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Surface Modification and Bioconjugation of Nanoparticles for MRI Technology

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Book cover Surface Modification of Nanoparticles for Targeted Drug Delivery

Abstract

Nanomaterials (NPs) with precise biological functions have considerable potential for use in biomedical applications. Surface modification is one of the effective routes to impart such desired and precise biological functions to NPs. Introduction of various reactive functional groups on the surface of NPs are required to conjugate a spectrum of contrast agents (CAs), for the targeted imaging such as magnetic resonance imaging (MRI). Current state in surface modification of NPs for preparing CAs of MRI is summarized in this chapter. Chemistries involved in the bioconjugation and surface modification are discussed. Chemical and bioconjugate reactions to transform the surface of NPs such as silica NPs, gold NPs, and gadolinium NPs are highlighted. Coating is another important approach to enhance the functionalities of CAs for MRI application, therefore, light is thrown on the coating mechanism of organic polymers including dextran, chitosan, and copolymers.

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Authors and Affiliations

  1. Centre for Bioengineering and Nanomedicine, Department of Food Science, Division of Sciences, University of Otago, Dunedin, New Zealand

    M. Azam Ali

  2. Centre for Materials Science and Technology, University of Otago, Dunedin, New Zealand

    Mohammad Tajul Islam

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  1. College of Pharmacy, University of South Florida, Tampa, FL, USA

    Yashwant V Pathak

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Ali, M.A., Islam, M.T. (2019). Surface Modification and Bioconjugation of Nanoparticles for MRI Technology. In: Pathak, Y. (eds) Surface Modification of Nanoparticles for Targeted Drug Delivery. Springer, Cham. https://doi.org/10.1007/978-3-030-06115-9_21

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