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Polyphenols and Flavonoids

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Book cover Nutraceuticals in Veterinary Medicine

Abstract

Majority of the plants used in traditional system of medicine are rich in polyphenols and flavonoids which not only regulate the growth of plants but also are rich source of phytochemicals employed in human and animal health. Polyphenols and flavonoids have been advocated as nutraceuticals in human medicine to treat certain modern lifestyle diseases including cancer. These phytochemicals seem to possess great potential for their use in animal health and production system and to replace certain synthetic chemicals which are deleterious on account of their residual effects on human and animal health. Some of the common polyphenols and flavonoids possessing desirable pharmacological activities and the potential for use in livestock and poultry sectors are kaempferol, quercetin, genistein, rutin, catechin, etc. Similarly, some of the plants rich in polyphenols and flavonoids can be used as green fodder and as feed supplements to formulate certain functional foods for augmenting productivity of animals and poultry.

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References

  • Adlercreutz H, Mazur W (1997) Phytoestrogens and western diseases. Ann Med 29:95–120

    CAS  PubMed  Google Scholar 

  • Alam M, Rakib A, Abdullah-Al-Hasan M et al (2015) Effects of neem leave powder as a growth promoter in broilers. Int J Nat Soc Sci 2:22–26

    Google Scholar 

  • Amic D, Davidovic A, Beslo D et al (2007) SAR and QSAR of the antioxidant activity of flavonoids. Curr Med Chem 14:827–845

    CAS  PubMed  Google Scholar 

  • Atkins C, Bonagura J, Ettinger S et al (2009) Guidelines for the diagnosis and treatment of canine chronic valvular heart disease. J Vet Intern Med 23(6):1142–1150

    CAS  PubMed  Google Scholar 

  • Augusti KT, Prabha SP, Smitha KB et al (2005) Nutraceutical effects of garlic oil, its nonpolar fraction and a Ficus flavonoid as compared to vitamin E in CCl4-induced liver damage in rats. Indian J Exp Biol 43(05):437–444

    CAS  PubMed  Google Scholar 

  • Aziz NH, Farag SE, Mousa LA et al (1998) Comparative antibacterial and antifungal effects of some phenolic compounds. Microbios 93(374):43–54

    CAS  PubMed  Google Scholar 

  • Barden CA, Chandler HL, Lu P et al (2008) Effect of grape polyphenols on oxidative stress in canine lens epithelial cells. Am J Vet Res 69(1):94–100

    CAS  PubMed  Google Scholar 

  • Barotto NN, Lopez CB, Eynard AR et al (1998) Quercetin enhances pretumorous lesions in NMU model of rat pancreatic carcinogenesis. Cancer Lett 129:1–6

    CAS  PubMed  Google Scholar 

  • Belay A, Gholap AV (2009) Characterization and determination of chlorogenic acids (CGA) in coffee beans by UV-VIS spectroscopy. Afr J Pure Appl Chem 3(11):234–240

    CAS  Google Scholar 

  • Bharshiv CK, Garg SK, Bhatia AK (2016) Immunomodulatory activity of aqueous extract of Nyctanthes arbor-tristis flowers with particular reference to splenocytes proliferation and cytokines induction. Indian J Pharm 48(4):412–417

    CAS  Google Scholar 

  • Bhat K, Pezzuto JM (2002) Cancer chemopreventive activity of resveratrol. Ann N Y Acad Sci 957:210–229

    CAS  PubMed  Google Scholar 

  • Bhushan B, Garg SK, Kumar J, Shukla PK (2008) Effect of polyherbal feed supplement on production performance and nutrient utilization in broiler chicks. Indian J Poult Sci 43(1):67–70

    Google Scholar 

  • Bohn T (2014) Dietary factors affecting polyphenol bioavailability. Nutr Rev 72(7):429–452

    PubMed  Google Scholar 

  • Bors W, Heller W, Michel C et al (1990) In: Packer L, Glazer AN (eds) Methods in enzymology, vol 186. Academic Press, San Diego, CA, pp 343–355

