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A Novel Strategy for the Surface Modification of Superparamagnetic (Fe3O4) Iron Oxide Nanoparticle for Lung Cancer Imaging

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Surface Modification of Nanoparticles for Targeted Drug Delivery

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Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) have recently gained interest due to their low toxicity, biocompatibility, magnetic potential, and catalytic nature. Their biocompatible nature makes them suitable candidate for biomedical applications. SPIONs are considered as inert and used in different areas such as imaging, targeted drug delivery and biosensors. Their surfaces can be modified using different coating and labeling agents which has broaden their role in diagnosis and nanomedicine applications. SPIONs have got wide range of applications in biomedical and healthcare industry such as drug-delivery vehicle for chemotherapeutic drugs, an agent to induce heat mediated killing of cancer cells (hyperthermia) and as contrast agent in magnetic resonance imaging (MRI). More often SPIONs are used for simultaneous image guided delivery of chemotherapeutic drugs to the tumor cells and hyperthermia is used synergistically to enhance the overall lethal effect of the whole treatment process toward tumor cells. In this chapter, we discuss different strategies for surface modification of SPIONs and their applications for diagnosis and treatment of lung cancer.

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Author information

Authors and Affiliations

  1. Department of Nanotechnology, North Eastern Hill University, Shillong, Meghalaya, India

    Mayank Bhushan

  2. Department of Biochemistry and Molecular Biology, Pondicherry University, Puducherry, India

    Yogesh Kumar

Authors
  1. Mayank Bhushan
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  2. Yogesh Kumar
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Editors and Affiliations

  1. College of Pharmacy, University of South Florida, Tampa, FL, USA

    Yashwant V Pathak

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Bhushan, M., Kumar, Y. (2019). A Novel Strategy for the Surface Modification of Superparamagnetic (Fe3O4) Iron Oxide Nanoparticle for Lung Cancer Imaging. In: Pathak, Y. (eds) Surface Modification of Nanoparticles for Targeted Drug Delivery. Springer, Cham. https://doi.org/10.1007/978-3-030-06115-9_8

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