Microwave-Assisted Solid-State Synthesis of Fluorinated Hydroxyapatite

  • Qian Peng
  • Huimin Tang
  • Zhangui TangEmail author
  • Zhiwei PengEmail author
Conference paper
Part of the The Minerals, Metals & Materials Series book series (MMMS)


As an important inorganic component of vertebrate bones and teeth, hydroxyapatite (HA) has excellent biocompatibility, bioactivity, osteoconductivity and chemical stability, and can be used as a drug-release carrier and bone tissue engineering repair material. However, when it is used alone, it often presents a few disadvantages such as large brittleness, low fatigue resistance, and easy agglomeration. In this study, to improve its mechanical properties fluorinated hydroxyapatite (FHA) was synthesized by doping fluorine ion in nanocrystalline HA in solid state through microwave sintering of the mixture of HA and MgF2 in the presence of water as an adhesive agent. The X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FTIR) analyses were performed to explore the formation mechanism of FHA from HA under microwave irradiation.


Hydroxyapatite Fluorination Microwave sintering Synthesis Mechanical properties 



This work was partially supported by the Fundamental Research Funds for the Central Universities of Central South University under Grant 2018zzts040, the Co-Innovation Center for Clean and Efficient Utilization of Strategic Metal Mineral Resources under Grant 2014-405, the Innovation-Driven Program of Central South University under Grant 2016CXS021, and the Shenghua Lieying Program of Central South University under Grant 502035001.


  1. 1.
    Descamps M, Boilet L, Moreau G, Tricoteaux A, Lu J, Leriche A, Lardot V, Cambier F (2013) Processing and properties of biphasic calcium phosphates bioceramics obtained by pressureless sintering and hot isostatic pressing. J Eur Ceram Soc 33:1263–1270CrossRefGoogle Scholar
  2. 2.
    Calafiori AR, Di Marco G, Martino G, Marotta M (2007) Preparation and characterization of calcium phosphate biomaterials. J Mater Sci Mater Med 18:2331–2338CrossRefGoogle Scholar
  3. 3.
    Cengiz B, Gokce Y, Yildiz N, Aktas Z, Calimli A (2008) Synthesis and characterization of hydroxyapatite nanoparticles. Colloids Surf A Physicochem Eng Asp 322:29–33CrossRefGoogle Scholar
  4. 4.
    Catledge SA, Fries MD, Vohra YK, Lacefield WR, Lemons JE, Woodard S, Venugopalan R, Nanosci J (2002) Nanostructured ceramics for biomedical implants. J Nanosci Nanotechnol 2:293–312CrossRefGoogle Scholar
  5. 5.
    Dumbleton J, Manley MT (2004) Hydroxyapatite-coated prostheses in total hip and knee arthroplasty. J Bone Joint Surg Am 86A:2526–2540CrossRefGoogle Scholar
  6. 6.
    Rodríguez-Lorenzo LM, Hart JN, Gross KA (2003) Influence of fluorine in the synthesis of solid solutions of hydroxy-fluorapatite. Biomaterials 24(21):3777–3785CrossRefGoogle Scholar
  7. 7.
    Šupová M (2015) Substituted hydroxyapatites for biomedical applications: A review. Ceram Int 41(8):9203–9231CrossRefGoogle Scholar
  8. 8.
    Kim SR, Riu DH, Lee YJ, Jung SJ (2001) Synthesis and characterization of silicon substituted hydroxyapatite. J Kor Ceram Soc 38(12):1132–1136Google Scholar
  9. 9.
    Mayer I, Scblam R (1997) Magnesium-containing carbonate apatites. ElsevierGoogle Scholar
  10. 10.
    Chanda A, Dasgupta S, Bose S, Bandyopadhyay A (2009) Microwave sintering of calcium phosphate ceramics. Mater Sci Eng C 29:1144–1149CrossRefGoogle Scholar
  11. 11.
    Oghbaei M, Mirzaee O (2010) Microwave versus conventional sintering: a review of fundamentals, advantages and applications. J Alloy Comp 494:175–189CrossRefGoogle Scholar
  12. 12.
    Das S, Mukhopadhyay AK, Datta S, Basu D (2009) Prospects of microwave processing: an overview. B Mater Sci 32:1–13CrossRefGoogle Scholar
  13. 13.
    Peng Z, Hwang J (2015) Microwave-assisted metallurgy. Int Mater Rev 60:30–63CrossRefGoogle Scholar
  14. 14.
    Li B, Chen XN, Guo B, Wang XL, Fan HS, Zhang XD (2009) Fabrication and cellular biocompatibility of porous carbonated biphasic calcium phosphate ceramics with a nanostructure. Acta Biomater 5:134–143CrossRefGoogle Scholar
  15. 15.
    Cullity BD (1977) Elements of X-ray diffraction. Addison-Wesley PublishingGoogle Scholar
  16. 16.
    Ebrahimi-Kahrizsangi R, Nasiri-Tabrizi B, Chami A (2011) Characterization of single-crystal fluorapatite nanoparticles synthesized via mechanochemical method. Particuology 9:537–544CrossRefGoogle Scholar
  17. 17.
    Sun Y, Yang H, Tao D (2012) Preparation and characterization of Eu3+ -doped fluorapatite nanoparticles by a hydrothermal method. Ceram Int 38:6937–6941CrossRefGoogle Scholar
  18. 18.
    Roche KJ, Stanton KT (2014) Measurement of fluoride substitution in precipitated fluorhydroxyapatite nanoparticles. J Fluor Chem 161:102–109CrossRefGoogle Scholar
  19. 19.
    Karimi M, Ramsheh MR, Ahmadi SM, Madani MR, Shamsi M, Reshadi R, Farahnaz L (2017) Reline-assisted green and facile synthesis of fluorapatite nanoparticles. Mater Sci Eng C 77:121–128CrossRefGoogle Scholar
  20. 20.
    Geetha M, Singh AK, Asokamani R, Gogia AK (2009) Ti based biomaterials, the ultimate choice for orthopaedic implants-A review. Prog Mater Sci 54:397–425CrossRefGoogle Scholar

Copyright information

© The Minerals, Metals & Materials Society 2019

Authors and Affiliations

  1. 1.Xiangya Stomatological Hospital, Central South UniversityChangshaChina
  2. 2.School of Xiangya StomatologyCentral South UniversityChangshaChina
  3. 3.School of Minerals Processing and BioengineeringCentral South UniversityChangshaChina

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