    Google Scholar 

  • Breinholt V, Hossaini A, Svendsen GW et al (2000) Estrogenic activity of flavonoids in mice. The importance of estrogen receptor distribution, metabolism and bioavailability. Food Chem Toxicol 38(7):555–564

    CAS  PubMed  Google Scholar 

  • Brglez M (2016) Polyphenols: extraction methods, antioxidative action, bioavailability and anticarcinogenic effects. Molecules 21(7):901

    Google Scholar 

  • Bull E (2000) What is nutraceutical? Pharm J 265:57–58

    Google Scholar 

  • Burnett BP, Stenstrom KK, Baarsch MJ et al (2009) A flavonoid mixture, dual inhibitor of cyclooxygenase and 5-lipoxygenase enzymes, shows superiority to glucosamine/chondroitin for pain management in moderate osteoarthritic dogs. Int J Appl Res Vet Med 7(1):1–10

    CAS  Google Scholar 

  • Caturla N, Vera-Samper E, Villalaín J et al (2003) The relationship between the antioxidant and the antibacterial properties of galloylated catechins and the structure of phospholipid model membranes. Free Radic Biol Med 34(6):648–662

    CAS  PubMed  Google Scholar 

  • Cemeli E, Schmid TE, Anderson D (2004) Modulation by flavonoids of DNA damage induced by estrogen-like compounds. Environ Mol Mutagen 44:420–426

    CAS  PubMed  Google Scholar 

  • Chen ZY, Chan PT, Ho KY et al (1996) Antioxidant activity of natural flavonoids is governed by number and location of their aromatic hydroxyl groups. Chem Phys Lipids 79:157–163

    CAS  PubMed  Google Scholar 

  • Cheynier V (2005) Polyphenols in foods are more complex than often thought. Am J Clin Nutr 81:223S–229S

    CAS  PubMed  Google Scholar 

  • Choi YT, Jung CH, Lee SR et al (2001) The green tea polyphenol(−)-epigallocatechin gallate attenuates b-amyloid-induced neurotoxicity in cultured hippocampal neurons. Life Sci 70:603–614

    CAS  PubMed  Google Scholar 

  • Choi HJ, Kim JH, Lee CH et al (2009) Antiviral activity of quercetin 7-rhamnoside against porcine epidemic. Antivir Res 81(1):77–80

    CAS  PubMed  Google Scholar 

  • Clifford MN (1999) Chlorogenic acids and other cinnamates–nature, occurrence and dietary burden. J Sci Food Agric 79:362–372

    CAS  Google Scholar 

  • Clifford MN, Scalbert A (2000) Ellagitannins–nature, occurrence and dietary burden. J Sci Food Agric 80(7):1118–1125

    CAS  Google Scholar 

  • Corder R, Douthwaite JA, Lees DM et al (2001) Health: endothelin-1 synthesis reduced by red wine. Nature 414(6866):863

    CAS  PubMed  Google Scholar 

  • Corona G, Spencer JP, Dessi MA (2009) Extra virgin olive oil phenolics: absorption, metabolism, and biological activities in the GI tract. Toxicol Ind Health 25:285–293

    CAS  PubMed  Google Scholar 

  • Cushnie TT, Lamb AJ (2005) Antimicrobial activity of flavonoids. Int J Antimicrob Agents 26(5):343–356

    CAS  PubMed  PubMed Central  Google Scholar 

  • Czapek F (1925) Biochemie der Pflanzen, vol 2. G. Fischer, Switzerland

    Google Scholar 

  • Day AJ, Canada FJ, Diaz JC et al (2000) Dietary flavonoid and isoflavones glycosides are hydrolysed by the lactase site of lactase phloridzin hydrolase. FEBS Lett 468:166–170

    CAS  PubMed  Google Scholar 

  • Demrow HS, Slane PR, Folts JD (1995) Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation 91:1182–1188

    CAS  PubMed  Google Scholar 

  • Divya, Mandal AB, Biswas A et al (2014) Effect of dietary Moringa oleifera leaves powder on growth performance, blood chemistry, meat quality and gut microflora of broiler chicks. Anim Nutr Feed Technol 14:349–357

