Abstract
T cell-mediated immunity is an adaptive process of developing antigen (Ag)-specific T LYMPHOCYTES to eliminate viral, bacterial, or parasitic infections or malignant cells. T cell-mediated immunity can also involve aberrant recognition of self-antigens leading to autoimmune inflammatory diseases. Ag specificity of T LYMPHOCYTES is based on recognition through the TcR of unique antigenic peptides presented by MHC molecules on antigen-presenting cells. T cell-mediated immunity is the central element of the adaptive immune system and includes a primary response by naïve T cells, effector functions by activated T cells, and persistence of Ag-specific memory T cells. T cell-mediated immunity is part of a complex and coordinated immune response that includes other effector cells such as MACROPHAGES, NATURAL KILLER CELLS, MAST CELLS, BASOPHILS, EOSINOPHILS, and NEUTROPHILS.
Final manuscript submitted on October 27, 2015.
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We are indebted to Sergei G. Apasov and Michail V. Sitkovsky who created the basis of this chapter and contributed to the early editions of this book.
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Broere, F., van Eden, W. (2019). T Cell Subsets and T Cell-Mediated Immunity. In: Parnham, M., Nijkamp, F., Rossi, A. (eds) Nijkamp and Parnham's Principles of Immunopharmacology. Springer, Cham. https://doi.org/10.1007/978-3-030-10811-3_3
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