Skip to main content

Fenugreek in Health and Disease

  • Chapter
  • First Online:

Abstract

Fenugreek is an herb which has been used in traditional medicines for centuries in wound healing, as an aphrodisiac, for promotion of lactation, etc. The consumption of the seeds as a spice results in different medicinal effects such as hypocholesterolemic, antidiabetic, hepatoprotective, antibacterial, anthelmintic, anticancer, and galactogogue. Flavonoids, saponins, pyridine alkaloids, and steroidal sapogenins are some of the phytochemicals present in the plant. The plant is also embraced for its high content of important vitamins, minerals, protein and amino acids, and fibers making it a nutritious fodder for livestock. Extracts of the leaves and seeds of fenugreek are considered safe and are found to have potential therapeutic explicabilities in the treatment and/or management of diabetes, cancer, toxicities, cardiovascular diseases, physical injuries, and hormonal imbalances. The seeds and leaves of this plant are now being incorporated into animal, bird, and fish foods to increase feed intake, to promote weight gain, and to decrease the feed conversion ratio. The addition of fenugreek in the drinking water of poultry reduces stress, and this can be an important strategy to replace the use of antibiotics such as enrofloxacin as an anti-stress agent, and thus the issues of antibiotic residues in meat, as well as widely developing antibiotic resistance, would be less.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   299.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   379.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Abdel-Barry JA, Abdel-Hassan IA, Al-Hakiem MH (1997) Hypoglycemic and antihyperglycemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats. J Ethnopharmacol 58(3):149–155

    Article  CAS  PubMed  Google Scholar 

  • Acharya SN, Basu SK, Thomas JE (2007) Medicinal properties of fenugreek (Trigonella foenum-graecum L.): a review of the evidence based information. Adv Med Plant Res:81–122

    Google Scholar 

  • Adil S, Qureshi S, Pattoo RA (2015) A review on positive effects of fenugreek as feed additive in poultry production. Int J Poult Sci 14(12):664–669

    Article  CAS  Google Scholar 

  • Ahmad A, Alghamdi SS, Mahmood K et al (2016) Fenugreek a multipurpose crop: potentialities and improvements. Saudi J Biol Sci 23(2):300–310

    Article  PubMed  Google Scholar 

  • Ahmed SI, Hayat MQ, Zahid S et al (2017) Isolation and identification of flavonoids from anticancer and neuroprotective extracts of Trigonella foenum graecum. Trop J Pharm Res 16(6):1391–1398

    Article  CAS  Google Scholar 

  • Ajabnoor MA, Tilmisany AK (1988) Effect of Trigonella foenum graceum on blood glucose levels in normal and alloxan-diabetic mice. J Ethnopharmacol 22(1):45–49

    Article  CAS  PubMed  Google Scholar 

  • Alloui N, Aksa SB, Alloui MN et al (2012) Utilization of fenugreek (Trigonella foenum-graecum) as growth promoter for broiler chickens. J World Poult Res 2(2):25–27

    Google Scholar 

  • Alsemari A, Alkhodairy F, Aldakan A et al (2014) The selective cytotoxic anti-cancer properties and proteomic analysis of Trigonella foenum-graecum. BMC Complement Altern Med 14(1):114

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Altuntaş E, Özgöz E, Taşer ÖF (2005) Some physical properties of fenugreek (Trigonella foenum-graceum L.) seeds. J Food Eng 71(1):37–43

    Article  Google Scholar 

  • Anarthe SJ, Sunitha D, Raju MG (2014) Immunomodulatory activity for methanolic extract of Trigonella foenum graecum whole plant in wistar albino rats. Am J Phytomed Clin Ther 2(9):1081–1092

    Google Scholar 

  • Association of Official Analytical Chemists (A.O.A.C) (1990) Official methods of analysis, 15th edn. Association of Official Analytical Chemists, Washington, DC

    Google Scholar 

  • Barik NK (2017) Freshwater fish for nutrition security in India: evidence from FAO data. Aquacult Rep 7:1–6