    Google Scholar 

  • Domanski M, Mitchell G, Pfeffer M et al (2002) Pulse pressure and cardiovascular disease-related mortality: follow-up study of the multiple risk factor intervention trial (MRFIT). JAMA 287:2677–2683

    PubMed  Google Scholar 

  • Donovan JL, Bell JR, Kasim KS et al (1999) Catechin is present as metabolites in human plasma after consumption of red wine. J Nutr 129:1662–1668

    CAS  PubMed  Google Scholar 

  • Donovan JL, Manach C, Faulks RM et al (2006) Absorption and metabolism of dietary secondary metabolites. In: Crozier A, Clifford MN, Ashihara H (eds) Plant secondary metabolites: occurrence, structure and role in the human diet. Blackwell Publishing, Oxford, NY, pp 303–351

    Google Scholar 

  • Erlund I, Silaste ML, Alfthan G et al (2002) Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables. Eur J Clin Nutr 56:891–898

    CAS  PubMed  Google Scholar 

  • Evan SK, Braunwald E, Wood HF (2007) A study of C-reactive protein in the serum of patients with congestive heart failure. Am Heart J 51:533–541

    Google Scholar 

  • Faria A, Fernandes I, Norberto S et al (2014) Interplay between anthocyanins and gut microbiota. J Agric Food Chem 62:6898–6902

    CAS  PubMed  Google Scholar 

  • Farzaei MH, Bahramsoltani R, Abdollahi M et al (2016) The role of visceral hypersensitivity in irritable bowel syndrome: pharmacological targets and novel treatments. J Neurogastroenterol Motil 22:558–574

    PubMed  PubMed Central  Google Scholar 

  • Field J, Rekers PE (1949) Studies of the effects of flavonoids on roentgen irradiation disease. comparison of the protective influence of some flavonoids and vitamin c in dogs. J Clin Invest 28(4):746–751

    PubMed  PubMed Central  Google Scholar 

  • Forester SC, Waterhouse AL (2008) Identification of Cabernet Sauvignon anthocyanin gut microflora metabolites. J Agric Food Chem 56(19):9299–9304

    CAS  PubMed  Google Scholar 

  • Formica JV, Regelson W (1995) Review of biology of quercetin and related bioflavonoids. Food Chem Toxicol 33:1061–1080

    CAS  PubMed  Google Scholar 

  • Fotsis T, Pepper MS, Aktas E et al (1997) Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Res 57:2916–2921

    CAS  PubMed  Google Scholar 

  • Fremont L, Belguendouz L, Delpal S (1999) Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci 64:2511–2521

    CAS  PubMed  Google Scholar 

  • Ganesan K, Xu B (2017) A critical review on polyphenols and health benefits of black soybeans. Nutrients 9:455. https://doi.org/10.3390/nu9050455

    Article  CAS  PubMed Central  Google Scholar 

  • Garg SK (2016) Green coffee bean. In: Gupta RC (ed) Nutraceuticals: efficacy, safety and toxicity, 1st edn. Academic Press/Elsevier, San Diego, CA, pp 653–667

    Google Scholar 

  • Gee JM, DuPont SM, Day AJ et al (2000) Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway. J Nutr 130:2765–2771

    CAS  PubMed  Google Scholar 

  • Geetha S, Singh V, Havazhagan G et al (2002) Antioxidant and immunomodulatory properties of Sea buckthorn—an in vitro study. J Ethnopharmacol 79:373–378

    CAS  PubMed  Google Scholar 

  • Goliomytis M, Tsoureki D, Simitzis PE et al (2014) The effects of quercetin dietary supplementation on broiler growth performance, meat quality, and oxidative stability. Poult Sci 93:1957–1962

    CAS  PubMed  Google Scholar 

  • Graefe EU, Wittig J, Mueller S et al (2001) Pharmacokinetics and bioavailability of quercetin glycosides in humans. J Clin Pharmacol 41:492–499

    CAS  PubMed  Google Scholar 

  • Gravina HD, Tafuri NF, Silva Júnior A et al (2011) In vitro assessment of the antiviral potential of trans cinnamic acid, quercetin and morin against equid herpesvirus 1. Res Vet Sci 91(3):158–162

