Skip to main content

Endocrine Care of Transgender Children and Adolescents

  • Chapter
  • First Online:

Part of the book series: Contemporary Endocrinology ((COE))

Abstract

The medical approach to transgender children and adolescents is outlined by the World Professional Association for Transgender Health and the Endocrine Society. All treatment considerations must be guided by careful assessment for the diagnosis of gender dysphoria by a mental health professional with experience in gender identity and working with youth. Prior to the start of puberty, no medical intervention is required. Medical interventions in pubertal youth are aimed at suppressing the development of the secondary sex characteristics of the natal sex and promoting the development of secondary sex characteristics of the affirmed sex. Suppression of puberty using gonadotropin-releasing hormone agonists can be considered at Tanner stage 2. Initiation of gender-affirming hormones (testosterone or estrogen) has historically been considered at age 16, however, contemporary practice is trending to use patient and family readiness factors as opposed to an age restriction.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Herman JL, Flores AR, Brown TNT, Wilson B. DM, Conron K. Age of individuals who identify as transgender in the United States. The Williams Institute; 2017.

    Google Scholar 

  2. Hsieh S, Leininger J. Resource list: clinical care programs for gender-nonconforming children and adolescents. Pediatr Ann. 2014;43:238–44.

    Article  Google Scholar 

  3. Delemarre-van de Wall HA, Cohen-Kettenis PT. Clinical management of gender identity disorder in adolescents: a protocol on psychological and paediatric endocrinology aspects. Eur J Endocrinol. 2006;155:S131–7.

    Article  Google Scholar 

  4. Coleman E, et al. Standards of care for the health of transsexual, transgender, and gender-nonconforming people, version 7. Int J Transgenderism. 2012;13:165–232.

    Article  Google Scholar 

  5. Hembree WC, et al. Endocrine treatment of gender-dysphoric/gender-incongruent persons: an endocrine society* clinical practice guideline. J Clin Endocrinol Metab. 2017;102:1–35.

    Article  Google Scholar 

  6. Center of Excellence for Transgender Health. Guidelines for the primary and gender-affirming care of transgender and gender nonbinary people. University of California San Fransisco. http://transhealth.ucsf.edu/trans?page=guidelines-home. Accessed 3/19/2018.

  7. Rosenthal SM. Approach to the patient: transgender youth: endocrine considerations. J Clin Endocrinol Metab. 2014;99:4379–89.

    Article  CAS  Google Scholar 

  8. Simons L, Leibowitz SF, Hidalgo M. Understanding gender variance in children and adolescents. Pediatr Ann. 2014;43:e126–31.

    Article  Google Scholar 

  9. Shumer DE, Nokoff NJ, Spack NP. Advances in the care of transgender children and adolescents. Adv Pediatr. 2016;63:79–102.

    Article  Google Scholar 

  10. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed.; 2013.

    Google Scholar 

  11. Witchel SF, Lee PA. In: Sperling M, editor. A Pediatric endocrinology. Saunders Elsevier; 2008, p. 132.

    Google Scholar 

  12. Hughes, I. A. In: Sperling MA, editor. Pediatric endocrinology. Saunders Elsevier; 2008, p. 676–679.

    Google Scholar 

  13. Rosenfield RL, Cooke DW, Radovick S. In: Sperling MA, editor. Pediatric endocrinology. Saunders Elsevier; 2008, p. 532–559.

    Google Scholar 

  14. Marshal WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child. 1970;45:13–23.

    Article  Google Scholar 

  15. Marshall W, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child. 1969;44:291–303.

    Article  CAS  Google Scholar 

  16. Marcell, A. V. In: Kligman RM, Behrman RE, Jenson HB, Stanton BF, editors. Nelson textbook of pediatrics. Saunders Elsevier; 2007, p. 60–65.

    Google Scholar 

  17. Steensma TD, Biemond R, de Boer F, Cohen-Kettenis PT. Desisting and persisting gender dysphoria after childhood: a qualitative follow-up study. Clin Child Psychol Psychiatry. 2011.

    Google Scholar 

  18. Steensma T, Kreukels B, de Vries A, Cohen-Kettenis P. Gender identity development in adolescence. Horm Behav. 2013;64:288–97.

    Article  Google Scholar 

  19. Cohen-Kettenis PT, Klink D. Adolescents with gender dysphoria. Best Pract Res Clin Endocrinol Metab. 2015;29:485–95.

    Article  Google Scholar 

  20. Cohen-Kettenis PT, Delemarre-van de Wall HA, Gooren LJG. The treatment of adolescent transsexuals: changing insights. J Sex Med. 2008;5:1892–7.