    Article  Google Scholar 

  • Beaud D, Tailliez P, Anba-Mondoloni J (2005) Genetic characterization of the β-glucuronidase enzyme from a human intestinal bacterium, Ruminococcus gnavus. Microbiology 151(7):2323–2330

    Article  CAS  PubMed  Google Scholar 

  • Belaïd-Nouira Y, Bakhta H, Haouas Z et al (2013a) Fenugreek seeds, a hepatoprotector forage crop against chronic AlCl3 toxicity. BMC Vet Res 9(1):22

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Belaïd-Nouira Y, Bakhta H, Haouas Z et al (2013b) Fenugreek seeds reduce aluminum toxicity associated with renal failure in rats. Nutr Res Pract 7(6):466–474

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Benzie IF, Wachtel-Galor S (2011) Herbal medicine: biomolecular and clinical aspects, 2nd edn. CRC Press, Boca Raton, FL, p 410

    Book  Google Scholar 

  • Betty R (2008) The many healing virtues of fenugreek. Spice India 1:17–19

    Google Scholar 

  • Bhalke RD, Anarthe SJ, Sasane KD et al (2009) Antinociceptive activity of Trigonella foenum graecum leaves and seeds (Fabaceae). Int J Pharm Technol 8(2):57–59

    Google Scholar 

  • Bhat BG, Sambaia K, Chandrasekhara N (1985) The effect of feeding fenugreek and ginger on bile composition in the albino rats. Nutr Rep Int 32:1145–1151

    Google Scholar 

  • Bin-Hafeez B, Haque R, Parvez S et al (2003) Immunomodulatory effects of fenugreek (Trigonella foenum graecum L.) extract in mice. Int Immunopharmacol 3(2):257–265

    Article  CAS  PubMed  Google Scholar 

  • Boban PT, Nambisan B, Sudhakaran PR (2009) Dietary mucilage promotes regression of atheromatous lesions in hypercholesterolemic rabbits. Phytother Res 23(5):725–730

    Article  CAS  PubMed  Google Scholar 

  • Booupathy LK, Venkatachalam S, Natarajan N (2016) Chemopreventive effect of myrtenal on bacterial enzyme activity and the development of 1, 2-dimethyl hydrazine-induced aberrant crypt foci in Wistar rats. J Food Drug Anal 24(1):206–213

    Article  CAS  PubMed  Google Scholar 

  • Buchineni M, Kondaveti S (2016) In-vitro anthelmintic activity of fenugreek leaves (aqueous extract) in Indian earthworms. Pharm Innov J 5(4, Part B):70–72

    CAS  Google Scholar 

  • Chatterjee S, Variyar SP, Sharma A (2010) Bioactive lipid constituents of fenugreek. Food Chem 119(1):349–353

    Article  CAS  Google Scholar 

  • Chen X, Guo C, Kong J (2012) Oxidative stress in neurodegenerative diseases. Neural Regen Res 7(5):376–385

    CAS  PubMed  PubMed Central  Google Scholar 

  • Corey KE, Cohen DE (2015) Lipid and lipoprotein metabolism in liver disease. In: De Groot LJ, Chrousos G, Dungan K, et al. (ed) Endotext (Internet), MDText.com, Inc., South Dartmouth, MA, 2000-. (Updated 2015 Jun 27). Available from https://www.ncbi.nlm.nih.gov/books/NBK326742

  • Dangi R, Misar A, Tamhankar S, Rao S (2014) Diosgenin content in some Trigonella species. Indian J Adv Plant Res 1:47–51

    CAS  Google Scholar 

  • Degirmencioglu T, Unal H, Ozbilgin S et al (2016) Effect of ground fenugreek seeds (Trigonella foenum-graecum) on feed consumption and milk performance in Anatolian water buffaloes. Arch Anim Breed 59(3):345–349

    Article  Google Scholar 

  • Devasena T, Menon VP (2003) Fenugreek affects the activity of β-glucuronidase and mucinase in the colon. Phytother Res 17(9):1088–1091

