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Avian Pathogenic Escherichia coli: Link to Foodborne Urinary Tract Infections in Humans

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Food Safety in Poultry Meat Production

Part of the book series: Food Microbiology and Food Safety ((PRACT))

Abstract

Urinary tract infections (UTIs) caused by Escherichia coli are a serious societal and public health concern owing to the resultant morbidity, productivity loss, and healthcare costs. The increasing prevalence of UTIs caused by multidrug-resistant (MDR) E. coli combined with the dearth of effective preventative measures, such as vaccines, has kept UTIs on the radar of scientists, public health officials, and physicians. Historically, UTIs were viewed as individual, isolated infections caused by bacteria from the patient’s intrinsic endogenous intestinal flora; however, recent data suggest that the pathogenesis of some UTIs is due to a foodborne origin. The prevalence of UTIs caused by MDR strains of E. coli is increasingly reported from many countries. In parallel, MDR E. coli with urovirulence properties and some uropathogenic E. coli (UPEC) lineages have been isolated from poultry and poultry meat indicating possible zoonotic transmission of avian pathogenic E. coli (APEC) with poultry serving as a reservoir for UPEC. Considering the public health implications and societal burden presented by UTIs, the proposed poultry reservoir for UPEC merits thorough investigation. This chapter discusses a potential foodborne link between APEC and UTIs in humans, providing general knowledge on extraintestinal pathogenic E. coli in general, and then UPEC, APEC, and retail poultry E. coli, separately, followed by the present state of understanding of APEC as a cause of foodborne UTI.

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Authors and Affiliations

  1. Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA

    Subhashinie Kariyawasam

  2. Department of Medicine Senior Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Jennifer Han

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Correspondence to Subhashinie Kariyawasam .

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  1. Department of Animal Science, University of Connecticut, Storrs, CT, USA

    Kumar Venkitanarayanan

  2. College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA

    Siddhartha Thakur

  3. Department of Food Science, University of Arkansas, Fayetteville, AR, USA

    Steven C. Ricke

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Kariyawasam, S., Han, J. (2019). Avian Pathogenic Escherichia coli: Link to Foodborne Urinary Tract Infections in Humans. In: Venkitanarayanan, K., Thakur, S., Ricke, S. (eds) Food Safety in Poultry Meat Production. Food Microbiology and Food Safety(). Springer, Cham. https://doi.org/10.1007/978-3-030-05011-5_12

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