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Cell-Based Therapy for Degenerative Retinal Disease pp 53–80Cite as

Degenerative Retinal Diseases: Cell Sources for Cell-Based Therapy

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

In the aggregate, retinal degenerative diseases such as age-related macular degeneration, retinitis pigmentosa, and Stargardt disease are major causes of vision loss and blindness worldwide. Damage to retinal pigment epithelial cells and photoreceptors eventually leads to their death, and, in contrast to some species such as zebrafish, humans lack an endogenous system for robust spontaneous replacement or repair. Cell-based therapies provide a rational option to restore function, particularly when there is substantial loss of neuronal tissue. A number of important issues remain unresolved, however, including the differentiation and integration of cells after implantation. For stem cell therapies, the retina provides an excellent environment, not only because of its ease of access for surgical procedures but also because of the ability to observe transplanted cells directly through clear ocular media using innovative imaging approaches. The improvements in the clinical use of progenitor cells in the last decade have resulted in significant advances for the treatment of degenerative retinal disease. In this chapter, a brief discussion is given of the main sources of stem cells used for photoreceptor and/or retinal pigment epithelium recovery/replacement.

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Acknowledgments

The authors are grateful for the support by grants from Fondos de Investigaciones Sanitarias del Instituto Carlos III (FIS10-PI040654 and FIS14-PI00196) and Fundació Marató TV3 (20120630-30-31). The research project was co-financed by the European Regional Development Fund (FEDER) of European Union.

Disclosure of Potential Conflicts of Interest: None. The authors report no financial or conflicts of interest.

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Authors and Affiliations

  1. Department of Surgery, School of Medicine & Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain

    Ricardo P. Casaroli-Marano

  2. Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Barcelona Tissue Bank (BST), Barcelona, Spain

    Ricardo P. Casaroli-Marano

  3. Barcelona Tissue Bank (BST), Institute of Biomedical Research Sant Pau (IIB-Sant Pau), Barcelona, Spain

    Núria Nieto-Nicolau

  4. CellTec-UB, University of Barcelona, Barcelona, Spain

    Raquel A. Martínez-García de la Torre

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  1. Ricardo P. Casaroli-Marano
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  2. Núria Nieto-Nicolau
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Correspondence to Ricardo P. Casaroli-Marano .

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Editors and Affiliations

  1. Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, NJ, USA

    Marco A. Zarbin

  2. Wilmer Eye Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA

    Mandeep S. Singh

  3. Department of Surgery School of Medicine & Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain

    Ricardo P. Casaroli-Marano

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Casaroli-Marano, R.P., Nieto-Nicolau, N., Martínez-García de la Torre, R.A. (2019). Degenerative Retinal Diseases: Cell Sources for Cell-Based Therapy. In: Zarbin, M., Singh, M., Casaroli-Marano, R. (eds) Cell-Based Therapy for Degenerative Retinal Disease . Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-030-05222-5_4

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