    Article  CAS  PubMed  Google Scholar 

  • Dixit P, Ghaskadbi S, Mohan H et al (2005) Antioxidant properties of germinated fenugreek seeds. Phytother Res 19(11):977–983

    Article  CAS  PubMed  Google Scholar 

  • Dymock W, Warden CJH, Hooper D (2005) Pharmacographic indica. Srishti Book Distributors, New Delhi, pp 401–404

    Google Scholar 

  • Edison S (1995) Spices-research support to productivity. In: Ravi N (ed) The Hindu. survey of Indian agriculture. Kasturi and Sons Ltd., Madras, pp 101–105

    Google Scholar 

  • Elbushra ME (2012) Effect of dietary Fenugreek seeds (Trigonella foenum) as natural feed addition on broiler chicks performance. J Sci Technol 13:27–31

    Google Scholar 

  • El-Nor SAH, Khattab HM, Al-Alamy HA et al (2007) Effects of some medicinal plants seeds in the rations on the productive performance of lactating buffaloes. Int J Dairy Sci 2:348–355

    Article  Google Scholar 

  • El-Shayeb NMA, Mabrouk AM (1984) Utilization of some edible and medicinal plants to inhibit aflatoxin formation. Nutr Rep Int 29:273–282

    CAS  Google Scholar 

  • Figer B, Pissurlenkar R, Ambre P et al (2017) Treatment of gastric ulcers with fenugreek seed extract; In-Vitro, In-Vivo and In-Silico approaches. Indian J Pharm Sci 79(5):724–730

    Article  CAS  Google Scholar 

  • Francis G, Kerem Z, Makkar PS et al (2002) The biological action of saponins in animals systems: a review. Br J Nutr 88(6):587–605

    Article  CAS  PubMed  Google Scholar 

  • Ghafagaai T, Farid H, Pourafkari A (1980) In-vitro study of the anthelmintic action of Trigonella foenum graecum L. grown in Iran. Iran J Publ Health 9(1–4):21–26

    Google Scholar 

  • Gupta A, Gupta R, Lal B (2001) Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes. J Assoc Physicians India 49:1057–1061

    CAS  PubMed  Google Scholar 

  • Hamden K, Masmoudi H, Carreau S et al (2010) Immunomodulatory, β-cell, and neuroprotective actions of fenugreek oil from alloxan-induced diabetes. Immunopharmacol Immunotoxicol 32(3):437–445

    Article  PubMed  Google Scholar 

  • Haouala R, Hawala S, El-Ayeb A et al (2008) Aqueous and organic extracts of Trigonella foenum-graecum L. inhibit the mycelia growth of fungi. J Environ Sci (China) 20(12):1453–1457

    Article  CAS  Google Scholar 

  • Ismail A (2000) Effect of fenugreek seeds (Trigonella Foenum-graecum L.) as feed additive on sheep performance in the North Western coast of Egypt. In: Proc 3rd all Africa Conf. Anim. Agric. 811th Conf, Egyptian Soc. Anim. Prod. Alexandria, Egypt, pp 6–9

    Google Scholar 

  • Jin Y, Shi Y, Zou Y et al (2014) Fenugreek prevents the development of STZ-induced diabetic nephropathy in a rat model of diabetes. Evid Based Complement Alternat Med 2014. https://doi.org/10.1155/2014/259368

    Google Scholar 

  • Kagan BL, Selsted ME, Ganz T, Lehrer RI (1990) Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci 87(1):210–214

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kalailingam P, Kannaian B, Tamilmani E et al (2014) Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats. Phytomedicine 21(10):1154–1161

    Article  CAS  PubMed  Google Scholar 

  • Kalshetti PB, Alluri R, Mohan V et al (2015) Effects of 4-hydroxyisoleucine from fenugreek seeds on depression-like behavior in socially isolated olfactory bulbectomized rats. Pharmacogn Mag 11(Suppl 3):S388

    PubMed  PubMed Central  Google Scholar 

  • Kamboj SS, Chopra K, Sandhir R (2009) Hyperglycemia-induced alterations in synaptosomal membrane fluidity and activity of membrane bound enzymes: beneficial effect of N-acetylcysteine supplementation. Neuroscience 162(2):349–358

