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On the Immune Status of Patients with Colorectal Carcinoma

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Emergency Surgical Management of Colorectal Cancer

Part of the book series: Hot Topics in Acute Care Surgery and Trauma ((HTACST))

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Abstract

This chapter emphasizes the consequences of an immunocompromised status in patients with colorectal malignancies. In general, one can differentiate between the types of neoplasms through their location, genesis, as well as their specific cell structures and characteristics. Differentiation between these entities is meaningful, since it provides insights into the pathogenesis of colorectal neoplasms. Escape mechanisms can help tumor cells to avoid immunological control to start metastatic spread. Not only anatomy but also distinction in gene expression profiles and pathway activity can help to determine cancer-specific tumor progression and clinical outcome facilitating the development of new therapeutic targets. Other distinct endogenous factors as patients’ genetic background and immunodeficiency, together with exogenous factors as lifestyle, dietary intake and exposure to environmental stress determine the immunological status of a colorectal cancer patient.

In order to get a clear view on the complex factors that contribute to tumor development, progression and metastasis, immunological aspects must certainly not be ignored.

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Authors and Affiliations

  1. Department of Surgery, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands

    Pim P. Edomskis, Daniël P. V. Lambrichts & Johan F. Lange

  2. Department of Surgery, IJsselland Ziekenhuis, Capelle aan den IJssel, The Netherlands

    Johan F. Lange

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  1. Pim P. Edomskis
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  2. Daniël P. V. Lambrichts
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  3. Johan F. Lange
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Correspondence to Pim P. Edomskis .

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Editors and Affiliations

  1. Department of General Surgery Unit of Digestive, Minimally Invasive and Robotic Surgery, Henri Mondor Hospital, Créteil, France

    Nicola de'Angelis

  2. Cambridge Colorectal Unit, Cambridge Biomedical Campus, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke’s Hospital, Cambridge, UK

    Salomone Di Saverio

  3. Department of General Surgery Unit of Digestive, Minimally Invasive and Robotic Surgery, Henri Mondor Hospital, Créteil, France

    Francesco Brunetti

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Edomskis, P.P., Lambrichts, D.P.V., Lange, J.F. (2019). On the Immune Status of Patients with Colorectal Carcinoma. In: de'Angelis, N., Di Saverio, S., Brunetti, F. (eds) Emergency Surgical Management of Colorectal Cancer. Hot Topics in Acute Care Surgery and Trauma. Springer, Cham. https://doi.org/10.1007/978-3-030-06225-5_14

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  • DOI: https://doi.org/10.1007/978-3-030-06225-5_14

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