    Google Scholar 

  • Greiner LL, Stahl TS, Stabel TJ (2001) The effect of dietary soy genistein on pig growth and viral replication during a viral challenge. J Anim Sci 79(5):1272–1279

    CAS  PubMed  Google Scholar 

  • Guo Z, Yang X, Sun F et al (2009) A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion–resistant growth. Cancer Res 69(6):2305–2313

    CAS  PubMed  PubMed Central  Google Scholar 

  • Guo H, Xia M, Zou T et al (2012) Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1. J Nutr Biochem 23:349–360

    CAS  PubMed  Google Scholar 

  • Haqqi TM, Anthony DD, Gupta S et al (1999) Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proc Natl Acad Sci USA 96(8):4524–4529

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hatcher DW, Kruger JE (1997) Simple phenolic acids in flours prepared from Canadian wheat: relationship to ash content, color, and polyphenol oxidase activity. Cereal Chem 74:337–343

    CAS  Google Scholar 

  • Heaney R (2002) Effects of caffeine on bone and calcium economy. Food Chem Toxicol 40:1263–1270

    CAS  PubMed  Google Scholar 

  • Hider RC, Liu ZD, Khodr HH (2001) Metal chelation of polyphenols. Methods Enzymol 335:190–203

    CAS  PubMed  Google Scholar 

  • Hollman PC, Katan MB (1997) Absorption, metabolism and health effects of dietary flavonoids in man. Biomed Pharmacother 51:305–310

    CAS  PubMed  Google Scholar 

  • Hollman PCH, van het Hof KH, Tijburg LBM et al (2001) Addition of milk does not affect the absorption of flavonols from tea in man. Free Radic Res 34:297–300

    CAS  PubMed  Google Scholar 

  • Huang RY, Yu YL, Cheng WC et al (2010) Immunosuppressive effect of quercetin on dendritic cell activation and function. J Immunol 184(12):6815–6821

    CAS  PubMed  Google Scholar 

  • Ichimura T, Otake T, Mori H et al (1999) HIV-1 protease inhibition and anti-HIV effect of natural and synthetic water-soluble lignin-like substances. Biosci Biotechnol Biochem 63(12):2202–2204

    CAS  PubMed  Google Scholar 

  • Iqbal Z, Kamran Z, Sultan JI et al (2015) Replacement effect of vitamin E with grape polyphenols on antioxidant status, immune, and organs histopathological responses in broilers from 1- to 35-d age. J Appl Poult Res 24(2):127–134

    CAS  Google Scholar 

  • Jaganath IB, Mullen W, Edwards CA et al (2006) The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man. Free Radic Res 40:1035–1046

    CAS  PubMed  Google Scholar 

  • Jayanthi M, Garg SK, Yadav P et al (2015) Some newer marker phytoconstituents in methanolic extract of Moringa oleifera leaves and evaluation of its immunomodulatory and splenocytes proliferation potential in rats. Indian J Pharm 47(5):518–523

    CAS  Google Scholar 

  • Jeon SY, Bae K, Seong YH et al (2003) Green tea catechins as a BACE1 (beta-secretase) inhibitor. Bioorg Med Chem Lett 13(22):3905–3908

    CAS  PubMed  Google Scholar 

  • Ju YH, Allred CD, Allred KF et al (2001) Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice. J Nutr 131(11):2957–2962

    CAS  PubMed  Google Scholar 

  • Jung CH, Lee JY, Cho CH et al (2007) Anti-asthmatic action of quercetin and rutin in conscious guinea-pigs challenged with aerosolized ovalbumin. Arch Pharm Res 30(12):1599–1607

    CAS  PubMed  Google Scholar 

  • Kampa M, Vassilia-Ismini A, George N et al (2004) Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action. Breast Cancer Res 6:63–74

    Google Scholar 

  • Kauss T, Moynet D, Rambert J et al (2008) Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis. Arthritis Res Ther 10(1):R19