    Article  CAS  PubMed  Google Scholar 

  • Kanchan DM, Somani GS, Peshattiwar VV et al (2016) Renoprotective effect of diosgenin in streptozotocin induced diabetic rats. Pharmacol Rep 68(2):370–377

    Article  CAS  PubMed  Google Scholar 

  • Kandhare AD, Bodhankar SL, Mohan V et al (2015) Acute and repeated doses (28 days) oral toxicity study of glycosides based standardized fenugreek seed extract in laboratory mice. Regul Toxicol Pharmacol 72(2):323–334

    Article  CAS  PubMed  Google Scholar 

  • Kaviarasan S, Anuradha CV (2007) Fenugreek (Trigonella foenum graecum) seed polyphenols protect liver from alcohol toxicity: a role on hepatic detoxification system and apoptosis. Pharmazie 62(4):299–304

    CAS  PubMed  Google Scholar 

  • Kaviarasan S, Ramamurty N, Gunasekaran P et al (2006) Fenugreek (Trigonella foenum graecum) seed extract prevents ethanol-induced toxicity and apoptosis in Chang liver cells. Alcohol Alcohol 41(3):267–273

    Article  PubMed  Google Scholar 

  • Kaviarasan S, Naik GH, Gangabhagirathi R et al (2007) In-vitro studies on antiradical and antioxidant activities of fenugreek (Trigonella foenum graecum) seeds. Food Chem 103(1):31–37

    Article  CAS  Google Scholar 

  • Khader M, Eckl PM, Bresgen N (2007) Effects of aqueous extracts of medicinal plants on MNNG-treated rat hepatocytes in primary cultures. J Ethnopharmacol 112(1):199–202

    Article  CAS  PubMed  Google Scholar 

  • Khadse CD, Kakde RB (2010) In-vitro anthelmintic activity of Fenugreek seeds extract against Pheritima posthuma. Int J Res Pharm Sci 1(3):267–269

    Google Scholar 

  • Khorshidian N, Yousefi Asli M, Arab M et al (2016) Fenugreek: potential applications as a functional food and nutraceutical. Nutr Food Sci Res 3(1):5–16

    Article  CAS  Google Scholar 

  • Kirtikar KR, Basu BD (2002) Indian medicinal plants, vol I. International Book Distributors, Dehradun, India, pp 700–701

    Google Scholar 

  • Kirtikar KR, Basu BD (2003) Indian medicinal plants with illustrations, vol 3, 2nd edn. Oriental Enterprises, Dehradun, India, pp 982–983

    Google Scholar 

  • Ktari N, Trabelsi I, Bardaa S et al (2017) Antioxidant and hemolytic activities, and effects in rat cutaneous wound healing of a novel polysaccharide from fenugreek (Trigonella foenum-graecum) seeds. Int J Biol Macromol 95:625–634

    Article  CAS  PubMed  Google Scholar 

  • Lepage C, Léger DY, Bertrand J et al (2011) Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells. Cancer Lett 30(2):193–202

    Article  CAS  Google Scholar 

  • Li F, Fernandez PP, Rajendran P et al (2010) Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett 292(2):197–207

    Article  CAS  PubMed  Google Scholar 

  • Lim SJ, Jang E, Lee SH et al (2013) Antibiotic resistance in bacteria isolated from freshwater aquacultures and prediction of the persistence and toxicity of antimicrobials in the aquatic environment. J Environ Sci Health 48(6):495–504

    Article  CAS  Google Scholar 

  • Liu MJ, Wang Z, Ju Y et al (2005) Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis. Cancer Chem Pharmacol 55(1):79–90

    Article  CAS  Google Scholar 

  • Luan G, Wang Y, Wang Z et al (2018) Flavonoid glycosides from fenugreek seeds regulate glycolipid metabolism by improving mitochondrial function in 3T3-L1 adipocytes in vitro. J Agric Food Chem 66:3169–3178

