Abstract
Hydrogels are three-dimensional polymer structures that can captivate and hold a vast quantity of water. They have superior’s properties such as hydrophilicity, high swelling ability, non-toxic in nature, and biocompatibility which makes them prospective materials for various applications. The concept of graft copolymers in biomedical field developed in the past few ten years and lasts to fascinate researchers working in this sector. Research in this sector is ongoing with the aim of alteration of the inherent properties of polysaccharides after grafting, which offers premises to be pervasive in integrated systems with multiple functionalities or the enhanced properties of one domain. This chapter aims to give comprehensive details about research that have been made on radiation-induced synthesis of polysaccharide-based hydrogels in context to biomedical application. This review also intends to explain the mechanism of radiation-induced synthesis of hydrogels. The effect of various radiation sources such as gamma, microwave, electron, and heavy ions is also discussed. Also, current status and plans of hydrogels are presented along with proper citations extracted from the scientific literature. Moreover, this article provides you with essential information that one’s need to start work in this area.
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Walter R, Brian Saunders R (2014) Soft Matter 10:3695
Sharma K (2015) Synthesis of conducting gum ghatti-PANI based interpenetrating networks and their applications as controlled drug delivery devices. A Thesis submitted to the Faculty of Basic Sciences Shoolini University of Biotechnology and Management Sciences, Solan (Himachal Pradesh), 173229 (India)
Campbell TD (2007) Synthesis and physical characterization of biocompatible hydrogels. Department of Chemistry and Biochemistry, The Florida State University
Flory PJ (1941) J Chem Phy 9:660
Flory PJ (1941) J Am Chem Soc 63:3083
Huggins ML (1942) J Am Chem Soc 64:1712
Huggins ML (1943) Ind Eng Chem 35:216
Treloar LRG (1951) Chem Ind 45:955
Treloar LRG (1952) The thermodynamic study of rubber-like elasticity. Proc R Soc London Series B Biol Sci 139:506
Kumar V (2013) Characterization of conducting polymer composites & non-conducting polymers with exposure of neutrons, gamma rays and charged particles. Department of Physics, Sant Longowal Institute of Engineering and Technology, Longowal (Sangrur), Punjab (India)
Qinyuan C, Yang J, Xinjun Y (2017) Gels 3:6
Rabinarayan P (2017) Adv Pharm Bull 7(4):515
Jones DS, Andrews GP, Gorman SP (2005) J Pharm Pharmacol 57:1251
Hoffman AS (2002) Adv Drug Del Rev 54:3
Enas MA (2015) J Adv Res 6:105
Sastry SK, Lakonishok M, Wu S, Truong TQ, Huttenlocher A, Turner CE, Horwitz AF (1999) J Cell Bio 144:1295
Smetana K Jr, Vacík J, Součková D, Krčová Z, Šulc J (1990) J Biomed Mater Res 24:463
Kashma S, Vijay K, Kaith BS, Vinod K, Sudipta Som, Anurag P, Susheel K, Swart HC (2015) New J Chem 39:3021
