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Imaging of Fungal Infections of the Brain

  • Subhendu ParidaEmail author
Chapter

Abstract

Cell-mediated immunity is the primary line of defense against fungal infections; in immunocompromised patients, invasive infections occur in various organ systems including the central nervous system (CNS). In the CNS, meningeal and parenchymal disease can occur. The pathological hallmark of fungal infections is angioinvasion; it can explain several manifestations of the disease. Imaging closely follows the pathological changes.

Yeasts like Candida and Cryptococcus produce leptomeningitis commonly; hyphal organisms like Aspergillus spp. and Mucor spp. produce granulomas and abscesses. Vascular invasion can lead to stenosis, thrombosis, and mycotic aneurysm formation.

Keywords

Magnetic resonance imaging Fungal infections Fungal granuloma Fungal abscess Mycotic aneurysm 

Abbreviations

CNS

Central nervous system

CSF

Cerebrospinal fluid

CT

Computed tomography

DSA

Digital subtraction angiography

DTI

Diffusion tensor imaging

DWI

Diffusion-weighted imaging

FDG

Fluorodeoxyglucose

FLAIR

Fluid-attenuated inversion recovery

HIV-AIDS

Human immunodeficiency virus-acquired immunodeficiency syndrome

MRI

Magnetic resonance imaging

MRS

Magnetic resonance spectroscopy

MT

Magnetization transfer

PET-CT

Positron emission tomography-computed tomography

ppm

Parts per million

SWI

Susceptibility-weighted imaging

VR

Virchow-Robin

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of RadiologyCARE HospitalsHyderabadIndia
  2. 2.Department of NeurologyCARE HospitalsHyderabadIndia

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