    Article  CAS  PubMed  Google Scholar 

  • Lust JB (1986) The herb book. Bantam Books Inc, New York, pp 1–55

    Google Scholar 

  • Madar Z, Shomer IJ (1990) Polysaccharide composition of a gel fraction derived from fenugreek and its effect on starch digestion and bile acid absorption in rats. J Agric Food Chem 38(7):1535–1539

    Article  CAS  Google Scholar 

  • Mahady GB (2009) Medicinal plants for the prevention and treatment of coronary heart disease. Ethnopharmacology II:75–99

    Google Scholar 

  • Malviya KG, Babhulkar MW, Mali P et al (2010) Evaluation of anti-inflammatory potential of Trigonella foenum-graecum (fenugreek) seed extracts by using carrageenan induced rat paw edema. Drug Invent Today 2(2):109–111

    Google Scholar 

  • Mathern JR, Raatz SK, Thomas W et al (2009) Effect of fenugreek fiber on satiety, blood glucose and insulin response and energy intake in obese subjects. Phytother Res 23(11):1543–1548

    Article  CAS  PubMed  Google Scholar 

  • Meghwal M, Goswamy TK (2012) A review on the functional properties, nutritional content, medicinal utilization and potential application of fenugreek. J Food Process Technol 3:9

    Article  Google Scholar 

  • Mendis S, Puska P, Norrving B et al (2011) Global atlas on cardiovascular disease prevention and control. World Health Organization, Geneva, pp 3–18

    Google Scholar 

  • Mercan N, Guvensen A, Celik A et al (2007) Antimicrobial activity and pollen composition of honey samples collected from different provinces in Turkey. Nat Prod Res 21(3):187–195

    Article  CAS  PubMed  Google Scholar 

  • Mesallam DI, Hamid OIA, Ibrahem NE (2018) Ethanolic extract of fenugreek seeds moderates dimethoate-induced pancreatic damage in male rats. Environ Sci Pollut Res 25(4):3894–3904

    Article  CAS  Google Scholar 

  • Mir Z, Mir PS, Acharya SN et al (1998) Comparison of alfalfa and fenugreek (Trigonella foenum-graecum) silages supplemented with barley grain on performance of growing steers. Can J Anim Sci 78(3):343–349

    Article  Google Scholar 

  • Moghadam FH, Vakili-Zarch B, Shafiee M et al (2013) Fenugreek seed extract treats peripheral neuropathy in pyridoxine induced neuropathic mice. Excli J 12:282–290

    PubMed  PubMed Central  Google Scholar 

  • Moradi N, Moradi K (2013) Physiological and pharmaceutical effects of fenugreek (Trigonella foenum-graecum L.) as a multipurpose and valuable medicinal plant. Global J Med Plant Res 1(2):199–206

    Google Scholar 

  • Muhammed DO, Salih NA (2012) Effect of application of Fenugreek (Trigonella foenum-graecum) on skin wound healing in rabbits. AL-Qadisiya J Vet Med Sci 11(2):86–93

    Google Scholar 

  • Muraki E, Hayashi Y, Chiba H et al (2011) Dose-dependent effects, safety and tolerability of fenugreek in diet-induced metabolic disorders in rats. Lipids Health Dis 10(1):240

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Naicker N, Nagiah S, Phulukdaree A et al (2016) Trigonella foenum-graecum seed extract, 4- hydroxyisoleucine, and metformin stimulate proximal insulin signaling and increase expression of glycogenic enzymes and GLUT2 in HepG2 cells. Metab Syndr Relat Disord 14(2):114–120

    Article  CAS  PubMed  Google Scholar 

  • Narasimhamurthy K, Viswanatha S, Ramesh BS (1999) Acute and subchronic toxicity assessment of debitterized fenugreek powder in the mouse and rat. Food Chem Toxicol 37(8):831–838

    Article  PubMed  Google Scholar 

  • Narender T, Puri A, Khaliq T et al (2006) 4-Hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent. Bioorg Med Chem Lett 16(2):293–296

    Article  CAS  PubMed  Google Scholar 

  • Norziah MH, Fezea FA, Bhar R et al (2015) Effect of extraction solvents on antioxidant and antimicrobial properties of fenugreek seeds (Trigonella foenum-graecum L.). Int Food Res J 22(3):1261–1271