Sharma K, Kumar V, Kaith BS, Kalia S, Swart HC (2017) Conducting polymer hydrogels and their applications. In: Kumar V, Kalia S, Swart HC (eds) Conducting polymer hybrids. Springer International Publishing
Yinan W, Christian KA, Ravin N (2018) Exp Opin Drug Del 15:77
Bell CL, Peppas NA (1995) Adv Polym Sci 122:125
Enrica C, Vitaliy VK (2015) Europ Polym J 65:252
Derek GP, Peter JS, Brian JT (1980) Polym Int 12:99
Nemours EIP (1936) Ind Eng Chem 28:1160
Wichterle O, Lim D (1960) Nature 185:117
Hoffman AS (1987) J Control Release 6:297
Hoffman AS (2012) Adv Drug Del Rev 64:18
Duncan R (2006) Nat Rev Cancer 6:688
MacEwan SR, Callahan DJ, Chilkoti A (2010) Nanomedicine (Lond) 5:793
Aliaghaie M, Mirzadeh H, Dashtimoghadam E, Taranejoo S (2012) Soft Matter 8:7128
Bita T, Shahrouz T, Seyed AM, Zoha SM, Karim D, Hossein D, Zaynab D (2014) Drug Del 22:145
Kashma S, Kaith BS, Vijay K, Susheel K, Vinod K, Swart HC (2014) Geoderma 232–234:45
Kashma S, Vijay K, Kaith BS, Sudipta S, Vinod K, Anurag P, Kalia S, Swart HC (2015) Ind Eng Chem Res 54:1982
Kashma S, Kaith BS, Susheel K, Vijay K, Swart HC (2015) Colloid Polym Sci 293:1181
Kashma S, Vijay K, Kaith BS, Vinod K, Sudipta S, Susheel K, Swart HC (2015) Polym Degrad Stab 111:20
Kashma S, Kaith BS, Vijay K, Vinod K, Sudipta S, Susheel K, Swart HC (2013) RSC Adv 3:25830
John AH, Rui C, van Theun V, Nicholas B (2014) J Mater Chem B 2:5319
Kirchmajer DM, Gorkin R, in het Panhuis M (2015) J Mater Chem B 3:4105
Takashi L, Hatsumi T, Makoto M, Takashi I, Takehiko G, Shuji S (2007) J Appl Polym Sci 104:842
Yang L, Chu JS, Fix JA (2002) Int J Pharm 235:1
Aylsworth JW (1914) US Patent 1111:284
Millar JRJ (1960) J Chem Soc 263:1311
Matricardi P, Meo CD, Coviello T, Hennink WE, Alhaique F (2013) Adv Drug Del Rev 65:1172
Jones SD, Andrews PG, Caldwell LD, Lorimer C, Gorman PS, McCoy CP (2012) Eur J Pharm Biopharm 82:563
Maolin Z, Jun L, Min Y, Hongfei H (2000) Radiat Phy Chem 58:397
Jenkins AD, Kratochvil P, Stepto RFT, Suter UW (1996) Pure Appl Chem 68:2287
Bhattacharya A, Misra BN (2004) Prog Polym Sci 29:767
Athawale VD, Vidyagauri L (1998) Carbohyd Polym 35:21
Mohammad RS, Abel M, Mohammad AR (2009) Carbohyd Polym 77:634
Celli A, Sabaa MW, Jyothi AN, Kalia S (2016) Chitosan and starch-based hydrogels via graft copolymerization. In: Kalia S (ed) Polymeric hydrogels as smart biomaterials. Springer International Publishing, pp 189–234
Chauhan A, Chauhan P, Kaith BS (2012) J Chem Eng Process Tech 3:1
Chauhan GS, Kaur I, Misra BN, Singha AS, Kaith BS (2000) Polym Degrad Stab 69:261
Chauhan GS, Kaur I, Misra BN, Singha AS, Kaith BS (1999) J Polym Mater 16:245
Sharma BR, Kumar V, Sen PL (2003) J Macromol Sci, Part A. Pure Appl Chem 40:49
Mittal H, Mishra SB, Mishra AK, Kaith BS, Jindal R, Kalia S (2013) Carbohydrate Polym 98:397
Mittal H, Mishra SB, Mishra AK, Kaith BS, Jindal R (2013) Int J Biolog Macromol 58:37
Berlin AA, Kislenko VN (1992) Prog Polym Sci 17:765
