Skip to main content

Immune Response in Human Pathology: Hypersensitivity and Autoimmunity

  • Chapter
  • First Online:
Nijkamp and Parnham's Principles of Immunopharmacology
  • 1026 Accesses

Abstract

The primary role of the immune system is to maintain the body’s homeostasis by discriminating self from nonself through a complex network of specialized cells and molecules tuned to ensure coordinated immune responses under the control of mechanisms with either compensatory or opposing outcome.

Final manuscript submitted on June 21, 2018.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Selected Readings

  • Adkinson NF, Bochner BS, Burks W, Busse WW, Holgate ST, Lemanske RF, O’Behir RE. Middleton’s allergy: principles and practice. 8th ed. Philadelphia, PA: Elsevier Saunders; 2014.

    Google Scholar 

  • Baldo BA, Pham NH. Drug allergy: clinical aspects, diagnosis, mechanisms, structure-activity relationships. Berlin: Springer; 2013.

    Book  Google Scholar 

  • Shoenfeld Y, Meroni PL, Gershwin ME. Autoantibodies. 3rd ed. Amsterdam: Elsevier; 2014.

    Google Scholar 

References

  1. Pallardy M, Bechara R. Chemical or drug hypersensitivity: is the immune system clearing the danger? Toxicol Sci. 2017;158:14–22.

    Article  CAS  PubMed  Google Scholar 

  2. Baldo BA, Pham NH. Drug allergy: clinical aspects, diagnosis, mechanisms, structure-activity relationships. Berlin: Springer; 2013. 447 p.

    Book  Google Scholar 

  3. Thong BY, Tan TC. Epidemiology and risk factors for drug allergy. Br J Clin Pharmacol. 2011;71:684–700.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Kuruvilla M, Khan DA. Anaphylaxis to drugs. Immunol Allergy Clin North Am. 2015;35:303–19.

    Article  PubMed  Google Scholar 

  5. Stone SF, Phillips EJ, Wiese MD, Heddle RJ, Brown SG. Immediate-type hypersensitivity drug reactions. Br J Clin Pharmacol. 2014;78:1–13.

    Article  CAS  PubMed  Google Scholar 

  6. Tejedor-Alonso MA, Moro-Moro M, Múgica-García MV. Epidemiology of anaphylaxis. Clin Exp Allergy. 2015;45:1027–39.

    Article  CAS  PubMed  Google Scholar 

  7. Song TT, Lieberman P. Epinephrine in anaphylaxis: doubt no more. Curr Opin Allergy Clin Immunol. 2015;15:323–8.

    Article  CAS  PubMed  Google Scholar 

  8. Marzano AV, Borghi A, Cugno M. Adverse drug reactions and organ damage: the skin. Eur J Intern Med. 2016;28:17–24.

    Article  CAS  PubMed  Google Scholar 

  9. Zalewska-Janowska A, Spiewak R, Kowalski ML. Cutaneous manifestation of drug allergy and hypersensitivity. Immunol Allergy Clin North Am. 2017;37:165–81.

    Article  PubMed  Google Scholar 

  10. Hausmann O, Schnyder B, Pichler WJ. Drug hypersensitivity reactions involving skin. Handb Exp Pharmacol. 2010;196:29–55.

    Article  CAS  Google Scholar 

  11. Schrijvers R, Gilissen L, Chiriac AM, Demoly P. Pathogenesis and diagnosis of delayed-type drug hypersensitivity reactions, from bedside to bench and back. Clin Transl Allergy. 2015;5:31.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. Pavlos R, Mallal S, Ostrov D, Buus S, Metushi I, Peters B, Phillips E. T cell-mediated hypersensitivity reactions to drugs. Annu Rev Med. 2015;66:439–54.

    Article  CAS  PubMed  Google Scholar 

  13. Harr T, French LE. Stevens-Johnson syndrome and toxic epidermal necrolysis. Chem Immunol Allergy. 2012;97:149–66.

    Article  PubMed  Google Scholar 

  14. Dodiuk-Gad RP, Chung WH, Valeyrie-Allanore L, Shear NH. Stevens-Johnson syndrome and toxic epidermal necrolysis: an update. Am J Clin Dermatol. 2015;16:475–93.

