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Pathogenesis of Fungal Infections

  • Chandrasekhar Srinivasamurthy Banushree
  • Neriyana Sannappa Madhusudhan
Chapter

Abstract

Invasive fungal infections can cause significant morbidity and mortality as they are more difficult to treat. Understanding of the pathogenesis of fungal infections can aid in the prevention and management of the disease. Over a period of time, human beings have become a substrate for fungi. Apart from dysfunctional immune system of host, fungi are capable of tolerating high temperature and invading the human host tissue barrier to parasitize humans. Various immunoregulatory mechanisms determine the outcome of exposure to fungal pathogens. The following discussion intends to highlight the pathogenesis of fungal infections with special reference to central nervous system in humans.

Keywords

Central nervous system Fungal infections Genetic factors Immune system Immunoregulation Pathogenesis Predisposing conditions 

Abbreviations

ALS proteins

Agglutinin-like sequence proteins

CARD 9

Caspase recruitment domain-containing protein 9

CD

Cluster of differentiation

CLR

C-type lectin receptors

CNS

Central nervous system

CR

Complement receptor

CTLA-4

Cytotoxic T lymphocyte-associated protein 4

DC

Dendritic cell

DNA

Deoxyribonucleic acid

EC

Epithelial cell

EPA

Epithelial adhesin gene

HIV

Human immunodeficiency virus

Hsp

Heat shock protein

HYR

Hyphally regulated protein gene

IFN

Interferons

IL

Interleukin

IRIS

Immune reconstitution inflammatory syndrome

MR

Mannose receptors

NK

Natural killer

PAMP

Pathogen-associated molecular patterns

PD-1

Programmed cell death protein-1

PRR

Pattern recognition receptors

ROI

Reactive oxygen intermediates

Saps

Secreted aspartyl proteinases

Th

Thymus helper

TLO

Telomere-associated gene

TLR

Toll-like receptor

TNF-α

Tumor necrosis factor α

Treg cells

Regulatory T cells

YWP

Yeast-form wall protein

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Chandrasekhar Srinivasamurthy Banushree
    • 1
  • Neriyana Sannappa Madhusudhan
    • 2
  1. 1.Department of PathologyIndira Gandhi Medical college and Research InstitutePuducherryIndia
  2. 2.Department of MicrobiologyIndira Gandhi Medical College and Research InstitutePuducherryIndia

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