Hennink WE, van Nostrum CF (2002) Adv Drug Deliv Rev 54(1):13
Chun-Liang Y (2010) Investigation of electrophoretic loading and enhanced mechanical properties of hydrogels for delivery of therapeutic proteins. Faculty of Sciences and Technology, The Queensland University of Technology
Crini G (2005) Prog Polym Sci 30:38
Taleb MFA (2013) Int J Biolog Macromol 62:341
Nam IK, Mun GA, Urkimbaeva PI, Nurkeeva ZS (2003) Rad Phys Chem 66:281
Henke A, Kadlubowski S, Ulanski P, Rosiak JM, Arndt KF (2005) Nucl Instrum Meth Phys Res B 236:391
David JT, Hill AK, Whittaker Z (2011) Rad Phys Chem 80:213
Sung-Eun P, Young-Chang N, Hyung-Il K (2004) Rad Phys Chem 69:221
Hossen KM, Azim AM, Chowdhury AMS, Dafader NC, Haque ME, Akter F (2008) Polym Plas Tech Eng 47:662
Zainuddin H, Hill DJT, Whittaker AK (2007) J Biomed Mater Res, Part A 83A:54
Zainuddin H, Strounina DJT, Whittaker AK (2004) Soft Mater 2:195
Sakurada I, Ikada Y (1963) Bull Inst Chem Res Kyoto Univ 41(1):103
Kaetsu I (1981) Radiat Phys Chem 18:343
Kaetsu I (1985) Radiat Phys Chem 25:517
Hoffman AS, Allan S (1977) Radiat Phys Chem 18:323
Rosiak J, Rucinska-Rybus A, Pekala W (1989) US Patent No. 4871490 A
Sun Y, Chmielewski AG (eds) (2017) Applications of ionizing radiation in materials processing. Erasmus+
Guven O, Sen M, Karadag E, Saraydin D (1999) Radiat Phys Chem 56:381
Kume T, Nagasawa N, Yoshii F (2002) Radiat Phys Chem 63:625
Wach RA, Mitomo H, Nagasawa N, Yoshii F (2003) Radiat Phys Chem 68:771
Solpan D, Sibel D. Olgun G (2002) J Appl Polym Sci 86:3570
Alam MM, Chowdhury MA, Hina MF, Akhtar F, Kabir SE (2004) Chin J Polym Sci 22(3):253
Tuncer C, Simin K, Gokhan D (2006) J Appl Polym Sci 101(3):1756
Kashma S, Kaith BS, Vijay K, Susheel K, Vinod K, Swart HC (2014) Polym Degrad Stab 107:166
Seo KH, You SJ, Chun HJ (2009) Tiss Engg Regen Med 6:414
Taleb MFA, Sahar AI, El-Kelesh NA (2009) J Macromol Sc Part A 46:170
Lale IS, Selmiye AG (2011) J Appl Polym Sci 120:2313
Nasef MM, Hegazy ESA (2004) Prog Polym Sci 29:499–561
Gupta B, Jain R, Anjum N, Singh H (2006) Radiat Phys Chem 75:161
Binh D, Huy HT (1998) Radiat Phys Chem 53:177
Mohd YBH, Shahrir H, Wan AWAR (2017) Int J Polym Mater Polym Biomater 926
Tamás F, Judit B, Erzsébet T, László W (2017) Chem Cent J 11:46
Ghada AM, Samia E Abdel‐Aal, Nagwa AB, Samia AAF, Esraa AA (2014) Starch 66:400
Varshney L (2007) Nucl Instrum Meth Phys Res B 255:343
Baljit S, Lalit V, Sanju F, Rajneesh (2016) Int J Biolog Macromol 88:586
Baljit S, Lalit V, Sanju F, Rajneesh (2017) Radiat Phys Chem 135:94
Rohini D, Lok R, Ghanshyam SC (2012) J Appl Polym Sci 126:E260
Jayashree B, Virendra K, Bhardwaj YK, Goel NK, Dubey KA, Chaudhari CV, Sabharwal S (2007) Radiat Phys Chem 76:1624
Kappe CO (2004) Angew Chem Int Ed 43:6250
Prasad K, Mehta G, Meena R, Siddhanta AK (2006) J Appl Polym Sci 102:3654
Singh V, Singh SK, Maurya S (2010) Chem Eng J 160:129
Sen G, Singh RP, Pal S (2010) J Appl Polym Sci 115:63