    Article  PubMed  Google Scholar 

  15. Spriet S, Banks TA. Drug reaction with eosinophilia and systemic symptoms syndrome. Allergy Asthma Proc. 2015;36:501–5.

    Article  CAS  PubMed  Google Scholar 

  16. Shiohara T, Kano Y. Drug reaction with eosinophilia and systemic symptoms (DRESS): incidence, pathogenesis and management. Expert Opin Drug Saf. 2017;16:139–47.

    CAS  PubMed  Google Scholar 

  17. Avancini J, Maragno L, Santi CG, Criado PR. Drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome: clinical features of 27 patients. Clin Exp Dermatol. 2015;40:851–9.

    Article  CAS  PubMed  Google Scholar 

  18. Kostner L, Anzengruber F, Guillod C, Recher M, Schmid-Grendelmeier P, Navarini AA. Allergic contact dermatitis. Immunol Allergy Clin North Am. 2017;37:141–52.

    Article  PubMed  Google Scholar 

  19. Andrès E, Federici L, Weitten T, Vogel T, Alt M. Recognition and management of drug-induced blood cytopenias: the example of drug-induced acute neutropenia and agranulocytosis. Expert Opin Drug Saf. 2008;7:481–9.

    Article  PubMed  Google Scholar 

  20. Arndt PA. Drug-induced immune hemolytic anemia: the last 30 years of changes. Immunohematology. 2014;30:44–54.

    PubMed  Google Scholar 

  21. Garratty G. Immune hemolytic anemia caused by drugs. Expert Opin Drug Saf. 2012;11:635–42.

    Article  CAS  PubMed  Google Scholar 

  22. Arnold DM, Nazi I, Warkentin TE, Smith JW, Toltl LJ, George JN, Kelton JG. Approach to the diagnosis and management of drug-induced immune thrombocytopenia. Transfus Med Rev. 2013;27:137–45.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Chong BH, Choi PY, Khachigian L, Perdomo J. Drug-induced immune thrombocytopenia. Hematol Oncol Clin North Am. 2013;27:521–40.

    Article  PubMed  Google Scholar 

  24. Dasararaju R, Singh N, Mehta A. Heparin induced thrombocytopenia: review. Expert Rev Hematol. 2013;6:419–28.

    Article  CAS  PubMed  Google Scholar 

  25. Onakpoya IJ, Heneghan CJ, Aronson JK. Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic review of the world literature. BMC Med. 2016;14:10.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Senior JR. Evolution of the Food and Drug Administration approach to liver safety assessment for new drugs: current status and challenges. Drug Saf. 2014;37(Suppl 1):S9–17.

    Article  PubMed  CAS  Google Scholar 

  27. Mosedale M, Watkins PB. Drug-induced liver injury: advances in mechanistic understanding that will inform risk management. Clin Pharmacol Ther. 2017;101:469–80.

    Article  CAS  PubMed  Google Scholar 

  28. Ju C, Reilly T. Role of immune reactions in drug-induced liver injury (DILI). Drug Metab Rev. 2012;44:107–15.

    Article  CAS  PubMed  Google Scholar 

  29. Roth AD, Lee MY. Idiosyncratic drug-induced liver injury (IDILI): potential mechanisms and predictive assays. Biomed Res Int. 2017;2017:9176937.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  30. Krishnan N, Perazella MA. Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment. Iran J Kidney Dis. 2015;9:3–13.

    PubMed  Google Scholar 

  31. Nast CC. Medication-induced interstitial nephritis in the 21st century. Adv Chronic Kidney Dis. 2017;24:72–9.

    Article  PubMed  Google Scholar 

  32. Matsuno O. Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches. Respir Res. 2012;13:39.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Brockow K, Przybilla B, Aberer W, Bircher AJ, et al. Guideline for the diagnosis of drug hypersensitivity reactions. Allergo J Int. 2015;24:94–105.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Schnyder B, Brockow K. Pathogenesis of drug allergy - current concepts and recent insights. Clin Exp Allergy. 2015;45:1376–83.