    PubMed  PubMed Central  Google Scholar 

  • Kim HP, Mani I, Iversen L et al (1998) Effects of naturally-occurring flavonoids and bioflavonoid on epidermal cyclooxygenase and lipoxygenase from guinea-pigs. Prostaglandins Leukot Essent Fatty Acids 58(1):17–24

    CAS  PubMed  Google Scholar 

  • Kim Y, Narayanan S, Chang K (2010) Inhibition of influenza virus replication by plant-derived isoquercetin. Antivir Res 88:227–235

    CAS  PubMed  Google Scholar 

  • Korver D (2012) Implications of changing immune function through nutrition in poultry. Anim Feed Sci Technol 173:54–64

    CAS  Google Scholar 

  • Kossel A (1891) Uber die Chemische Zusammensetzung der Zelle. Arch Physiol 1891:181–186

    Google Scholar 

  • Kumamoto M, Sonda T, Nagayama K et al (2001) Effects of pH and metal ions on antioxidative activities of catechins. Biosci Biotechnol Biochem 65(1):126–132

    CAS  PubMed  Google Scholar 

  • Lala G, Malik M, Zhao C et al (2006) Anthocyanin-rich extracts inhibits multiple biomarkers of colon cancer in rats. Nutr Cancer 54:84–93

    CAS  PubMed  Google Scholar 

  • Larrosa M, Garcia-Conesa MT, Espín JC et al (2010) Ellagitannins, ellagic acid and vascular health. Mol Asp Med 31(6):513–539

    CAS  Google Scholar 

  • Lee J, Koo N, Min DB (2004) Reactive oxygen species, aging, and antioxidative nutraceuticals. Compr Rev Food Sci Technol 3:21–33

    CAS  Google Scholar 

  • Lempereur I, Rouau X, Abecassis J (1997) Genetic and agronomic variation in arabinoxylan and ferulic acid contents of durum wheat (Triticum durum L.) grain and its milling fractions. J Cereal Sci 25:103–110

    CAS  Google Scholar 

  • Levites Y, Amit T, Mandel S et al (2003) Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (−)-epigallocatechin-3-gallate. FASEB J 17:952–954

    CAS  PubMed  Google Scholar 

  • Liu H, Qiu N, Ding H et al (2008) Polyphenols contents and antioxidant capacity of 68 Chinese herbals suitable for medical or food uses. Food Res Int 41(4):363–370

    CAS  Google Scholar 

  • Lloyd-Jones DM, Larson MG, Leip EP et al (2002) Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation 106:3068–3072

    PubMed  Google Scholar 

  • Lou Z, Wang H, Zhu S et al (2011) Antibacterial activity and mechanism of action of chlorogenic acid. J Food Sci 76(6):M398–M403

    CAS  PubMed  Google Scholar 

  • Low S, Peak RM, Smithson CW et al (2014) Evaluation of a topical gel containing a novel combination of essential oils and antioxidants for reducing oral malodor in dogs. Am J Vet Res 75(7):653–657

    PubMed  Google Scholar 

  • Maddi VS, Aragade PD, Digge VG et al (2007) Importance of nutraceuticals in health management. Pharmacol Rev 1:377–379

    Google Scholar 

  • Maleser D, Kuntic V (2007) Investigation of metal-flavonoid chelates and the determination of flavonoids via metal-flavonoid complexing reactions. J Serb Chem Soc 72:921–939

    Google Scholar 

  • Manach C, Scalbert A, Morand C et al (2004) Polyphenols: food sources and bioavailability. Am J Clin Nutr 79:727–747

    CAS  PubMed  Google Scholar 

  • Manach C, Williamson G, Morand C et al (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81:230S–242S

    CAS  PubMed  Google Scholar 

  • Mandel S, Weinreb O, Amit T et al (2004) Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (−)-epigallocatechin-3-gallate: implications for neurodegenerative diseases. J Neurochem 88:1555–1569

    CAS  PubMed  Google Scholar 

  • Mantena SK, Baliga MS, Katiyar SK (2006) Grape seed proanthocyanidins induce apoptosis and inhibit metastasis of highly metastatic breast carcinoma cells. Carcinogenesis 27:1682–1691