Rani P, Sen G, Mishra S, Jha U (2012) Carbohydr Polym 89:275
Ghosh S, Sen G, Jha U, Pal S (2010) Bioresour Technol 101:9638
Kaith BS, Kashma S, Vijay K, Susheel K, Swart HC (2014) Synth Metals 187:61
Rani P, Sen G, Mishra S, Jha U (2012) Carbohydr Polym 89:275
Muhammad S, Shazia AB, Yousra G, Hira M, Fozia A, Mohammad Z, Tahir J, Khalid MZ (2013) Int J Bio Macromol 62:172
Mishra A, Shrinivasan R, Gupta RP (2003) Colloid Polym Sci 282:187
Singh V, Tripathi DN (2006) J Appl Polym Sci 15:2384
Singh V, Tiwari A, Tripathi DN, Sanghi R (2004) J Appl Polym Sci 5:1569
Chhatbar M, Meena R, Prasad K, Siddhanta A, Chhatbar MU, Meena R, Prasad K, Siddhanta AK (2009) Ind J Chem 48:1085
Maia AM, Silva HV, Curti PS, Balaban RC (2012) Carbohydr Polym 90:778
Singh V, Tiwari A, Tripathi DN, Sanghi R (2006) Polym 3:254
Sen G, Singh RP, Pal S (2010) J Appl Polym Sci 5:63
Singh V, Tiwari A, Pandey S, Singh SK (2006) Starke 1:536
Singh B, Chauhan GS, Sharma DK, Chauhan N (2007) Carbohydr Polym 19:559
Sagar P, Ghorai S, Dash MK, Ghosh S, Udayabhanu G (2011) J Hazard Mater 192:1580
Gautam S, Sumit M, Usha J, Sagar P (2010) Int J Biolog Macromol 47:164
Sumit M, Ankita M, Gautam S, Usha J (2011) Int J Biolog Macromol 48:106
Gautam S, Ranvijay K, Ghosh S, Sagar P (2009) Carbohyd Polym 77:822
Singh V, Kumar V, Sanghi R (2012) Prog Polym Sci 37:340
Gabriela C, Elena M, Maria DS (2016) J Chem 2016:1470965
Said HM, Abd Alla SG, El-Naggar AWM (2004) React Funct Polym 61:397
Fei B, Wach RA, Mitomo H, Yoshii F, Kume T (2000) J Appl Polym Sci 78:278
Liu P, Zhai M, Li J, Peng J, Wu J (2002) Radiat Phys Chem 63:525
Karadag E, Saraydin D, Güven O (2004) Nucl Instrum Meth Phys Res Sec B 225:489
Gonzalez-Martinez IG, Bachmatiuk A, Bezugly V, Kunstmann J, Gemming T, Liu Z, Cuniberti G, Rümmeli MH (2016) Nanoscale 8:11340
Branca C, Magazu S, Maisano G, Auditore L, Barna RC, Pasquale DD, Emanuele U, Trifiro A, Trimarchi M (2006) J Appl Polym Sci 102:820
Peppas NA (1986) Hydrogels in medicine and pharmacy. In: Fundamentals, vol 1. CRC Press, Boca Raton, FL
Rosiak JM, Ulanski P (1999) Radiat Phys Chem 55:139
Li HL, Ujihira Y, Shukushima S, Ueno K (2000) Polymer 41:93
Xu HS, Shanthi G, Bearti V, Zhang QM, Ramotowski T (2000) Macromol 33:4125
Ravat B, Grivet M, Grohens Y, Chambaudet A (2001) Radiat Meas 34:31
Arndt KF, Schmidt T, Reichelt R (2001) Polym 42:6785
Alegaonkar PS, Bhoraskar VN (2004) Radiat Eff Defects Solids 159:511
Torrisi L, Visco AM, Barna R, Pasquale DD, Campo N, Di Marco G, Trimarchi M, Trifiro A (2004) Radiat Eff Defects Solids 159:259
Othon CM, Bateman FB, Ducharme S (2005) J App Phys 98:014106
Cho SO, Jun HY (2005) Nucl Instrum Methods Phys Res, Sect B 237:525
Mazzoldi P, Arnold GW (1987) Ion beam modification of Insulators, vol. 2. Elsevier, Amsterdam
Mukherjee K, Gupta BD, Sharma PK (1986) J Macromol Sci Part B Polym Rev 26:415
Demertzis PG, Franz R, Welle F (1999) Packag Technol Sci 12:119
