Abstract
Eyelid adnexal tumors are frequent and comprise a large variety of different entities of benign and malignant tumors. Adnexal lesions may arise from hairs and various glands such as eccrine, apocrine, and sebaceous glands which are part of the eyelid anatomy. Overall, benign adnexal lesions of the eyelids are much more frequent than the malignant lesions. In this chapter, cystic lesions, sweat gland tumors, hair follicle tumors, and sebaceous gland tumors are covered including a classification of eyelid adnexal tumors. Besides clinical findings, treatment, follow-up, and prognosis, the histologic features of eyelid adnexal tumors are described. This chapter is richly illustrated providing a clinico-pathological correlation of common adnexal tumors.
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References
Kersten RC, Ewing-Chow D, Kulwin DR, et al. Accuracy of clinical diagnosis of cutaneous eyelid lesions. Ophthalmology. 1997;104(3):479–84.
Margo CE. Eyelid tumors: accuracy of clinical diagnosis. Am J Ophthalmol. 1999;128(5):635–6.
Deprez M, Uffer S. Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature. Am J Dermatopathol. 2009;31(3):256–62.
Warwick R, Williams PL. Gray’s anatomy. 35th ed. Edinburgh: Longman Group Ltd; 1973. p. 1168–9.
Warwick R. Eugene Wolf’s anatomy of the and orbit. 7th ed. London: H.K. Lewis & Co. Ltd; 1976. p. 195–7.
Smith JD, Chernosky ME. Apocrine hidrocystoma (cystademnoma). Arch Dermatol. 1974;109(5):700–2.
Sacks E, Jakobiec FA, McMillan R, et al. Multiple bilateral apocrine cystadenomas of the lower eyelids. Light and electron microscopic studies. Ophthalmology. 1987;94(1):65–71.
Alessi E, Gianotti R, Coggi A. Multiple apocrine hidrocystomas of the eyelids. Br J Dermatol. 1997;137(4):642–5.
Verplancke P, Driessen L, Wynants P, et al. The Schopf-Schulz-Passarge syndrome. Dermatology. 1998;196(4):463–6.
Smith JD, Chernosky ME. Hidrocystomas. Arch Dermatol. 1973;108(5):676–9.
Robinson R. Hidrocystoma. J Cutan Genitourinary Dis. 1893;11:293–303.
Singh AD, McCloskey L, Andrew Parsons M, et al. Eccrine hidrocystoma of the eyelid. Eye. 2005;19:77–9.
Lee SJ, Cho S, Cho SB. Syringomas versus sebaceous gland prominence of the eyelids. J Cosmet Laser Ther. 2011;13(3):130–1.
Alyahya GA, Stenman G, Persson F, et al. Pleomorphic adenoma arising in an accessory lacrimal gland of Wolfring. Ophthalmology. 2006;113(5):879–82.
Jordan DR, Nerad JA, Patrinely JR. Chondroid syringoma of the eyelid. Can J Ophthalmol. 1989;24(1):24–7.
Barbarino S, McCormick SA, Lauer SA, et al. Syringocystadenoma papilliferum of the eyelid. Ophthalmic Plast Reconstr Surg. 2009;25(3):185–8.
Behera M, Chatterjee S. A case of syringocystadenoma papilliferum of eyelid with literature review. Indian J Ophthalmol. 2015;63(6):550–1.
Esmaeli B, Ramsay JA, Chorneyko KA, et al. Sclerosing sweat-duct carcinoma (malignant syringoma) of the upper eyelid: a patient report with immunohistochemical and ultrastructural analysis. Ophthal Plast Reconstr Surg. 1998;14(6):441–5.
Boynton JR, Markowitch W Jr. Mucinous eccrine carcinoma of the eyelid. Arch Ophthalmol. 1998;116(8):1130–1.
Paridaens D, Mooy CM. Apocrine sweat gland carcinoma. Eye (Lond). 2001;15(Pt 2):253–4.
Hunold AC, Herwig MC, Holz FG, et al. Pigmented tumour of the eyelid with unexpected findings. Case Rep Pathol. 2012;2012:471368.
Aurora AL. Solitary trichoepithelioma of the eyelid. Indian J Ophthalmol. 1974;22(2):32–3.
Brooke JD, Fitzpatrick JE, Golitz LE. Papillary mesenchymal bodies: a histologic finding useful in differentiating trichoepitheliomas from basal cell carcinomas. J Am Acad Dermatol. 1989;21(3 Pt 1):523–8.
Tellechea O, Cardoso JC, Reis JP, et al. Benign follicular tumors. An Bras Dermatol. 2015;90(6):780–96; quiz 97–8.
Carreras B Jr, Lopez-Marin I Jr, Mellado VG, et al. Trichofolliculoma of the eyelid. Br J Ophthalmol. 1981;65(3):214–5.
Shields JA, Shields CL, Eagle RC Jr. Trichoadenoma of the eyelid. Am J Ophthalmol. 1998;126(6):846–8.
Hidayat AA, Font RL. Trichilemmoma of eyelid and eyebrow. A clinicopathologic study of 31 cases. Arch Ophthalmol. 1980;98(5):844–7.
Bardenstein DS, McLean IW, Nerney J, et al. Cowden’s disease. Ophthalmology. 1988;95(8):1038–41.
Boniuk M, Zimmerman LE. Pilomatrixoma (benign calcifying epithelioma) of the eyelids and eyebrow. Arch Ophthalmol. 1963;70:399–406.
Yap EY, Hohberger GG, Bartley GB. Pilomatrixoma of the eyelids and eyebrows in children and adolescents. Ophthalmic Plast Reconstr Surg. 1999;15(3):185–9.
Herwig MC, Vogel A, Holz FG, et al. Pilomatrixoma of the ocular adnexae: clinical and histologic analysis (13 cases). Klin Monatsbl Augenheilkd. 2009;226(5):404–8.
Jones C, Twoon M, Ho W, et al. Pilomatrix carcinoma: 12-year experience and review of the literature. J Cutan Pathol. 2018;45(1):33–8.
Cahill MT, Moriarty PM, Mooney DJ, et al. Pilomatrix carcinoma of the eyelid. Am J Ophthalmol. 1999;127(4):463–4.
Singh AD, Mudhar H, Bhola R, et al. Sebaceous adenoma of the eyelid in Muir-Torre syndrome. Arch Ophthalmol. 2005;123:562–5.
Mittal R, Tripathy D. Sebaceoma of the eyelid: a rare entity. Can J Ophthalmol. 2014;49(3):e78–80.
Yonekawa Y, Jakobiec FA, Zakka FR, et al. Sebaceoma of the eyelid. Ophthalmology. 2012;119(12):2645 e1–4.
Abbas O, Mahalingam M. Cutaneous sebaceous neoplasms as markers of Muir-Torre syndrome: a diagnostic algorithm. J Cutan Pathol. 2009;36(6):613–9.
McKee PH. Sebaceous epithelioma pathology of the skin with clinical correlations. London: Mosby; 1996.
Traboulsi EI, Zin A, Massicotte SJ, et al. Posterior scleral choristoma in the organoid nevus syndrome (linear nevus sebaceus of Jadassohn). Ophthalmology. 1999;106(11):2126–30.
Cribier B, Scrivener Y, Grosshans E. Tumors arising in nevus sebaceus: a study of 596 cases. J Am Acad Dermatol. 2000;42(2 Pt 1):263–8.
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Herwig-Carl, M.C., Loeffler, K.U. (2019). Adnexal Tumors. In: Pe'er, J., Singh, A., Damato, B. (eds) Clinical Ophthalmic Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-06046-6_8
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