    CAS  PubMed  Google Scholar 

  • Marin L, Miguelez EM, Villar CJ et al (2015) Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties. Biomed Res Int 2015:905215

    PubMed  PubMed Central  Google Scholar 

  • Marks SC, Mullen W, Borges G et al (2009) Absorption, metabolism, and excretion of cider dihydrochalcones in healthy humans and subjects with an ileostomy. J Agric Food Chem 57:2009–2015

    CAS  PubMed  Google Scholar 

  • Matthies A, Clavel T, Gütschow M et al (2008) Conversion of daidzein and genistein by an anaerobic bacterium newly isolated from the mouse intestine. Appl Envrion Microbiol 74:4847–4852

    CAS  Google Scholar 

  • McNiven MA, Richardson GF (2006) Effect of quercetin on capacitation status and lipid peroxidation of stallion spermatozoa. Cell Preserv Technol 4:3. https://doi.org/10.1089/cpt.2006.4.169

    Article  Google Scholar 

  • Montero R (2016) Alterations in primary and secondary metabolism in Vitis vinifera ‘Malvasía de Banyalbufar’ upon infection with Grapevine leafroll-associated virus 3. Physiol Plant 157(4):442–452

    CAS  PubMed  Google Scholar 

  • Moon JH, Nakata R, Oshima S et al (2000) Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women. Am J Phys 279:R461–R467

    CAS  Google Scholar 

  • Owen RW, Giacosa A, Hull WE et al (2000) The antioxidant/anticancer potential of phenolic compounds isolated from olive oil. Eur J Cancer 36:1235–1247

    CAS  PubMed  Google Scholar 

  • Panche AN, Diwan AD, Chandra SR (2016) Flavonoids: an overview. J Nutr Sci 5(47):1–15

    Google Scholar 

  • Pandey M, Verma RK, Saraf SA (2010) Nutraceuticals: new era of medicine and health. Asian J Pharm Clin Res 3:11–15

    Google Scholar 

  • Pathak AK, Nainwal N, Goyal BM et al (2010) Pharmacological activity of Trachyspermum ammi: a review. J Pharm Res 3(4):895–899

    CAS  Google Scholar 

  • Pinto P, Santos CN (2017) Worldwide polyphenol intake: assessment methods and identified gaps. Eur J Nutr 56:1393–1408

    CAS  PubMed  Google Scholar 

  • Proestos C, Bakogiannis A, Psarianos C et al (2005) High performance liquid chromatography analysis of phenolic substances in Greek wines. Food Control 16:319–323

    CAS  Google Scholar 

  • Rees CR, Costin JM, Fink RC et al (2008) In vitro inhibition of dengue virus entry by p-sulfoxy-cinnamic acid and structurally related combinatorial chemistries. Antivir Res 80:135–142

    CAS  PubMed  Google Scholar 

  • Resuleo G (2016) Resveratrol: multiple activities on the biological functionality of the cell. In: Gupta RC (ed) Nutraceuticals: efficacy, safety and toxicity, 1st edn. Academic Press/Elsevier, San Diego, CA, pp 453–464

    Google Scholar 

  • Ross R (1999) Atherosclerosis – an inflammatory disease. N Engl J Med 340:115–126

    CAS  PubMed  Google Scholar 

  • Rupasinghe HP, Ronalds CM, Rathgeber B et al (2010) Absorption and tissue distribution of dietary quercetin and quercetin glycosides of apple skin in broiler chickens. J Sci Food Agric 90:1172–1178

    CAS  PubMed  Google Scholar 

  • Saha RK, Takahashi T, Suzuki T (2009) Glucosyl hesperidin prevents influenza a virus replication in vitro by inhibition of viral sialidase. Biol Pharm Bull 32(7):1188–1192

    CAS  PubMed  Google Scholar 

  • Saura-Calixto F, Serrano J, Goñi I (2007) Intake and bioaccessibility of total polyphenols in a whole diet. Food Chem 101:492–501