Huq T, Khan A, Dussault D, Salmieri S, Khan RA, Lacroix M (2012) Radiat Phys Chem 81:945
Kaith BS, Kashma S, Vijay K, Vinod K, Swart HC, Kalia S (2014) Vacuum 101:166
Kashma S, Kaith BS, Vijay K, Vinod K, Susheel K, Kapur BK, Swart HC. Radiat Phys Chem 97:253
Kaith BS, Rachna S, Kashma S, Choudhary S, Vijay K, Lochab SP (2015) Vacuum 111:73
Razem D, Katusin-Razem B (2008) Radiat Phys Chem 77:288
Tanaka TT, Tsuchiya K, Yajima H, Suzuki Y, Fukutome A (2011) Nucl Instrum Methods Phys Res B 269:2130
Tiwari VK, Singh NK, Avasthi DK, Misra M, Maiti P (2013) Radiat Phys Chem 82:92
Thaker MD, Trivedi HC (2005) J Appl Polym Sci 97:1977
Ozlem C, Dogan G, Seda K (2015) Acta Biomater 111:151
Gupta P, Vermani K, Garg S (2002) Drug Discovery Today 7:569
Hao Y, Shih H, Munoz Z, Kemp A, Lin CC (2014) Acta Biomater 10:104
Schoener CA, Hutson HN, Peppas NA (2012) Polym Int 61:874
Schoener CA, Hutson HN, Peppas NA (2012) J Biomed Mater Res Part A 101:2229
Yiting H, Han S, Zachary M, Arika K, Chien-Chi L (2014) Acta Biomater 10:101
Junli H, Yaping H, Hyejin P, Bogyu C, Siying H, Amy C, Min L (2012) Acta Biomater 8:1730
Bogyu C, Soyon K, Brian L, Kevin L, Olga B, Jinku K, Denis E, Tara A, Min L (2015) Acta Biomater 12:30
Huang L, Zhai ML, Long DW, Peng J, Xu L, Wu GZ, Li JQ, Wei GS (2008) J Nanopart Res 10:1193
Huang L, Zhai ML, Peng J, Xu L, Li JQ, Wei GS (2007) J Colloid Interface Sci 316:398
Kumar M, Varshney L, Francis S (2005) Radiat Phys Chem 73:21
Ying Z, Yinghui Z, Lu W, Ling X, Maolin Z, Shicheng W (2012) Radiat Phys Chem 81:553
Michael TP, Dianne LP, András EV, Mark SD, Al-Sheikhly MI (2018) Radiat Phys Chem 143:47
Ghaffar AMA, El-Arnaouty MB, Aboulfotouh ME, Taher NH, Taha AA (2014) Radiat Eff Def Solids 169:741
Amr El-Hag A, El-Sayed AH (2007) J Biomed Mater Res B Appl Biomater 81:168
Manal FAT (2013) Int J Biolog Macromol 62:341
Abd El-Mohdy HL, Hegazy EA, El-Nesr EM, El-Wahab MA (2016) Arab J Chem 9:S1627
Ajji Z, Othman I, Rosiak JM (2005) Nucl Instrum Meth Phys Res B 229:375
Sorour M, El-Sayed M, Moneem NAE, Talaat HA, Hayam S, Marsafy SE (2013) Starch 65:172
Kiran K, Kaith BS, Rajeev J, Hemant M (2012) J Appl Polym Sci 124:4969
Safaa GAA, Murat S, El-Naggar AWM (2012) Carbohydr Polym 89:478
Abd El-Mohdy HL, Abd El-Rehim HA (2009) J Polym Res 16:63
Acknowledgements
One of the authors (Kashma Sharma) is grateful to the University Grants Commission (UGC), New Delhi, for the award of Post-Doctoral Fellowship for Women [F.15-1/2017/PDFWM-2017-18-HIM-51703(SA-II)].
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Sharma, K., Sharma, V., Kumar, V. (2019). Synthesis of Hydrogels by Modification of Natural Polysaccharides Through Radiation Cross-Linking Polymerization for Use in Drug Delivery. In: Kumar, V., Chaudhary, B., Sharma, V., Verma, K. (eds) Radiation Effects in Polymeric Materials. Springer Series on Polymer and Composite Materials. Springer, Cham. https://doi.org/10.1007/978-3-030-05770-1_8
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