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The Sixth Sense Organs: The Immune System

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Biophysics and Neurophysiology of the Sixth Sense

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Abstract

Non-nervous systems particularly endocrine and immune systems interact with the nervous system. As a result, nervous system-related features favorably sensory perception can be found in as well as out of the nervous tissues.

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References

  1. Stansbury K, Gunnar MR. Adrenocortical activity and emotion regulation. Monogr Soc Res Child Dev. 1994;59(2–3):108–34.

    Article  CAS  Google Scholar 

  2. Blalock JE. The immune system as a sensory organ. J Immunol. 1984;132(3):1067–70.

    CAS  PubMed  Google Scholar 

  3. Blalock JE. The immune system as the sixth sense. J Intern Med. 2005;257(2):126–38.

    Article  CAS  Google Scholar 

  4. Blalock JE, Smith EM. Conceptual development of the immune system as a sixth sense. Brain Behav Immun. 2007;21(1):23–33.

    Article  CAS  Google Scholar 

  5. Blalock JE. A molecular basis for bidirectional communication between the immune and neuroendocrine systems. Physiol Rev. 1989;69(1):1–32.

    Article  CAS  Google Scholar 

  6. Beishuizen A, Thijs LG. Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis. J Endotoxin Res. 2003;9(1):3–24.

    CAS  PubMed  Google Scholar 

  7. Besedovsky H, et al. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science. 1986;233(4764):652–4.

    Article  CAS  Google Scholar 

  8. Besedovsky H, et al. Short papers. Eur J Immunol. 1977;7(5):323–5.

    Article  CAS  Google Scholar 

  9. Banks WA. Blood-brain barrier transport of cytokines: a mechanism for neuropathology. Curr Pharm Des. 2005;11(8):973–84.

    Article  CAS  Google Scholar 

  10. Johnson AK, Gross PM. Sensory circumventricular organs and brain homeostatic pathways. FASEB J. 1993;7(8):678–86.

    Article  CAS  Google Scholar 

  11. Breder CD, Dinarello CA, Saper CB. Interleukin-1 immunoreactive innervation of the human hypothalamus. Science. 1988;240(4850):321–4.

    Article  CAS  Google Scholar 

  12. Breder CD, et al. Regional induction of tumor necrosis factor alpha expression in the mouse brain after systemic lipopolysaccharide administration. Proc Natl Acad Sci. 1994;91(24):11393.

    Article  CAS  Google Scholar 

  13. Meisel C, et al. Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci. 2005;6(10):775.

    Article  CAS  Google Scholar 

  14. Tracey KJ. The inflammatory reflex. Nature. 2002;420(6917):853.

    Article  CAS  Google Scholar 

  15. Jansen ASP, et al. Central command neurons of the sympathetic nervous system: basis of the fight-or-flight response. Science. 1995;270(5236):644–6.

    Article  CAS  Google Scholar 

  16. Woiciechowsky C, et al. Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury. Nat Med. 1998;4(7):808.

    Article  CAS  Google Scholar 

  17. Gleeson M, et al. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol. 2011;11(9):607.

    Article  CAS  Google Scholar 

  18. Chrousos GP. The hypothalamic–pituitary–adrenal axis and immune-mediated inflammation. N Engl J Med. 1995;332(20):1351–63.

    Article  CAS  Google Scholar 

  19. Barnes PJ. Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin Sci. 1998;94(6):557–72.

    Article  CAS  Google Scholar 

  20. Gaykema RP, Dijkstra I, Tilders FJ. Subdiaphragmatic vagotomy suppresses endotoxin-induced activation of hypothalamic corticotropin-releasing hormone neurons and ACTH secretion. Endocrinology. 1995;136(10):4717–20.

    Article  CAS  Google Scholar 

  21. Arnason BG, et al. Mechanisms of action of adrenocorticotropic hormone and other melanocortins relevant to the clinical management of patients with multiple sclerosis. Mult Scler (Houndmills, Basingstoke, England). 2013;19(2):130–6.

    Article  Google Scholar 

  22. Wang H, et al. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med. 2004;10(11):1216.

    Article  CAS  Google Scholar 

  23. Ulloa L. The vagus nerve and the nicotinic anti-inflammatory pathway. Nat Rev Drug Discov. 2005;4(8):673.

    Article  CAS  Google Scholar 

  24. Jonge WJ, Ulloa L. The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation. Br J Pharmacol. 2009;151(7):915–29.

    Article  Google Scholar 

  25. Sopori M. Effects of cigarette smoke on the immune system. Nat Rev Immunol. 2002;2(5):372.

    Article  CAS  Google Scholar 

  26. Alkondon M, et al. Choline is a selective agonist of α7 nicotinic acetylcholine receptors in the rat brain neurons. Eur J Neurosci. 1997;9(12):2734–42.

    Article  CAS  Google Scholar 

  27. Bencherif M, et al. Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases. Cell Mol Life Sci. 2011;68(6):931–49.

    Article  CAS  Google Scholar 

  28. Martin LF, Kem WR, Freedman R. Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia. Psychopharmacology. 2004;174(1):54–64.

    Article  CAS  Google Scholar 

  29. Kem WR. The brain α7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer’s disease: studies with DMXBA (GTS-21). Behav Brain Res. 2000;113(1–2):169–81.

    Article  CAS  Google Scholar 

  30. Borovikova LV, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 2000;405(6785):458.

    Article  CAS  Google Scholar 

  31. Zhang Y, et al. Chronic vagus nerve stimulation improves autonomic control and attenuates systemic inflammation and heart failure progression in a canine high-rate pacing modelclinical perspective. Circ Heart Fail. 2009;2(6):692–9.

    Article  CAS  Google Scholar 

  32. Bonaz B, et al. Chronic vagus nerve stimulation in Crohn’s disease: a 6-month follow-up pilot study. Neurogastroenterol Motil. 2016;28(6):948–53.

    Article  CAS  Google Scholar 

  33. Koopman FA, et al. Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis. Proc Natl Acad Sci. 2016;113(29):8284–9.

    Article  CAS  Google Scholar 

  34. Mauskop A. Vagus nerve stimulation relieves chronic refractory migraine and cluster headaches. Cephalalgia. 2005;25(2):82–6.

    Article  CAS  Google Scholar 

  35. Rush AJ, et al. Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study∗. Biol Psychiatry. 2000;47(4):276–86.

    Article  CAS  Google Scholar 

  36. Wernicke JF, Terry Jr RS, Baker Jr RG. Treatment of eating disorders by nerve stimulation. 1993, Google Patents.

    Google Scholar 

  37. Wernicke JF, Terry Jr RS. Treatment of endocrine disorders by nerve stimulation. 1993, Google Patents.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Molecular Immunology Research Center, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Amene Saghazadeh

  2. MetaCognition Interest Group (MCIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Amene Saghazadeh

  3. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

  4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

  5. Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Nima Rezaei

Authors
  1. Amene Saghazadeh
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  2. Nima Rezaei
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Corresponding author

Correspondence to Nima Rezaei .

Editor information

Editors and Affiliations

  1. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

  2. Molecular Immunology Research Center, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Amene Saghazadeh

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Saghazadeh, A., Rezaei, N. (2019). The Sixth Sense Organs: The Immune System. In: Rezaei, N., Saghazadeh, A. (eds) Biophysics and Neurophysiology of the Sixth Sense. Springer, Cham. https://doi.org/10.1007/978-3-030-10620-1_20

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