    CAS  Google Scholar 

  • Schnitzler P, Nolkemper S, Stintzing FC et al (2008) Comparative in vitro study on the anti-herpetic effect of phytochemically characterized aqueous and ethanolic extracts of Salvia officinalis grown at two different locations. Phytomedicine 15(1–2):62–70

    CAS  PubMed  Google Scholar 

  • Selma MV, Espin JC, Tomas-Barberan FA (2009) Interaction between phenolics and gut microbiota: role in human health. J Agric Food Chem 57:6485–6501

    CAS  PubMed  Google Scholar 

  • Serafini M, Ghiselli A, Ferro-Luzzi A (1996) In vivo antioxidant effect of green and black tea in man. Eur J Clin Nutr 50:28–32

    CAS  PubMed  Google Scholar 

  • Shahidi F, Naczk M (1995) Food phenolics, sources, chemistry, effects, applications. Technomic Publishing, Lancaster, PA

    Google Scholar 

  • Siard MH, McMurry KE, Adams AA (2016) Effects of polyphenols including curcuminoids, resveratrol, quercetin, pterostilbene, and hydroxypterostilbene on lymphocyte pro-inflammatory cytokine production of senior horses in vitro. Vet Immunol Immunopathol 173:50–59

    CAS  PubMed  Google Scholar 

  • Sichel G, Corsaro C, Scalia M et al (1991) In vitro scavenger activity of some flavonoids and melanins against O2-(.). Free Radic Biol Med 11:1–8

    CAS  PubMed  Google Scholar 

  • Silva G, Fachin AL, Beleboni RO et al (2013) In vitro action of flavonoids in the canine malignant histiocytic cell line DH82. Molecules 18(12):15448–15463

    CAS  PubMed  PubMed Central  Google Scholar 

  • Singh A, Bora TC, Singh NR (2012) Preliminary photochemical analysis and antimicrobial potential of fermented Bambusa balcooa shoots. Bioscan 7(3):391–394

    CAS  Google Scholar 

  • Stefani ED, Boffetta P, Deneo-Pellegrini H et al (1999) Dietary antioxidants and lung cancer risk: a case-control study in Uruguay. Nutr Cancer 34:100–110

    CAS  PubMed  Google Scholar 

  • Subiza J, Subiza JL, Hinojosa M et al (1989) Anaphylactic reaction after the ingestion of chamomile tea: a study of cross-reactivity with other composite pollens. J Allergy Clin Immunol 84:353–358

    CAS  PubMed  Google Scholar 

  • Sultana B, Anwar F, Przybylski R (2007) Antioxidant activity of phenolic components present in barks of Azadirachta indica, Terminalia arjuna, Acacia nilotica, and Eugenia jambolana Lam. trees. Food Chem 104(3):1106–1114

    CAS  Google Scholar 

  • Swain B, Naik PK, Chakurkar EB et al (2017) Effect of Supplementation of Moringa oleifera leaf meal (MOLM) on the performance of Vanaraja laying hens. Indian J Anim Sci 87(3):353–355

    Google Scholar 

  • Tajik N, Tajik M, Mack I et al (2017) The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature. Eur J Nutr 56:2215–2244

    CAS  PubMed  Google Scholar 

  • Tao J, Hu Q, Yang J et al (2007) In vitro anti-HIV and -HSV activity and safety of sodium rutin sulfate as a microbicide candidate. Antivir Res 75:227–233

    CAS  PubMed  Google Scholar 

  • Thapa M, Kim Y, Desper J et al (2011) Synthesis and antiviral activity of substituted quercetins. Bioorg Med Chem Lett 22(1):353–356

    PubMed  PubMed Central  Google Scholar 

  • Tijburg LBM, Mattern T, Folts JD et al (1997) Tea flavonoids and cardiovascular diseases: a review. Crit Rev Food Sci Nutr 37:771–785

    CAS  PubMed  Google Scholar 

  • Tomas-Barberan FA, Clifford MN (2000) Flavanones, chalcones and dihydrochalcones—nature, occurrence and dietary burden. J Sci Food Agric 80:1073–1080