    CAS  Google Scholar 

  • Oddepally R, Guruprasad L (2015) Isolation, purification, and characterization of a stable defensin-like antifungal peptide from Trigonella foenum-graecum (fenugreek) seeds. Biochem (Moscow) 80(3):332–342

    Article  CAS  Google Scholar 

  • Olaiya CO, Soetan KO (2014) A review of the health benefits of fenugreek (Trigonella foenum-graecum L.): nutritional, Biochemical and pharmaceutical perspectives. Am J Soc Issues Human:3–12

    Google Scholar 

  • Ou S, Kwok KC, Li Y et al (2001) In-vitro study of possible role of dietary fiber in lowering postprandial serum glucose. J Agr Food Chem 49(2):1026–1029

    Article  CAS  Google Scholar 

  • Ouzir M, El Bairi K, Amzari S (2016) Toxicological properties of fenugreek (Trigonella foenum graecum). Food Chem Toxicol 96:145–154

    Article  CAS  PubMed  Google Scholar 

  • Pandian RS, Anuradha CV, Viswanathan P (2002) Gastroprotective effect of fenugreek seeds (Trigonella foenum graecum) on experimental gastric ulcer in rats. J Ethnopharmacol 81(3):393–397

    Article  PubMed  Google Scholar 

  • Pekiner DB, Evcimen DN, Nebioğlu S (2005) Diabetes-induced decrease in rat brain microsomal Ca2+-ATPase activity. Cell Biochem Funct 23(4):239–243

    Article  CAS  Google Scholar 

  • Petit P, Sauvaire Y, Ponsin G et al (1993) Effects of a fenugreek seed extract on feeding behaviour in the rat: metabolic endocrine correlates. Pharmacol Biochem Behav 45(2):369–374

    Article  CAS  PubMed  Google Scholar 

  • Petit PR, Sauvaire YD, Hillaire-Buys DM et al (1995) Steroid saponins from fenugreek seeds: extraction, purification, and pharmacological investigation on feeding behavior and plasma cholesterol. Steroids 60(10):674–680

    Article  CAS  PubMed  Google Scholar 

  • Preet A, Gupta BL, Siddiqui MR et al (2005) Restoration of ultrastructural and biochemical changes in alloxan-induced diabetic rat sciatic nerve on treatment with Na3VO4 and Trigonella—a promising antidiabetic agent. Mol Cell Biochem 278(1–2):21–31

    Article  CAS  PubMed  Google Scholar 

  • Prema A, Justin Thenmozhi A, Manivasagam T et al (2017) Fenugreek seed powder attenuated aluminum chloride-induced tau pathology, oxidative stress, and inflammation in a rat model of Alzheimer’s disease. J Alzheimer’s Dis 60(s1):S209–S220

    Article  CAS  Google Scholar 

  • Pribac G, Ardelean A, Czapar M et al (2009) Trigonella foenum-graecum and Trigonella policreata seeds extract exert a protective action of alcohol toxicity in BRL3A rat liver cells. Stud Univ Vasile Goldis Arad Stiintele Vietii 19(1):87–93

    Google Scholar 

  • Priya V, Jananie RK, Vijayalakshmi K (2011) GC/MS determination of bioactive components of Trigonella foenum-grecum. J Chem Pharm Res 3(5):35–40

    CAS  Google Scholar 

  • Raju J, Gupta D, Rao AR et al (2001) Trigonella foenum graecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes. Mol Cell Biochem 224(1–2):45–51

    Article  CAS  PubMed  Google Scholar 

  • Raju J, Patlolla JMR, Swamy MV et al (2004) Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells. Cancer Epidemiol Biomarkers Prev 13(8):1392–1398

    CAS  PubMed  Google Scholar 

  • Randhir R, Lin YT, Shetty K (2004) Phenolics, their antioxidant and antimicrobial activity in dark germinated fenugreek sprouts in response to peptide and phytochemical elicitors. Asia Pac J Clin Nutr 13(3):295–307

