Abstract
Hematopoietic and mesenchymal stem cells are multipotent cells which have the ability to re-establish the bone marrow and immune systems. They can be derived from a multitude of sources, and the choice of using a specific stem cell source for a specific patient depends on the patient’s underlying disease state and comorbidities. Stem cells can be harvested from the patient’s own hemato-immune system, i.e., AUTOLOGOUS collection, or from another person (a donor), i.e., ALLOGENIC sources. The cells can be harvested through an APHERESIS (peripheral stem cell collection), from the placenta and CORD BLOOD or from the donor’s bone marrow. Unlike hematopoietic stem cells, mesenchymal stem cells are not specific for a patient. They are undifferentiated cells with the capacity of self-renewal and the ability to undergo multilineage differentiation which can be obtained from a multitude of sources.
Final manuscript submitted on November 11, 2017.
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Wiedl, C., Godder, K. (2019). The Pharmacology of Stem Cell Transplant for Autoimmune Disease. In: Parnham, M., Nijkamp, F., Rossi, A. (eds) Nijkamp and Parnham's Principles of Immunopharmacology. Springer, Cham. https://doi.org/10.1007/978-3-030-10811-3_36
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DOI: https://doi.org/10.1007/978-3-030-10811-3_36
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