    CAS  Google Scholar 

  • Toshiya A, Manabu O, Hideyuki H et al (1999) Hypokalemia with syncope caused by habitual drinking of oolong tea. Intern Med 38:252–256

    Google Scholar 

  • Towler MC, Hardie DG (2007) AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res 100(3):328–341

    CAS  PubMed  Google Scholar 

  • Valdes KI, Salem AZM, Lopez S et al (2015) Influence of exogenous enzymes in presence of Salix babylonica extract on digestibility, microbial protein synthesis and performance of lambs fed maize silage. J Agric Sci 153:732–742

    CAS  Google Scholar 

  • Vita JA (2005) Polyphenols and cardiovascular disease: effects on endothelial and platelet function. Am J Clin Nutr 81:292–297

    Google Scholar 

  • Vogelstein B, Kinzler KW (2004) Cancer genes and the pathways they control. Nat Med 10:789–799

    CAS  PubMed  Google Scholar 

  • Wang LQ (2002) Mammalian phytoestrogens: enterodiol and enterolactone. J Chromatogr B Analyt Technol Biomed Life Sci 777(1–2):289–309

    CAS  PubMed  Google Scholar 

  • Wang J, Zhang Q, Jin S et al (2008) Genistein modulate immune responses in collagen-induced rheumatoid arthritis model. Maturitas 59:405–412

    CAS  PubMed  Google Scholar 

  • Wein S, Wolffram S (2014) Concomitant intake of quercetin with a grain-based diet acutely lowers postprandial plasma glucose and lipid concentrations in pigs. Biomed Res Int 2014:748742

    PubMed  PubMed Central  Google Scholar 

  • Whelton PK, He J, Appel LJ et al (2002) Primary prevention of hypertension: clinical and public health advisory from The National High Blood Pressure Education Program. JAMA 288:1882–1888

    PubMed  Google Scholar 

  • Wildman REC (ed) (2001) Handbook of nutraceuticals and functional foods. CRC Press, Boca Raton, pp 13–30

    Google Scholar 

  • Wu T, Zang X, He M et al (2013) Structure-activity relationship of flavonoids on their anti-Escherichia coli activity and inhibition of DNA gyrase. J Agric Food Chem 61(34):8185–8190

    CAS  PubMed  Google Scholar 

  • Yang J, Guo J, Yuan J (2008) In vitro antioxidant properties of rutin. LWT-Food Sci Technol 41(6):1060–1066

    CAS  Google Scholar 

  • Yang C, Yifan L, Dan L et al (2015) Bamboo leaf flavones and tea polyphenols show a lipid-lowering effect in a rat model of hyperlipidemia. Drug Res (Stuttg) 65(12):668–671

    CAS  Google Scholar 

  • Zandi K, Teoh B, Sam S et al (2011) In vitro antiviral activity of fisetin, rutin and naringenin against dengue virus type-2. J Med Plant Res 4(23):5534–5539

    Google Scholar 

  • Zern TL, West KL, Fernandez ML (2003) Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs. J Nutr 133(7):2268–2272

    CAS  PubMed  Google Scholar 

  • Zhang G, Flach CR, Mendelsohn R (2007) Tracking the dephosphorylation of resveratrol triphosphate in skin by confocal Raman microscopy. J Control Release 123(2):141–147

    CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, U.P. Pandit Deen Dayal Upadhyaya Veterinary University (DUVASU), Mathura, Uttar Pradesh, India

    Satish Kumar Garg, Amit Shukla & Soumen Choudhury

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  1. Satish Kumar Garg
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  2. Amit Shukla
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  3. Soumen Choudhury
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Editors and Affiliations

  1. Department of Toxicology, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA

    Ramesh C. Gupta

  2. Vets Plus Inc., University of Wisconsin–Stout, Menonomie, WI, USA

    Ajay Srivastava

  3. Vets Plus Inc., Menomonie, WI, USA

    Rajiv Lall

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Garg, S.K., Shukla, A., Choudhury, S. (2019). Polyphenols and Flavonoids. In: Gupta, R., Srivastava, A., Lall, R. (eds) Nutraceuticals in Veterinary Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-04624-8_13

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