystica Hypercementosis Porphryia cutanea tarda 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Jaisri R. Thoppay
    • 1
    Email author
  • Thomas P. Sollecito
    • 2
  • Scott S. De Rossi
    • 3
  1. 1.Department of Oral and Maxillofacial Surgery, VCU School of Dentistry at VCU Medical CenterVirginia Commonwealth UniversityRichmondUSA
  2. 2.The Robert Schattner CenterUniversity of Pennsylvania School of Dental MedicinePhiladelphiaUSA
  3. 3.Department of Oral MedicineAugusta University Dental College of GeorgiaAugustaUSA

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