Synthesis and Characterization of PVP/CaCO3-Ag Blend Hydrogel by Gamma Irradiation: Study of Drug Delivery System and Antimicrobial Activity

  • Angelica Tamiao ZafalonEmail author
  • Vinícius dos Santos Juvino
  • Luiz Gustavo Hiroki Komatsu
  • Duclerc Fernandes Parra
  • Ademar Lugao
  • Temesgen Samuel
  • Vijaya Rangari
Conference paper
Part of the The Minerals, Metals & Materials Series book series (MMMS)


Chronic wounds are skin injuries with failed healing. They have become a public health problem that affects more than 2% of the population and the presence of bacteria resistances difficult of treatment. Pseudomonas aeruginosa is opportunist pathogens and the treatment is difficult and requires a long period of treatment. Hydrogels are structure polymeric tridimensional and biocompatible. They have been used as a controlled delivery system for treatment of topic infection. Studies have reported calcium carbonate and silver ion can improve the mechanical properties and biocide activity of hydrogel. Here in this study, hydrogels loaded CaCO3-Ag were prepared using poly (N-vinyl-2-pyrrolidone), poly (ethylene glycol), agar, calcium carbonate, silver nitrate followed gamma irradiation with 25 kGy dose. The gel fraction, behavior swelling and biocide action against P. aeruginosa was investigated. The degree of swelling of the hydrogel loaded CaCO3-Ag was 12% higher than the unloaded and exhibited antibacterial effects against P. aeruginosa and biofilm.


Hydrogel Calcium carbonate Eggshell Silver Bacteria 



The authors would like to thank Coordination for the Improvement of Higher Education Personnel (CAPES, process n° 88881.134341/2016-01), Foundation for Research Support of the State of São Paulo (FAPESP, process n° 2016/19254-0), and Nuclear and Energy Research Institute (IPEN-CNEN/SP, Brazil). Dr. T. Samuel Lab is supported by NIH SC3GM109314.


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Copyright information

© The Minerals, Metals & Materials Society 2019

Authors and Affiliations

  • Angelica Tamiao Zafalon
    • 1
    Email author
  • Vinícius dos Santos Juvino
    • 1
  • Luiz Gustavo Hiroki Komatsu
    • 1
  • Duclerc Fernandes Parra
    • 1
  • Ademar Lugao
    • 1
  • Temesgen Samuel
    • 2
  • Vijaya Rangari
    • 3
  1. 1.Nuclear and Energy Research Institute, IPEN, CNEN/SPSão PauloBrazil
  2. 2.College of Veterinary MedicineTuskegee UniversityTuskegeeUSA
  3. 3.Department of Materials Science and EngineeringTuskegee UniversityTuskegeeUSA

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