    Article  Google Scholar 

  21. De Vries ALC, et al. Young adult psychological outcome after puberty suppression and gender reassignment. Pediatrics. 2014;134:1–9.

    Article  Google Scholar 

  22. De Vries ALC, Cohen-Kettenis PT. Clinical management of gender dysphoria in children and adolescents: the Dutch approach. J Homosex. 2012;59:301–20.

    Article  Google Scholar 

  23. Nahata L, Quinn GP, Caltabellotta N, Tishelman A. Mental health concerns and insurance denials among transgender adolescents. LGBT Heal. 2017;4:188–193.

    Article  Google Scholar 

  24. Veale J, Watson R, Peter T, Saewyc E. Mental health disparities among canadian transgender youth. J. Adolesc. Heal. 2017;60:44–9.

    Article  Google Scholar 

  25. Spack NP, et al. Children and adolescents with gender identity disorder referred to a pediatric medical center. Pediatrics. 2012;129:418–25.

    Article  Google Scholar 

  26. Boepple PA, et al. Use of a potent, long acting agonist of gonadotropin-releasing hormone in the treatment of precocious puberty. Endocr Rev. 1986;7:24–33.

    Article  CAS  Google Scholar 

  27. Chen M, Fuqua J. Adolescent transgender health: Awareness does not equal resources. Curr Pediatr Rep. 2016;4:186–7.

    Article  Google Scholar 

  28. Lynch MM, Khandheria MM, Meyer WJ. Retrospective study of the management of childhood and adolescent gender identity disorder using medroxyprogesterone acetate. Int. J. Transgenderism. 2015;16:201–8.

    Article  Google Scholar 

  29. Warren M, Mathews J, Morishima A, Vande Wiele R. The effect of medroxyprogesterone acetate on gonadotropin secretion in girls with precocious puberty. Am J Med Sci. 1975;269:375–81.

    Article  CAS  Google Scholar 

  30. Shumer DE, Spack NP. Current management of gender identity disorder in childhood and adolescence: guidelines, barriers and areas of controversy. Curr Opin Endocrinol Diabetes Obes. 2013;20:69–73.

    Article  CAS  Google Scholar 

  31. Spratt D, et al. Subcutaneous injection of testosterone is an effective and preferred alternative to intramuscular injection: demonstration in female-to-male transgender patients. J Clin Endocrinol Metab2. 2017;102:2349–55.

    Article  Google Scholar 

  32. Asscheman H, et al. A long-term follow-up study of mortality in transsexuals receiving treatment with cross-sex hormones. Eur J Endocrinol. 2011;164:635–42.

    Article  CAS  Google Scholar 

  33. Vlot M, et al. Effect of pubertal suppression and cross-sex hormone therapy on bone turnover markers and bone mineral apparent density (BMAD) in transgender adolescents. Bone. 2017;95:11–9.

    Article  CAS  Google Scholar 

  34. Klink D, Caris M, Heijboer A, van Trotsenburg M, Rotteveel J. Bone mass in young adulthood following gonadotropin-releasing hormone analog treatment and cross-sex hormone treatment in adolescents with gender dysphoria. J Clin Endocrinol Metab. 2015;100:E270–5.

    Article  CAS  Google Scholar 

  35. Wierckx K, et al. Reproductive wish in transsexual men. Hum Reprod2. 2012;27:483–7.

    Article  Google Scholar 

  36. Pasquino A, et al. Long-term observation of 87 girls with idiopathic central precocious puberty treated with gonadotropin-releasing hormone analogs: impact on adult height, body mass index, bone mineral content, and reproductive function. J Clin Endocrinol Metab. 2008;93:190–5.

    Article  CAS  Google Scholar 

  37. Nahata L, Curci M, Quinn G. Exploring fertility preservation intentions among transgender youth. J Adolesc Heal. 2018;62:123–5.

    Article  Google Scholar 

  38. American Academy of Pediatrics Committee on Bioethics. Informed consent, parental permission, and assent in pediatric practice. Pediatrics. 1995:314–317.

    Google Scholar 

  39. Shumer D, Tishelman A. The role of assent in the treatment of transgender adolescents. Int J Transgenderism. https://doi.org/10.1080/15532739.2015.1075929.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Daniel Evan Shumer .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Shumer, D.E., Araya, A. (2019). Endocrine Care of Transgender Children and Adolescents. In: Poretsky, L., Hembree, W. (eds) Transgender Medicine. Contemporary Endocrinology. Humana Press, Cham. https://doi.org/10.1007/978-3-030-05683-4_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-05683-4_9

  • Published:

  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-030-05682-7

  • Online ISBN: 978-3-030-05683-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics