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Nutraceuticals in Reproductive Disorders

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Nutraceuticals in Veterinary Medicine

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Abstract

Reproductive disorders or abnormalities that occur in male and female reproductive tracts are induced by infectious and noninfectious agents and various other conditions. In the contemporary world, common use of synthetic chemicals in cosmetics and other items for domestic day-to-day uses undoubtedly contributes to the noninfectious causes of reproductive abnormalities. In both animals and humans, modern drugs are used to treat reproductive disorders. However, unwanted side effects that follow often pose severe problems and concerns, consequently increasing global use of natural products including nutraceuticals to treat reproductive abnormalities. In this chapter, the use of nutraceuticals in the treatment and management of female and male reproductive tract abnormalities is briefly highlighted.

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References

  • Akhtar MS, Hossain MA, Said SA (2017) Isolation and characterization of antimicrobial compound from the stem-bark of the traditionally used medicinal plant, Adenium obesum. J Tradit Complement Med 7(2017):296e300

    Google Scholar 

  • Anywar G, Oryem-Origa H, Kamatenesi-Mugisha M (2014) Antibacterial and antifungal properties of some wild nutraceutical plant species from Nebbi District, Uganda. Br J Pharm Res 4(14):1753–1761

    Article  Google Scholar 

  • Áyen Á, Jiménez Martínez Y, Marchal JA et al (2018) Recent progress in gene therapy for ovarian cancer. Int J Mol Sci 19(7):E1930. https://doi.org/10.3390/ijms19071930

    Article  CAS  PubMed  Google Scholar 

  • Bagheri A, Nachvak SM, Rezaei M et al (2018) Dietary patterns and risk of prostate cancer: a factor analysis study in a sample of Iranian men. Health Promot Perspect 8(2):133–138

    Article  Google Scholar 

  • Banerjee N, Talcott S, Safe S et al (2012) Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation. Breast Cancer Res Treat 136:21–34

    Article  CAS  Google Scholar 

  • Bonde JP (2010) Male reproductive organs are at risk from environmental Hazards. A review. Asian J Androl 12:152–156

    Article  CAS  Google Scholar 

  • Bradlow HL (2008) Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer. In Vivo 22:441–445

    CAS  PubMed  Google Scholar 

  • Butalla AC, Crane TE, Patil B et al (2012) Effects of a carrot juice intervention on plasma carotenoids, oxidative stress, and inflammation in overweight breast cancer survivors. Nutr Cancer 64:331–341

    Article  CAS  Google Scholar 

  • Chauhan B, Kumar G, Kalam N et al (2013) Current concepts and prospects of herbal nutraceutical: a review. J Adv Pharm Technol Res 4:4–8

    Article  CAS  Google Scholar 

  • Chung KS, Shin SJ, Lee NY et al (2016) Anti-proliferation effects of garlic (Allium sativum L.) on the progression of benign prostatic hyperplasia. Phytother Res 30(7):1197–1203

    Article  CAS  Google Scholar 

  • De Franciscis P, Grauso F, Luisi A et al (2017) Adding Agnus Castus and Magnolia to soy isoflavones relieves sleep disturbances besides postmenopausal vasomotor symptoms long-term safety and effectiveness. Nutrients 9:129. https://doi.org/10.3390/nu9020129

    Article  CAS  PubMed Central  Google Scholar 

  • Egnell M, Fassier P, Lécuyer L et al (2017) B-Vitamin intake from diet and supplements and breast cancer risk in middle-aged women: results from the prospective NutriNet-Santé cohort. Nutrients 9:488. https://doi.org/10.3390/nu9050488

    Article  CAS  PubMed Central  Google Scholar 

  • Fadus MC, Lau C, Bikhchandani J et al (2017) Curcumin: an age-old anti-inflammatory and anti-neoplastic agent. J Tradit Complement Med 7(2017):339e346

    Google Scholar 

  • Fu Y, Chang H, Peng X et al (2014) Resveratrol inhibits breast cancer stem-like cells and induces autophagy via suppressing Wnt/β-catenin signaling pathway. PLoS One 9:e102535. https://doi.org/10.1371/journal.pone.0102535

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hemingway RG (2003) The influences of dietary intakes and supplementation with selenium and vitamin-E on reproduction diseases and reproductive efficiency in cattle and sheep. Vet Res Commun 27(2):159–174

    Article  CAS  Google Scholar 

  • Hong SA, Kim K, Nam SJ et al (2008) A case-control study on the dietary intake of mushrooms and breast cancer risk among Korean women. Int J Cancer 122:919–923

    Article  CAS  Google Scholar 

  • Hussain A, Sharma C, Khan S et al (2015) Aloe vera inhibits proliferation of human breast and cervical cancer cells and acts synergistically with cisplatin. Asian Pac J Cancer Prev 16(7):2939–2946

    Article  Google Scholar 

  • Imanshahidi M, Hosseinzadeh H (2008) Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother Res 22(8):999–1012

    Article  CAS  Google Scholar 

  • Joo JH, Hong SS, Cho YR et al (2016) 10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38(MAPK) activity. Oncol Rep 35:779–784

    Article  CAS  Google Scholar 

  • Kalra EK (2003) Nutraceutical-definition and introduction. AAPS PharmSci 5:E25. https://doi.org/10.1208/ps050325

    Article  PubMed  Google Scholar 

  • Kim JH, Woo J-H, Kim HM et al (2017) Anti-endometriotic effects of Pueraria flower extract in human endometriotic cells and mice. Nutrients 9:212. https://doi.org/10.3390/nu9030212

    Article  CAS  PubMed Central  Google Scholar 

  • Larussa T, Imeneo M, Luzza F (2017) Potential role of nutraceutical compounds in inflammatory bowel disease. World J Gastroenterol 23(14):2483–2492

    Article  CAS  Google Scholar 

  • Lee HS, Seo EY, Kang NE et al (2008) (6)-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. J Nutr Biochem 19:313–319

    Article  CAS  Google Scholar 

  • Li JY, Zou L, Chen W et al (2014) Dietary mushroom intake may reduce the risk of breast cancer: Evidence from a meta-analysis of observational studies. PLoS One 9:e93437

    Article  Google Scholar 

  • Li Y, Li S, Meng X et al (2017) Dietary natural products for prevention and treatment of breast cancer. Nutrients 9:728. https://doi.org/10.3390/nu9070728

    Article  CAS  PubMed Central  Google Scholar 

  • Lodi A, Saha A, Lu X et al (2017) Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism. NPJ Precis Oncol 1:18. https://doi.org/10.1038/s41698-017-0024-z

    Article  PubMed  PubMed Central  Google Scholar 

  • Mandal A, Bhatia D, Bishayee A (2017) Anti-inflammatory mechanism involved in pomegranate-mediated prevention of breast cancer: the role of NF-кB and Nrf2 signaling pathways. Nutrients 9:436. https://doi.org/10.3390/nu9050436

    Article  CAS  PubMed Central  Google Scholar 

  • McCubrey JA, Lertpiriyapong K, Steelman LS et al (2017) Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs. Aging 9(6):1477–1536

    Article  CAS  Google Scholar 

  • Mehta R, Lansky EP (2004) Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture. Eur J Cancer Prev 13:345–348

    Article  CAS  Google Scholar 

  • Patel K, Patel DK (2017) Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: a concise report. J Trad Complem Med 7(2017):360e366

    Google Scholar 

  • Sayeed B, Ameen SS (2015) Beta-sitosterol: a promising but orphan nutraceutical to fight against cancer. Nutr Cancer 67(8):1214–1220

    Google Scholar 

  • Schneider-Stock R, Fakhoury IH, Zaki AM et al (2014) Thymoquinone: fifty years of success in the battle against cancer models. Drug Discov Today 19:18–30

    Article  CAS  Google Scholar 

  • Siegel RL, Miller KD, Jemal A (2016) Cancer statistics, 2016. CA Cancer J Clin 66:7–30

    Article  Google Scholar 

  • Song X, Li Z, Ji X et al (2017) Review: calcium intake and the risk of ovarian cancer: a meta-analysis. Nutrients 9:679. https://doi.org/10.3390/nu9070679

    Article  CAS  PubMed Central  Google Scholar 

  • Thomson CA, Ho E, Strom MB (2016) Chemopreventive properties of 3,30-diindolylmethane in breast cancer: evidence from experimental and human studies. Nutr Rev 74:432–443

    Article  Google Scholar 

  • Tsuji PA, Carlson BA, Anderson CB et al (2015) Dietary selenium levels affect selenoprotein expression and support the interferon- and IL-6 immune response pathways in mice. Nutrients 7:6529–6549. https://doi.org/10.3390/nu7085297

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vahlensieck W, Theurer C, Pfitzer E et al (2015) Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 94(3):286–295

    Article  CAS  Google Scholar 

  • Wu HL, Chuang TY, Al-Hendy A et al (2015) Berberine inhibits the proliferation of human uterine leiomyoma cells. Fertil Steril 103:1098–1106

    Article  CAS  Google Scholar 

  • Xie Q, Chen ML, Qin Y et al (2013) Isoflavone consumption and risk of breast cancer: a dose-response meta-analysis of observational studies. Asia Pac J Clin Nutr 22:118–127

    CAS  PubMed  Google Scholar 

  • Yung MM, Ross FA, Hardie DG et al (2016) Bitter melon (Momordica charantia) extract inhibits tumorigenicity and overcomes cisplatin-resistance in ovarian cancer cells through targeting AMPK signaling cascade. Integr Cancer Ther 15:376–389

    Article  CAS  Google Scholar 

  • Zardast M, Namakin K, KahoJ E et al (2016) Assessment of antibacterial effect of garlic in patients infected with Helicobacter pylori: assessment of garlic’s effect using urease breath test. Avicenna J Phytomed 6(5):495–501

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zhao Y, Jing Z, Lv J et al (2017) Berberine activates caspase-9/cytochrome c-mediated apoptosis to suppress triple-negative breast cancer cells in vitro and in vivo. Biomed Pharmacother 95:18–24

    Article  CAS  Google Scholar 

  • Zhou Q, Ye M, Lu Y et al (2015) Curcumin improves the tumoricidal effect of mitomycin C by suppressing ABCG2 expression in stem cell-like breast cancer cells. PLoS One 10:e0136694. https://doi.org/10.1371/journal.pone.0136694

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Tifton Veterinary Diagnostic and Investigational Laboratory, Department of Pathology, College of Veterinary Medicine, University of Georgia, Tifton, GA, USA

    Moges Woldemeskel

Authors
  1. Moges Woldemeskel
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Correspondence to Moges Woldemeskel .

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Editors and Affiliations

  1. Department of Toxicology, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA

    Ramesh C. Gupta

  2. Vets Plus Inc., University of Wisconsin–Stout, Menonomie, WI, USA

    Ajay Srivastava

  3. Vets Plus Inc., Menomonie, WI, USA

    Rajiv Lall

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Woldemeskel, M. (2019). Nutraceuticals in Reproductive Disorders. In: Gupta, R., Srivastava, A., Lall, R. (eds) Nutraceuticals in Veterinary Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-04624-8_32

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