    CAS  PubMed  Google Scholar 

  • Rao AV (2003) Herbal cure for common diseases. Fusion Books, New Delhi

    Google Scholar 

  • Rashmi Y, Rahul K (2011) Study of phytochemical constituents and pharmacological actions of Trigonella foenum-graecum: a review. Int J Pharm Technol 3:1022–1028

    Google Scholar 

  • Reddy RR, Srinivasan K (2011) Hepatoprotective and antioxidant effect of fenugreek (Trigonella foenum-graecum) seeds in mice under lithogenic condition. J Food Biochem 35(6):1619–1626

    Article  CAS  Google Scholar 

  • Rjat H, Taparia A (1990) Utilization of methi straw by cattle. Indian J Anim Sci 60(11):1380–1381

    Google Scholar 

  • Roberts KT (2011) The potential of fenugreek (Trigonella foenum-graecum) as a functional food and nutraceutical and its effects on glycemia and lipidemia. J Med Food 14(12):1485–1489

    Article  CAS  PubMed  Google Scholar 

  • Roohi Z, Imanpoor MR, Jafari V et al (2017) The use of fenugreek seed meal in fish diets: growth performance, haematological and biochemical parameters, survival and stress resistance of common carp (Cyprinus carpio L.). Aquac Res 48(3):1209–1215

    Article  CAS  Google Scholar 

  • Saber B, Abdeldjelil MC, Benazzouz H et al (2017) Fenugreek (Trigonella foenum-graecum): an alternative antistress in broiler chickens in Algeria. Der Pharm Lett 9(1):64–69

    Google Scholar 

  • Sauvaire Y, Ribes G, Baccou JC et al (1991) Implication of steroid saponins and sapogenins in the hypocholesterolemic effect of fenugreek. Lipids 26(3):191–197

    Article  CAS  PubMed  Google Scholar 

  • Sauvaire Y, Petit P, Broca C et al (1998) 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion. Diabetes 47(2):206–210

    Article  CAS  PubMed  Google Scholar 

  • Saxena R, Rathore SS, Barnwal P et al (2013) Effect of cryogenic grinding on recovery of diosgenin content in fenugreek (Trigonella foenum-graecum L.) genotypes. Int J Seed Spices 3(1):26–30

    Google Scholar 

  • Shabbeer S, Sobolewski M, Anchoori RK et al (2009) Fenugreek: a naturally occurring edible spice as an anticancer agent. Cancer Biol Ther 8(3):272–278

    Article  CAS  PubMed  Google Scholar 

  • Sharma RD, Sarkar A, Hazra DK et al (1996) Hypolipidemic effect of fenugreek seeds: a chronic study in non-insulin dependent diabetic patients. Phytother Res 10(4):332–334

    Article  Google Scholar 

  • Sharma V, Singh P, Rani A (2017) Antimicrobial activity of Trigonella foenum-graecum L. (Fenugreek). Eur J Exp Biol 7(1):4

    Google Scholar 

  • Shishodia S, Aggarwal BB (2006) Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, IκB kinase activation and NF-κB-regulated gene expression. Oncogene 25(10):1463–1473

    Article  CAS  PubMed  Google Scholar 

  • Son IS, Kim JH, Sohn HY et al (2007) Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam (Dioscorea spp.), on high-cholesterol fed rats. Biosci Biotechnol Biochem 71(12):3063–3071

    Article  CAS  PubMed  Google Scholar 

  • Sowmya P, Rajyalakshmi P (1999) Hypocholesterolemic effect of germinated fenugreek seeds in human subjects. Plant Food Hum Nutr 53(4):359–365

    Article  CAS  Google Scholar 

  • Srinivasan K (2006) Fenugreek (Trigonella foenum-graecum): a review of health beneficial physiological effects. Food Rev Int 22(2):203–224

    Article  CAS  Google Scholar 

  • Sumitra M, Manikandan P, Suguna L et al (2000) Study of dermal wound healing activity of Trigonella foenum graceum seeds in rats. J Clin Biochem Nutr 28(2):59–67

