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Vitamin E-Drug Interactions

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Vitamin E in Human Health

Part of the book series: Nutrition and Health ((NH))

Abstract

Dietary vitamin E supplements, often containing high doses of vitamin E, are frequently consumed by people treated with one or more prescription drugs. Interactions of vitamin E with drugs therefore need to be considered. In this chapter, we introduce the basics of nutrient-drug interactions: interactions affecting the pharmacokinetics (the metabolism of a drug) or pharmacodynamics (the effect of a drug) of drugs. We then review the evidence in the scientific literature to assess the potential of all eight vitamin E congeners to interact with drugs. In summary, there is no evidence for vitamin E-drug interactions at vitamin E intakes achievable by diet. High-dose (≥300 mg/d) supplementation of vitamin E, especially of α-tocopherol, however, may lead to interactions with aspirin, warfarin, tamoxifen, and cyclosporine A. For the majority of drugs, interactions with vitamin E, even at high doses, have not been observed and are unlikely to occur.

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Authors and Affiliations

  1. Institute of Nutritional Sciences, University of Hohenheim, Stuttgart, Germany

    Maren C. Podszun & Jan Frank

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  1. Maren C. Podszun
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  2. Jan Frank
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Correspondence to Maren C. Podszun .

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Editors and Affiliations

  1. University of Hohenheim, Institute of Nutritional Sciences, Stuttgart , Germany

    Peter Weber

  2. University of Applied Sciences Fulda, Nutritional, Food and Consumer Sciences, Fulda, Germany

    Marc Birringer

  3. Friedman School of Nutrition Science and Policy, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA

    Jeffrey B. Blumberg

  4. University Medical Center Groningen, Hanzeplain 1, Groningen, The Netherlands

    Manfred Eggersdorfer

  5. University of Hohenheim, Institute of Nutritional Sciences, Stuttgart , Germany

    Jan Frank

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Podszun, M.C., Frank, J. (2019). Vitamin E-Drug Interactions. In: Weber, P., Birringer, M., Blumberg, J., Eggersdorfer, M., Frank, J. (eds) Vitamin E in Human Health. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-030-05315-4_18

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  • DOI: https://doi.org/10.1007/978-3-030-05315-4_18

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