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Vitamin E in Human Health pp 99–109Cite as

Metabolomic Approaches in Vitamin E Research

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Part of the book series: Nutrition and Health ((NH))

Abstract

Metabolomics aims to characterise changes to the complement of metabolites in a biological sample (metabolome), and this technology is gaining interest in nutrition research as it can define perturbations to metabolism induced by dietary factors. There have been a number of metabolomic studies in human and animal models based around vitamin E supplementation or deficiency that have highlighted potential areas in metabolism that vitamin E may play a role. In humans, vitamin E supplementation has been shown to influence phospholipid metabolism and amino acid metabolism, and discriminatory metabolites have included several vitamin E metabolites. Proteomic studies looking at associations with vitamin E concentrations have demonstrated consistent relationships with several apoproteins. Metabolomic studies in animal models include studies on zebrafish foetal development that showed changes to antioxidant status and lipid peroxidation with vitamin E deficiency and rodent models of vitamin E deficiency that showed influences on central metabolism. Metabolomics has proven to be a useful research tool to identify novel functions of vitamin E.

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Author information

Authors and Affiliations

  1. Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK

    John K. Lodge

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  1. John K. Lodge
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Correspondence to John K. Lodge .

Editor information

Editors and Affiliations

  1. University of Hohenheim, Institute of Nutritional Sciences, Stuttgart , Germany

    Peter Weber

  2. University of Applied Sciences Fulda, Nutritional, Food and Consumer Sciences, Fulda, Germany

    Marc Birringer

  3. Friedman School of Nutrition Science and Policy, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA

    Jeffrey B. Blumberg

  4. University Medical Center Groningen, Hanzeplain 1, Groningen, The Netherlands

    Manfred Eggersdorfer

  5. University of Hohenheim, Institute of Nutritional Sciences, Stuttgart , Germany

    Jan Frank

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Lodge, J.K. (2019). Metabolomic Approaches in Vitamin E Research. In: Weber, P., Birringer, M., Blumberg, J., Eggersdorfer, M., Frank, J. (eds) Vitamin E in Human Health. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-030-05315-4_8

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  • DOI: https://doi.org/10.1007/978-3-030-05315-4_8

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  • Online ISBN: 978-3-030-05315-4

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