    Article  CAS  Google Scholar 

  • Tavakoli MB, Kiani A, Roayaei M (2015) The effects of fenugreek on radiation induced toxicity for human blood T-cells in radiotherapy. J Med Signals Sens 5(3):176

    Article  PubMed  PubMed Central  Google Scholar 

  • Thirunavukkarasu V, Anuradha CV (2007) Gastroprotective effect of fenugreek seeds (Trigonella foenum graecum) on experimental gastric ulcer in rats. J Herbs Spices Med Plants 12(3):13–25

    Article  Google Scholar 

  • Tiran D (2003) The use of fenugreek for breast feeding woman. Comp Ther Nurs Midwifery 9(3):155–156

    Article  Google Scholar 

  • Tripathi S, Maurya AK, Kahrana M et al (2012) Immunomodulatory property of ethanolic extract of Trigonella foenum-graecum leaves on mice. Der Pharm Lett 4(2):708–713

    Google Scholar 

  • Uemura T, Hirai S, Mizoguchi N et al (2010) Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues. Mol Nutr Food Res 54(11):1596–1608

    Article  CAS  PubMed  Google Scholar 

  • Venkata KCN, Bagchi D, Bishayee A (2017) A small plant with big benefits: fenugreek (Trigonella foenum-graecum Linn.) for disease prevention and health promotion. Mol Nutr Food Res 61(6). https://doi.org/10.1002/mnfr.201600950

    Article  CAS  Google Scholar 

  • Wagh P, Rai M, Deshmukh SK et al (2007) Bio-activity of oils of Trigonella foenum-graecum and Pongamia pinnata. Afr J Biotechnol 6(13):1592–1596

    CAS  Google Scholar 

  • Wani SA, Kumar P (2016) Fenugreek: a review on its nutraceutical properties and utilization in various food products. J Saudi Soc Agric Sci 17(2):97–106

    Google Scholar 

  • Yadav S, Sehgal S (1997) Effect of home processing and storage on ascorbic acid and β-carotene content of bathua (Chenopodium album) and fenugreek (Trigonella foenum graecum) leaves. Plant Food Hum Nutr 50(3):239–247

    Article  CAS  Google Scholar 

  • Yadav R, Kaushik R, Gupta D (2011) The health benefits of Trigonella foenum-graecum: a review. Int J Eng Res Appl 1(1):32–35

    Google Scholar 

  • Yesuf K, Mersso B, Bekele T (2017) Effects of different levels of turmeric, fenugreek and black cumin on carcass characteristics of broiler chicken. J Livestock Sci 8:11–17. ISSN: 2277-6214

    Google Scholar 

  • Yoshikawa T, Toyokuni S, Yamamoto Y et al (2000) Free radicals in chemistry biology and medicine. OICA International, London, p 580

    Google Scholar 

  • Zafar MI, Gao F (2016) 4-Hydroxyisoleucine: a potential new treatment for type 2 diabetes mellitus. BioDrugs 30(4):255–262

    Article  CAS  PubMed  Google Scholar 

  • Zhou J, Chan L, Zhou S (2012) Trigonelline: a plant alkaloid with therapeutic potential for diabetes and central nervous system disease. Curr Med Chem 19(21):3523–3531

    Article  CAS  PubMed  Google Scholar 

  • Żuk-Gołaszewska K, Wierzbowska J (2017) Fenugreek: productivity, nutritional values and uses. J Elementol 22(3):1067–1080

    Google Scholar 

Download references

Acknowledgments

The authors are thankful to all the scientists, scholars, and staff of the Division of Pharmacology and Toxicology, Indian Veterinary Research Institute (IVRI), Izzatnagar, Bareilly, India, for their support and cooperation in completion of this book chapter.

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kumar, D., Wangkheirakpam, R.S., Rahal, A., Malik, J.K. (2019). Fenugreek in Health and Disease. In: Gupta, R., Srivastava, A., Lall, R. (eds) Nutraceuticals in Veterinary Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-04624-8_2

Download citation

Publish with us

Policies and ethics