    Article  CAS  PubMed  Google Scholar 

  35. Chirmule N, Jawa V, Meibohm B. Immunogenicity to therapeutic proteins: impact on PK/PD and efficacy. AAPS J. 2012;14:296–302.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Vultaggio A, Nencini F, Pratesi S, Petroni G, Maggi E, Matucci A. Manifestations of antidrug antibodies response: hypersensitivity and infusion reactions. J Interferon Cytokine Res. 2014;34:946–52.

    Article  CAS  PubMed  Google Scholar 

  37. Ratanji KD, Derrick JP, Dearman RJ, Kimber I. Immunogenicity of therapeutic proteins: influence of aggregation. J Immunotoxicol. 2014;11:99–109.

    Article  CAS  PubMed  Google Scholar 

  38. Liu L. Antibody glycosylation and its impact on the pharmacokinetics and pharmacodynamics of monoclonal antibodies and Fc-fusion proteins. J Pharm Sci. 2015;104:1866–84.

    Article  CAS  PubMed  Google Scholar 

  39. Hamuro L, Kijanka G, Kinderman F, Kropshofer H, Bu DX, Zepeda M, Jawa V. Perspectives on subcutaneous route of administration as an immunogenicity risk factor for therapeutic proteins. J Pharm Sci. 2017;106:2946.

    Article  CAS  PubMed  Google Scholar 

  40. Thompson RA, Isin EM, Ogese MO, Mettetal JT, Williams DP. Reactive metabolites: current and emerging risk and hazard assessments. Chem Res Toxicol. 2016;29:505–33.

    Article  CAS  PubMed  Google Scholar 

  41. Pradeu T, Cooper EL. The danger theory: 20 years later. Front Immunol. 2012;3:287.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Pichler WJ, Hausmann O. Classification of drug hypersensitivity into allergic, p-i, and pseudo-allergic forms. Int Arch Allergy Immunol. 2016;171:166–79.

    Article  CAS  PubMed  Google Scholar 

  43. Warrington R, Silviu-Dan F. Drug allergy. Allergy Asthma Clin Immunol. 2011;7(Suppl 1):S10.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  44. Usui T, Naisbitt DJ. Human leukocyte antigen and idiosyncratic adverse drug reactions. Drug Metab Pharmacokinet. 2017;32:21–30.

    Article  CAS  PubMed  Google Scholar 

  45. Bielory L, Gascon P, Lawley TJ, Young NS, Frank MM. Human serum sickness: a prospective analysis of 35 patients treated with equine anti-thymocyte globulin for bone marrow failure. Medicine. 1988;67:40–57.

    Article  CAS  PubMed  Google Scholar 

  46. Karmacharya P, Poudel DR, Pathak R, Donato AA, Ghimire S, Giri S, Aryal MR, Bingham CO III. Rituximab-induced serum sickness: a systematic review. Semin Arthritis Rheum. 2015;45:334–40.

    Article  PubMed  Google Scholar 

  47. Posadas SJ, Pichler WJ. Delayed drug hypersensitivity reactions - new concepts. Clin Exp Allergy. 2007;37:989–99.

    Article  CAS  PubMed  Google Scholar 

  48. Wallace MR, Mascola JR, Oldfield EC. Red man syndrome: incidence, etiology, and prophylaxis. J Infect Dis. 1991;64:1180–5.

    Article  Google Scholar 

  49. Szebeni J. Complement activation-related pseudoallergy: a new class of drug-induced acute immune toxicity. Toxicology. 2005;216:106–21.

    Article  CAS  PubMed  Google Scholar 

  50. Szebeni J, Muggia F, Gabizon A, Barenholz Y. Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: prediction and prevention. Adv Drug Deliv Rev. 2011;63:1020–30.

    Article  CAS  PubMed  Google Scholar 

  51. van der Kolk LE, Grillo-López AJ, Baars JW, Hack CE, van Oers MH. Complement activation plays a key role in the side-effects of rituximab treatment. Br J Haematol. 2001;115:807–11.

    Article  PubMed  Google Scholar 

  52. de Weck AL, Gamboa PM, Esparza R, Sanz ML. Hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). Curr Pharm Des. 2006;12:3347–58.

    Article  PubMed  Google Scholar 

  53. Byrd JB, Adam A, Brown NJ. Angiotensin-converting enzyme inhibitor-associated angioedema. Immunol Allergy Clin North Am. 2006;26:725–37.

    Article  PubMed  Google Scholar 

  54. Cooper GS, Stroehla BC. The epidemiology of autoimmune diseases. Autoimmun Rev. 2003;2:119–25.

    Article  PubMed  Google Scholar 

  55. Vial T, Nicolas B, Descotes J. Drug-induced autoimmunity: experience of the French pharmacovigilance system. Toxicology. 1997;119:23–7.

    Article  CAS  PubMed  Google Scholar 

  56. Vial T, Descotes J. Immune-mediated side-effects of cytokines in humans. Toxicology. 1995;105:31–57.

    Article  CAS  PubMed  Google Scholar 

  57. McKoy JM, Stonecash RE, Cournoyer D, Rossert J, Nissenson AR, Raisch DW, Casadevall N, Bennett CL. Epoetin-associated pure red cell aplasia: past, present, and future considerations. Transfusion. 2008;48:1754–62.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Day D, Hansen AR. Immune-related adverse events associated with immune checkpoint inhibitors. BioDrugs. 2016;30:571–84.

    Article  CAS  PubMed  Google Scholar 

  59. Pérez-De-Lis M, Retamozo S, Flores-Chávez A, Kostov B, Perez-Alvarez R, Brito-Zerón P, Ramos-Casals M. Autoimmune diseases induced by biological agents. A review of 12,731 cases (BIOGEAS Registry). Expert Opin Drug Saf. 2017;16:1255–71.

    Article  PubMed  CAS  Google Scholar 

  60. Rubin RL. Drug-induced lupus. Expert Opin Drug Saf. 2015;14:361–78.

    Article  CAS  PubMed  Google Scholar 

  61. Vellozzi C, Iqbal S, Broder K. Guillain-Barre syndrome, influenza, and influenza vaccination: the epidemiologic evidence. Clin Infect Dis. 2014;58:1149–55.

    Article  PubMed  Google Scholar 

  62. Langer-Gould A, Qian L, Tartof SY, Brara SM, Jacobsen SJ, Beaber BE, Sy LS, Chao C, Hechter R, Tseng HF. Vaccines and the risk of multiple sclerosis and other central nervous system demyelinating diseases. JAMA Neurol. 2014;71:1506–13.

    Article  PubMed  Google Scholar 

  63. Penn AS, Low BW, Jaffe IA, Luo L, Jacques JJ. Drug-induced autoimmune myasthenia gravis. Ann N Y Acad Sci. 1998;841:433–49.

    Article  CAS  PubMed  Google Scholar 

  64. Duntas LH. Environmental factors and autoimmune thyroiditis. Nat Clin Pract Endocrinol Metab. 2008;4:454–60.

    Article  CAS  PubMed  Google Scholar 

  65. Beaune PH, Lecoeur S. Immunotoxicology of the liver: adverse reactions to drugs. J Hepatol. 1997;26(Suppl 2):37–42.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jacques Descotes .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer International Publishing AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Descotes, J. (2019). Immune Response in Human Pathology: Hypersensitivity and Autoimmunity. In: Parnham, M., Nijkamp, F., Rossi, A. (eds) Nijkamp and Parnham's Principles of Immunopharmacology. Springer, Cham. https://doi.org/10.1007/978-3-030-10811-3_11

Download citation

Publish with us

Policies and ethics